Telocytes in ileum of the Chinese giant salamander: ultrastructural evidence

Zhang, Hui; Zhong, Shengwei; Ge, Tingting; Peng, Shasha; Yu, Peng; Zhou, Ziyan; Guo, Xiaoquan

doi:10.1111/jcmm.12741

Cited by 7 publications

(6 citation statements)

References 15 publications

(24 reference statements)

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“…Therefore, to study regeneration mechanisms, lower animals, for example amphibian, may be a better model animal than mammal. Our previous study has confirmed the presence of TCs in the ileum of an amphibian, Chinese giant salamander Andrias davidianus (Amphibia: Caudata) 25 . It is suggested that TCs also may exist in other organs of the amphibian.…”

supporting

confidence: 61%

“…Previous studies also demonstrated that TCs were located in the lamina propria of several animal organs, such as rat duodenum and jejunum, and A. davidianus ileum 4 11 25 . These investigations suggested that TCs may be involved in immune response, intercellular signaling, tissue homeostasis maintenance, and glandular cells secretion and renewal 2 4 11 25 29 . Generally, TCs are suggested to control growth and differentiation of other cell types, mainly stem/progenitor cells, and further regulate surrounding cells regeneration and tissue repair in a particular niche 1 9 30 .…”

Section: Discussionmentioning

confidence: 81%

“…TEM was conducted according to methods of Yang et al 23 and Zhang et al 25 . Small pieces of stomachs tissues were fixed in 2.5% glutaraldehyde/PBS (pH 7.4, 0.1 M) at 4 °C for 72 h, and then washed three times in 0.01 M PBS (pH 7.4).…”

Section: Methodsmentioning

confidence: 99%

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Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Zhang

Zhong

et al. 2016

Sci Rep

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In this study, we attempt to identify gastric telocytes (TCs) of the Chinese giant salamander Andrias davidianus, by light microscopy, immunohistochemistry and transmission electron microscopy (TEM) methods. Toluidine blue staining showed TCs with one to two very thin and long telopodes (Tps) that were located in gastric lamina propria. Tps had characteristic structures, including podoms, podomers and dichotomous branching. Immunohistochemistry showed the existence of CD34+/PDGFRα+ TCs with moniliform Tps in stroma and were close to gastric glands and blood vessels. TEM micrographs also demonstrated the presence of TCs in interstitium between gastric glands. TCs/Tps were located in close proximity to gastric glands, blood vessels, endocrine cells and stem cells. In particular, Tps frequently surrounded stem cells. TCs and Tps, Tps and stem cells established close contacts. Moreover, the exosomes were also found near TCs/Tps. Our data confirmed the presence of TCs in gastric lamina propria of the amphibian, and suggested that TCs cooperate with resident stem cells to regulate endocrine cells and gastric glands regeneration and homeostasis.

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supporting

confidence: 61%

Section: Discussionmentioning

confidence: 81%

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Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Zhang

Zhong

et al. 2016

Sci Rep

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“…Consequently, the amount of publications concerning telocytes has grown exponentially (Creoiu & Cretoiu, ). Telocytes are believed to be ubiquitously present and so far have been found in humans and various vertebrate animals such as mice, dogs, chickens and salamanders, where their presence was shown in different organs including heart (Hinescu, Gherghiceanu, Mandache, Ciontea, & Popescu, ; Suciu, Popescu, Regalia, Ardelean, & Manole, ; Gherghiceanu, Manole, & Popescu, ; Popescu et al., ; Yang, Sun, Wu, Xiao, & Kong, ), gut (Cantarero Carmona, Luesma Bartolomé, & Junguera Escribano, ; Cretoiu, Cretoiu, Simionescu, & Popescu, ; Zhang et al., ), liver (Xiao, Wang, Liu, & Yang, ), gallbladder (Hinescu, Ardeleanu, Gherghiceanu, & Popescu, ), parotid glands (Nicolescu, Bucur, Dinca, Rusu, & Popescu, ), exocrine pancreas (Nicolescu & Popescu, ), female reproductive system (Gherghiceanu & Popescu, ; Popescu et al., ; Suciu et al., ; Cretoiu, Cretoiu, & Popescu, ; Hatta, Huang, Weisel, & Li, ; Cretoiu, Cretoiu, Marin, Radu, & Popescu, ), prostate (Corradi et al., ), urinary system (Qi et al., ; Zheng, Zhu, Lin, Wu, & Wang, ; Vannucchi, Traini, Guasti, Del Popolo, & Faussone‐Pellegrini, ), respiratory system (Popescu, Gherghiceanu, Suciu, Manole, & Hinescu, ; Zheng et al., ; Rusu, Jianu et al., ), skin (Ceafalan, Gherghiceanu, Popescu, & Simionescu, ; Rusu, Mirancea et al., ), meninges and choroid plexus (Popescu, Gherghiceanu, Kostin, Ceafalan, & Popescu, ; Xu, Lu, & Zhang, ), skeletal muscle (Popescu, Manole, Serboiu et al., ; Suciu, Popescu, Kostin, & Popesu, ), eyes (Luesma, Gherghiceanu, & Popescu, ), bone marrow (Li, Zhang, Yang, Lu, & Ge, ), vasculature (Li, Lu, Liu, Ge, & Zhang, ), mesentery (Hinescu, Popescu, Gherghiceanu, & Faussone‐Pellegrini, ) and pleura (Hinescu, Gherghiceanu, Suciu, & Popescu, ).…”

