Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia

Zekry, Dina; Herrmann, Françoís; Irminger-Finger, Irmgard; C, Graf; Genet, Chantal; Vitale, Anna-Maria; Michel, Jean‐Pierre; Gold, Gabriel; Krause, Karl‐Heinz

doi:10.1016/j.jns.2010.07.019

Cited by 47 publications

(31 citation statements)

References 30 publications

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“…The result of the present study is consistent with previous studies reporting a negative correlation between telomere length and age [3,5,16]. Previous studies reported an association between telomere length and risk of dementia [10], and the mean telomere length is shorter among AD patients when compared with control subjects [12]. However, the association between telomere length and cognitive outcomes in non-demented population was controversial [16,18].…”

Section: Discussionsupporting

confidence: 90%

“…Therefore, the measurement of telomere length reflects the replication history of cells, and the telomere length is associated with senescence and apoptosis [4]. The telomere length has been proposed as a biomarker for ageing [5] and associated with lifespan [6] and various age-related conditions such as cancer [7], cardiovascular disease [8], osteoporosis [9], vascular dementia [10] and AD [11]. AD patients had shorter telomere in peripheral blood lymphocytes, which was correlated with higher serum TNF concentration and higher percentage of heat-induced apoptosis in T cells [11].…”

Section: Introductionmentioning

confidence: 99%

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Telomere length and cognitive function in southern Chinese community-dwelling male elders

Lau

Suen

et al. 2013

Age and Ageing

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Background: telomere attrition has been associated with an increased risk of different age-related diseases and is widely accepted as a marker of cellular ageing. On the other hand, it is well known that cognitive function declines with age. The telomere length may therefore act as a marker for the pathway associated with cognitive function. Methods: we examined telomere length and cognitive functions in a community-dwelling Chinese male population aged 65 years and above living in Hong Kong. The telomere length was measured by quantitative real-time PCR in 976 men. Cognitive function was assessed by Chinese (Cantonese) version of Mini-Mental State Exam and Community Screening Interview for Dementia. Results: our result showed there was a significant association between telomere length, delayed recall (P = 0.007) and category verbal fluency (P = 0.048). These associations remained significant after adjustment for age and education. Further analysis using a cut-off score for MMSE, three-item recall and word list generation tests suggested that the telomere length was positively correlated with performance in these areas (P = 0.015). Conclusion: the findings support the association of telomere length and cognitive function and suggested that the telomere length may serve as a biological marker for cognitive decline.

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Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Telomere length and cognitive function in southern Chinese community-dwelling male elders

Lau

Suen

et al. 2013

Age and Ageing

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“…Telomeres shorten with each cell division and are further shortened by environmental factors including psychiatric conditions, inflammation, and oxidative stress [9]. In addition to these factors, telomere length decreases with age [10] and is further affected by age-related diseases including diabetes mellitus [11], dementia [12], and cancer [13]. Therefore, telomere length is considered a potential biomarker for monitoring aging and age-related processes [14].…”

Section: Introductionmentioning

confidence: 99%

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Jeeyon

Kim²,

Lee³

2017

Dement Geriatr Cogn Disord

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Background: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. Methods: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. Results: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). Conclusion: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults.

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“…OS can generate hydroxyl radicals, causing a wide range of DNA lesions, including base modifications, and yield products of DNA oxidation including 8-hydroxy-deoxyguanosine and O 6 -methylguanine [25]. Such lesions have been shown to interfere with the ability of DNA to function as a substrate for DNA methyltransferases, resulting in global hypomethylation [26,27]. As a result, genomic DNA, including the subtelomeric region, is hypomethylated.…”

Section: Discussionmentioning

confidence: 99%

Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease

Guan

Maeda

et al. 2013

Aging Clin Exp Res

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These results may indicate that AD contributes to the loss of cells bearing the shortest telomeres, with hypomethylation of subtelomeres occurring in addition to telomere attrition, resulting in an apparent normal mean telomere length in AD patients. The relatively high subtelomeric methylation status of the shortest telomeres in peripheral blood leukocytes may be a characteristic of AD. This report demonstrates that the epigenetic status of the telomeric region is affected by disease conditions.

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Telomere length and ApoE polymorphism in mild cognitive impairment, degenerative and vascular dementia

Cited by 47 publications

References 30 publications

Telomere length and cognitive function in southern Chinese community-dwelling male elders

Telomere length and cognitive function in southern Chinese community-dwelling male elders

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Analysis of telomere length and subtelomeric methylation of circulating leukocytes in women with Alzheimer’s disease

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