Teleradiotherapy of joints in rheumatoid arthritis: lack of efficacy

Graninger, Marianne; Handl-Zeller, L; Hohenberg, G; Staudenherz, Anton; Kainberger, Franz; Graninger, Winfried

doi:10.1136/ard.2004.021766

Cited by 4 publications

(2 citation statements)

References 8 publications

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“…Literature [39] indicates a lack of efficacy in the use of ionizing radiation for treating rheumatoid arthritis. The authors conducted a randomized, controlled, double blind study in which one of the patients' joints was treated with X-rays from a LINAC (20 Gy in 10 fractions over 2 weeks) and another joint was treated by sham radiation.…”

Section: Indication/results and Outcomesmentioning

confidence: 99%

The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit

et al. 2020

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Disabilities as a result of musculoskeletal disorders increased by 45% from 1990 to 2010. Furthermore, OA is listed by the World Health Organization as the fastest increasing major health condition and ranked as the 2nd leading cause of disability [3]. OA is the underlying cause for more than 90% of the increasing number of total hip or knee joint replacement operations worldwide [4]. Studies from Africa show the prevalence of OA in South Africa is over 29.5% while that of Nigeria is 0.4% [5]. The Community Oriented Program for Control of Rheumatic Diseases (COPCORD) studies in Asia show the prevalence of OA is as high as 34% among people in the 60-64 years age bracket [6]. In the United States, the prevalence of OA increased from 6.6% in 1999 to 14.3% in 2014 [7]. However, in the same time-period, in the United States, the prevalence of rheumatoid arthritis (RA) reduced from 5.9% to 3.8% [7]. Rheumatoid arthritis is the 2nd highest attributable disease to global disability [8]. It has a twofold morbidity among women compared to men [9]. And it has been estimated that China had

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Section: Indication/results and Outcomesmentioning

confidence: 99%

The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit

et al. 2020

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“…11 This therapy, although effective, is not normally used because of the potential late effects resulting from the radiation. It is hypothesized that more standard radiotherapy, in the form of external irradiation up to 20 Gy to an affected joint, could also be used as a treatment; however, there have been varying degrees of efficacy noted (113). In what is perhaps the closest clinical situation to a radiation emergency scenario, a retrospective analysis was conducted on a database of women with RA who were undergoing radiotherapy for breast cancer (114).…”

Section: Individuals With Altered Immune Responsesmentioning

confidence: 99%

Considerations of Medical Preparedness to Assess and Treat Various Populations During a Radiation Public Health Emergency

et al. 2023

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During a radiological or nuclear public health emergency, given the heterogeneity of civilian populations, it is incumbent on medical response planners to understand and prepare for a potentially high degree of inter-individual variability in the biological effects of radiation exposure. A part of advanced planning should include a comprehensive approach, in which the range of possible human responses in relation to the type of radiation expected from an incident has been thoughtfully considered. Although there are several reports addressing the radiation response for special populations (as compared to the standard 18–45-year-old male), the current review surveys published literature to assess the level of consideration given to differences in acute radiation responses in certain sub-groups. The authors attempt to bring clarity to the complex nature of human biology in the context of radiation to facilitate a path forward for radiation medical countermeasure (MCM) development that may be appropriate and effective in special populations. Consequently, the focus is on the medical (as opposed to logistical) aspects of preparedness and response. Populations identified for consideration include obstetric, pediatric, geriatric, males, females, individuals of different race/ethnicity, and people with comorbidities. Relevant animal models, biomarkers of radiation injury, and MCMs are highlighted, in addition to underscoring gaps in knowledge and the need for consistent and early inclusion of these populations in research. The inclusion of special populations in preclinical and clinical studies is essential to address shortcomings and is an important consideration for radiation public health emergency response planning. Pursuing this goal will benefit the population at large by considering those at greatest risk of health consequences after a radiological or nuclear mass casualty incident.

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Musculoskeletal Disorders

Mak

Wong

2023

Medical Radiology

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Teleradiotherapy of joints in rheumatoid arthritis: lack of efficacy

Cited by 4 publications

References 8 publications

The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit

The role of radiation treatment in the management of inflammatory musculoskeletal conditions: a revisit

Considerations of Medical Preparedness to Assess and Treat Various Populations During a Radiation Public Health Emergency

Musculoskeletal Disorders

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