Tell Me the Truth and I Will Not Be Harmed: Informed Consents and Nocebo Effects

Colloca, Luana

doi:10.1080/15265161.2017.1314057

Cited by 41 publications

(26 citation statements)

References 9 publications

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“…Training and education might include informing health professionals about the negative impact of nocebo effects, as well as training them in strategies for optimal verbal and non-verbal communication, including information about risks and side effects [7, 9-11, 35-37]. Again, however, there was acknowledgement that there has been a lack of research into the education and training of health professionals in relation to nocebo effects.…”

Section: Resultsmentioning

confidence: 99%

“…Experts agreed that nocebo effects should be explained to patients (C1) and that information about side effects should be presented in such a way that nocebo effects are minimized (C4). The relatively strong consensus regarding optimally informing patients to minimize nocebo effects might be due to its high clinical relevance, which is based on findings that nocebo effects have been shown to consistently worsen treatment outcomes and to be at least in part responsible for side effects [6, 10-12, 35]. Indeed, there is convincing evidence that the way in which patients are informed about risks and side effects influences the likelihood of their occurrence.…”

Section: Resultsmentioning

confidence: 99%

“…For example, tailored strategies might be applied after the necessary information has been offered, depending on the patient’s need for more detailed information on the risks and side effects of treatment. Such strategies might be particularly useful for those patients who have a high risk of developing nocebo effects, such as individuals who exhibit high levels of somatic amplification or fear of side effects [7, 10, 11, 35]. Moreover, evidence is needed about the consequences of systematically informing patients about the role of nocebo effects, for example, by introducing the terminology of nocebo effects, or determining the optimal moment for informing patients about nocebo effects during ongoing treatments [37].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

Evers

Colloca

Blease

et al. 2018

Psychother Psychosom

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386

420

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Background: Placebo and nocebo effects occur in clinical or laboratory medical contexts after administration of an inert treatment or as part of active treatments and are due to psychobiological mechanisms such as expectancies of the patient. Placebo and nocebo studies have evolved from predominantly methodological research into a far-reaching interdisciplinary field that is unravelling the neurobiological, behavioural and clinical underpinnings of these phenomena in a broad variety of medical conditions. As a consequence, there is an increasing demand from health professionals to develop expert recommendations about evidence-based and ethical use of placebo and nocebo effects for clinical practice. Methods: A survey and interdisciplinary expert meeting by invitation was organized as part of the 1st Society for Interdisciplinary Placebo Studies (SIPS) conference in 2017. Twenty-nine internationally recognized placebo researchers participated. Results: There was consensus that maximizing placebo effects and minimizing nocebo effects should lead to better treatment outcomes with fewer side effects. Experts particularly agreed on the importance of informing patients about placebo and nocebo effects and training health professionals in patient-clinician communication to maximize placebo and minimize nocebo effects. Conclusions: The current paper forms a first step towards developing evidence-based and ethical recommendations about the implications of placebo and nocebo research for medical practice, based on the current state of evidence and the consensus of experts. Future research might focus on how to implement these recommendations, including how to optimize conditions for educating patients about placebo and nocebo effects and providing training for the implementation in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Implications of Placebo and Nocebo Effects for Clinical Practice: Expert Consensus

Evers

Colloca

Blease

et al. 2018

Psychother Psychosom

Self Cite

386

420

View full text Add to dashboard Cite

show abstract

“…The negative counterpart of the placebo effect is named “nocebo” effect (Colloca, 2017a, 2017b; Klinger, Blasini, Schmitz, & Colloca, 2017), and despite its relevance for modulation of mechanisms and clinical implications, the nocebo phenomenon has received less attention over the past decades than the placebo effect. However, laboratory and translational research is unraveling some of the behavioral and biological mechanisms as well as the clinical implications.…”

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confidence: 99%

Preface

Colloca¹

2018

International Review of Neurobiology

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“…In clinical research, symptoms and complaints in patient populations, medication nonadherence, and need for additional drug prescriptions, among other topics, are often grouped together into a category called risk communication and framing effects. For example, the mere mention of headaches as a common side effect during risk communication for studies on antidepressants and other medications can increase the likelihood that headaches are experienced during the study (Blasini, Corsi, Klinger, & Colloca, 2017; Colloca, 2017a, 2017b; Klinger, Blasini, Schmitz, & Colloca, 2017). Risk communication also leads to an increased rate of withdrawal from the studies, making it difficult to recruit and retain study participants in clinical trials.…”

mentioning

confidence: 99%