Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour?

Hiyama, Eiso; Hiyama, Keiko; Ohtsu, Kazuhiro; Yamaoka, Hiroaki; Ichikawa, Toru; Shay, Jerry W.; Yokoyama, Takashi

doi:10.1016/s0959-8049(97)00226-8

Cited by 66 publications

(52 citation statements)

References 28 publications

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“…In childhood tumours, telomerase activity and hTERT mRNA expression were also detected in a majority of cases of neuroblastoma, retinoblastoma, and nephroblastoma. In neuroblastoma, we have already reported a significant correlation between high telomerase activity and poor outcomes of patients (Hiyama et al, 1995a(Hiyama et al, , 1997a. In retinoblastoma, telomerase activity was detected in about 50% of the tumours and such tumours showed a high recurrence rate (Gupta et al, 1996).…”

Section: Discussionmentioning

confidence: 97%

High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

et al. 2004

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Section: Discussionmentioning

confidence: 97%

High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

et al. 2004

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“…Typically, some stage-IVS neuroblastomas that subsequently regressed did not exhibit telomerase activity and showed shortened telomeres (Hiyama et al, 1995a(Hiyama et al, , 1997a. These results demonstrated that telomerase activity can be a useful marker for predicting outcome of the disease and for determining appropriate treatment for the patients with such tumors.…”

Section: Telomerase As a Prognostic Indicatormentioning

confidence: 88%

“…In a retrospective study of a large number of breast cancers, the levels of telomerase activity signi®cantly correlated with clinical outcomes and several prognostic indicators (Clark et al, 1997). ) Adult T-cell leukema Acute myelogenous leukemia Childhood tumor Neuroblastoma (Hiyama et al, 1995a(Hiyama et al, , 1997aPoremba et al, 1999b;Reynolds et al, 1996) Wilms tumor Oncogene Clinical utility of telomerase in cancer E Hiyama and K Hiyama…”

Section: Telomerase As a Prognostic Indicatormentioning

confidence: 99%

“…In neuroblastoma, one of the most common tumors in childhood, high telomerase activity correlated with poor outcome, while the tumors with low activity of this enzyme showed favorable outcome (Hiyama et al, 1995a(Hiyama et al, , 1997aPoremba et al, 1999b;Streutker et al, 2001). Typically, some stage-IVS neuroblastomas that subsequently regressed did not exhibit telomerase activity and showed shortened telomeres (Hiyama et al, 1995a(Hiyama et al, , 1997a.…”

Section: Telomerase As a Prognostic Indicatormentioning

confidence: 99%

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Clinical utility of telomerase in cancer

2002

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“…High levels of telomerase activity have been found to be associated with an advanced stage and a poor prognosis in leukemia, 8) neuroblastoma 9) and gastric cancer. 10) In contrast to many other human cancers, the significance of telomerase activity in relation to early diagnosis, staging and prognosis of nasopharyngeal carcinoma (NPC) has not been reported.…”

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confidence: 99%

Diagnostic Usefulness of Telomerase Activity in Nasopharyngeal Carcinoma

Hwang¹,

Su²,

Kou³

et al. 2000

Japanese Journal of Cancer Research

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Telomeres are specialized structures at the ends of eukaryotic chromosomes which are composed of simple repetitive G-rich hexameric sequences. Activation of telomerase, a ribonucleoprotein that synthesizes telomeric DNA, is found in most malignant tumors. However, little data is available concerning the correlation between telomerase activity and NPC (nasopharyngeal carcinoma). In this study, telomerase activation was determined using the TRAP (telomerase repeat amplification protocol) assay in 62 nasopharyngeal biopsies (25 NPC, 25 non-malignant nasopharyngeal lymphoid tissues, 12 post-irradiated nasopharyngeal tissues). The results showed that strong telomerase activity was present in both NPC and non-malignant nasopharyngeal biopsies. Post-irradiated nasopharyngeal samples had a significantly lower telomerase activity than NPC and non-malignant nasopharyngeal lymphoid tissues. It is well known that nasopharyngeal tissue is infiltrated by numerous lymphocytes, which might retain telomerase activity. Therefore, the finding that the telomerase activation was lowest in post-irradiated nasopharyngeal tissues is reasonable because of the destruction of activated lymphocytes and NPC by radiation. NPC biopsies with positive lymph node involvement exhibited higher levels of telomerase compared to those without lymph node involvement. Our data indicate a positive association between telomerase activity and tumor potential for lymphatic spreading in limited local tumors. In addition, telomerase activity may be useful as a diagnostic marker in the detection of tumor cells in recurrent NPC, but not in primary NPC.

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Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour?

Cited by 66 publications

References 28 publications

High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

High expression of telomerase is an independent prognostic indicator of poor outcome in hepatoblastoma

Clinical utility of telomerase in cancer

Diagnostic Usefulness of Telomerase Activity in Nasopharyngeal Carcinoma

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