This chapter reveals the overview of mobile health systems; the adoption of mobile health systems; mobile health systems and patient monitoring; the overview of mobile health technology; the advanced issues of Electronic Health Record (EHR); and the challenges of EHR in global health care. Mobile health helps deliver the health care services with quality care, improved workflow, and increased patient interaction while minimizing complexity and cost to achieve the desired goals in health care settings. EHR systems are the real-time and patient-centered records that make information available instantly and securely to authorized users. The chapter argues that applying mobile health systems and EHR has the potential to improve health care efficiency and gain sustainable competitive advantage in global health care.