Section: Introductionmentioning

confidence: 99%

Identification of telocytes in the porcine heart

Tay

Vandecasteele

Broeck

2017

Anat Histol Embryol

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Recently, a new interstitial cell type called telocyte has been identified. Telocytes are found in many organs including the heart, where they are especially well described. However, their presence in the porcine heart has not yet been proven. The pig is a valuable animal model in research because of its resemblance with man, making it interesting to determine whether telocytes can be found in pigs as well. The focus of this study is the identification and ultrastructural description of telocytes in the heart tissue of pig. Using transmission electron microscopy, telocytes were found in both left and right atrium and ventricle, usually close to cardiomyocytes and/or blood vessels. Their most important characteristic is the long cytoplasmic processes called telopodes, which have a moniliform aspect, measure tens of μm and usually have a thickness below 0.2 μm. This unique morphological feature enables telocytes to be recognized from other interstitial cells such as fibroblasts. Additional observations include the ability to release extracellular vesicles and to make contacts with other structures such as endothelial cells, suggesting a role in intercellular communication.

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“…In comparison with mammals, however, there are few investigations of TCs in lower animals. Our previous study has demonstrated the existence of TCs in the ileum of the Chinese giant salamander Andrias davidianus (Amphibia: Caudata) . To determine whether TCs are also present in other organs of the amphibian, further studies are required.…”

mentioning

confidence: 99%

Telocytes in pancreas of the Chinese giant salamander (Andrias davidianus)

Zhang

Zhong

et al. 2016

J Cellular Molecular Medi

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Telocytes (TCs), novel interstitial cells, have been identified in various organs of many mammals. However, information about TCs of lower animals remains rare. Herein, pancreatic TCs of the Chinese giant salamanders (Andrias davidianus) were identified by CD34 immunohistochemistry (IHC) and transmission electron microscopy (TEM). The IHC micrographs revealed CD34+ TCs with long telopodes (Tps) that were located in the interstitium of the pancreas. CD34+ TCs/Tps were frequently observed between exocrine acinar cells and were close to blood vessels. The TEM micrographs also showed the existence of TCs in the interstitium of the pancreas. TCs had distinctive ultrastructural features, such as one to three very long and thin Tps with podoms and podomers, caveolae, dichotomous branching, neighbouring exosomes and vesicles. The Tps and exosomes were found in close proximity to exocrine acinar cells and α cells. It is suggested that TCs may play a role in the regeneration of acinar cells and α cells. In conclusion, our results demonstrated the presence of TCs in the pancreas of the Chinese giant salamander. This finding will assist us in a better understanding of TCs functions in the amphibian pancreas.

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Telocytes in ileum of the Chinese giant salamander: ultrastructural evidence

Cited by 7 publications

References 15 publications

Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Telocytes in gastric lamina propria of the Chinese giant salamander, Andrias davidianus

Identification of telocytes in the porcine heart

Telocytes in pancreas of the Chinese giant salamander (Andrias davidianus)

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