This article features a review of communication scholarship about sex from the past two decades (2000-2020). A typographic analysis of relevant research reveals 11 primary topic areas related to how interpersonal sexual communication is commonly researched in communication studies. Six of these topic areas are relationship-oriented in nature: flirting and initiation; pleasure and desire; sexual expectations; relational and sexual satisfaction; communication after sex; and negative aspects of sex and sexuality. Three of the topics are health-oriented in nature: sex education, especially in consideration of how parent-child talk happens in families; negotiation of safe sex practices; and sexual dysfunction. Finally, two of the topics are cultural in nature: social factors and influences; and media influences and representations. Scholarship is also reviewed in terms of theoretical commitments, with most research following sociopsychological or critical traditions but with a noteworthy number also embracing sociocultural or biological paradigms. Based on these observations, five directions are offered for future research: supporting programs of interpersonal sex research; advancing and/or creating methods related to communication sex research; eliminating heteronormativity; considering the practical aspects of sex research; and, perhaps most importantly, theorizing sex as communication.