Telomere length and 8-hydroxy-2-deoxyguanosine as markers for early prediction of Alzheimer disease

Abou-Elela, Dalia H; El-Edel, Rawhia H; Shalaby, Ahmed; Fouaad, Mariam A; Sonbol, Ahmed

doi:10.4103/psychiatry.indianjpsychiatry_783_19

Cited by 7 publications

(4 citation statements)

References 40 publications

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“…The 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the product of the interaction between oxygen-free radicals and the nucleobases of the DNA strand, such as guanine; thus, it is commonly considered a DNA damage marker [ 85 , 86 ] and is associated to carcinogenesis and degenerative diseases [ 87 , 88 , 89 ]. Thus, we wanted to compare the telomere length of the ovaries to the 8-OHdG serum levels.…”

Section: Resultsmentioning

confidence: 99%

“…The 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the product of the interaction between oxygen-free radicals and the nucleobases of the DNA strand, such as guanine; thus, it is commonly considered a DNA damage marker [85,86] and is associated to carcinogenesis and degenerative diseases [87][88][89]. Thus, we wanted to compare the telomere length This set of results suggests that Exocomplex ® treatment can efficiently contrast and balance the toxic effect of H 2 O 2 treatment, directly influencing immunoglobulins serum concentration.…”

Section: Exocomplex ® Administration Balances Cytotoxic Effect Induce...mentioning

confidence: 99%

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Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

et al. 2023

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Plant-derived exosomes (PDEs) are receiving much attention as a natural source of antioxidants. Previous research has shown that PDEs contain a series of bioactives and that their content varies depending on the fruit or vegetable source. It has also been shown that fruits and vegetables derived from organic agriculture produce more exosomes, are safer, free of toxic substances, and contain more bioactives. The aim of this study was to investigate the ability of orally administered mixes of PDE (Exocomplex®) to restore the physiological conditions of mice treated for two weeks with hydrogen peroxide (H2O2), compared with mice left untreated after the period of H2O2 administration and mice that received only water during the experimental period. The results showed that Exocomplex® had a high antioxidant capacity and contained a series of bioactives, including Catalase, Glutathione (GSH), Superoxide Dismutase (SOD), Ascorbic Acid, Melatonin, Phenolic compounds, and ATP. The oral administration of Exocomplex® to the H2O2-treated mice re-established redox balance with reduced serum levels of both reactive oxygen species (ROS) and malondialdehyde (MDA), but also a general recovery of the homeostatic condition at the organ level, supporting the future use of PDE for health care.

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Section: Resultsmentioning

confidence: 99%

“…The 8-hydroxy-2′-deoxyguanosine (8-OHdG) is the product of the interaction between oxygen-free radicals and the nucleobases of the DNA strand, such as guanine; thus, it is commonly considered a DNA damage marker [85,86] and is associated to carcinogenesis and degenerative diseases [87][88][89]. Thus, we wanted to compare the telomere length This set of results suggests that Exocomplex ® treatment can efficiently contrast and balance the toxic effect of H 2 O 2 treatment, directly influencing immunoglobulins serum concentration.…”

Section: Exocomplex ® Administration Balances Cytotoxic Effect Induce...mentioning

confidence: 99%

Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

et al. 2023

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“…Consistent with these data, elevated urinary 8-OHdG levels, a biomarker of smoking status [ 45 ], were associated with lower global cognitive scores in 45–75-year-old adults, after adjustment for age, education, and the genetic risk factors for age-related cognitive decline and Alzheimer’s disease apolipoprotein E4 [ 46 ]. Urinary 8-OHdG levels were used as a biomarker to distinguish Alzheimer’s patients from cognitively healthy controls [ 47 , 48 ]. Similarly, higher serum levels of 8-OH-dG 24 h after hospital admission were associated with early cognitive impairments, as assessed by the Mini-Mental State Exam 30 days later, in patients with stroke [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Cognitive Performance Following Exposure to Second-Hand Smoke (SHS) from Tobacco Products Associated with Oxidative-Stress-Induced DNA Damage and Repair and Disruption of the Gut Microbiome

Raber,

Stagaman,

Kasschau

et al. 2023

Genes

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Exposure to second-hand Smoke (SHS) remains prevalent. The underlying mechanisms of how SHS affects the brain require elucidation. We tested the hypothesis that SHS inhalation drives changes in the gut microbiome, impacting behavioral and cognitive performance as well as neuropathology in two-month-old wild-type (WT) mice and mice expressing wild-type human tau, a genetic model pertinent to Alzheimer’s disease mice, following chronic SHS exposure (10 months to ~30 mg/m3). SHS exposure impacted the composition of the gut microbiome as well as the biodiversity and evenness of the gut microbiome in a sex-dependent fashion. This variation in the composition and biodiversity of the gut microbiome is also associated with several measures of cognitive performance. These results support the hypothesis that the gut microbiome contributes to the effect of SHS exposure on cognition. The percentage of 8-OHdG-labeled cells in the CA1 region of the hippocampus was also associated with performance in the novel object recognition test, consistent with urine and serum levels of 8-OHdG serving as a biomarker of cognitive performance in humans. We also assessed the effects of SHS on the percentage of p21-labeled cells, an early cellular marker of senescence that is upregulated in bronchial cells after exposure to cigarette smoke. Nuclear staining of p21-labeled cells was more prominent in larger cells of the prefrontal cortex and CA1 hippocampal neurons of SHS-exposed mice than in sham-exposed mice, and there was a significantly greater percentage of labelled cells in the prefrontal cortex and CA1 region of the hippocampus of SHS than air-exposed mice, suggesting that exposure to SHS may result in accelerated brain aging through oxidative-stress-induced injury.

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“…Furthermore, chronic oxidative stress is linked to cardiovascular and chronic inflammatory diseases such as inflammatory bowel disease and diabetes type 2, and it is known that in subjects with such chronic diseases, telomeres shorten faster [ 10 , 15 , 16 ]. Decreased serum total antioxidant capacity (TAC), reduced LTL and increased plasma 8-OHdG concentrations have been found in patients with Alzheimer’s disease in comparison to an age-matched group of non-demented subjects [ 17 ]. Garcia et al showed a relation between the dietary total antioxidant capacity and the LTL in a child and adolescent population including both sexes [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length

Hassler

Almer²,

Reishofer

et al. 2021

Antioxidants

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Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel of 180 healthy athletic volunteers (90 males, 90 females) were measured Additionally, a questionnaire about sports behaviour and the type of training was completed. We observed a positive significant relation between serum LTL and TAC in the male group (cc = 3.4/p = 0.001) but not in females. There was no statistically significant correlation between age and physical activity and LTL in both groups. This is the first cross sectional study demonstrating an association between total serum TAC and LTL in healthy males, but interestingly, not in the females. Nevertheless, these results should be interpreted as preliminary, and further studies in independent cohorts are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity.

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Telomere length and 8-hydroxy-2-deoxyguanosine as markers for early prediction of Alzheimer disease

Cited by 7 publications

References 40 publications

Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

Oral Treatment with Plant-Derived Exosomes Restores Redox Balance in H2O2-Treated Mice

Behavioral and Cognitive Performance Following Exposure to Second-Hand Smoke (SHS) from Tobacco Products Associated with Oxidative-Stress-Induced DNA Damage and Repair and Disruption of the Gut Microbiome

Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length

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