Telomere length in leukocytes and cervical smears of women with high-risk human papillomavirus (HR HPV) infection

Pańczyszyn, Anna; Boniewska-Bernacka, Ewa; Głąb, Grzegorz

doi:10.1016/j.tjog.2019.11.007

Cited by 10 publications

(8 citation statements)

References 28 publications

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“…This difference could be attributed to the relatively small sample size of the study by Panczyszyn et al [23] when compared to this study (88 vs. 287 samples). Another reason is that Panczyszyn et al [23] used blood samples, whereas this study used cervical samples.…”

Section: Discussioncontrasting

confidence: 58%

Relative Telomere Length in Cervical Exfoliated Cells among Women with High-Risk Human Papillomavirus

Al-Awadhi,

Alwehaidah,

AlRoomy

et al. 2023

Pathobiology

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Introduction: This study investigates and compares the relative telomere length (RTL) outcome of high-risk (hr) human papillomavirus (HPV)-infected normal, low-grade squamous intraepithelial lesion (LSIL), and high-grade squamous intraepithelial lesion (HSIL) cervical samples to HPV-free normal cervical samples. Methods: This study used archived cervical samples and obtained cytology and histology data. HPV genotyping was conducted using Sanger sequencing and RTL was performed using real-time quantitative polymerase chain reaction. Results: This study investigated 287 cervical samples, including 100 normal and hr-HPV-negative samples from the control group, 44 normal and hr-HPV-infected samples, and 143 SIL and hr-HPV-infected samples. The RTL in hr-HPV-infected samples, including the SIL and normal sample groups, were significantly longer than that in the control group. RTL in HSIL (5.13 ± 3.22) and LSIL (2.86 ± 2.81) were significantly different (P < 0.001). The RTL of cervical intraepithelial neoplasia (CIN1) lesion (3.53 ± 2.53) differed significantly (P < 0.001) when compared to CIN2 and CIN3 lesions combined. The risk of developing cervical cancer was associated with RTL and was decreased with RTL. Conclusion: This study revealed the strong potential of the RTL test in identifying women at risk of developing cervical cancer.

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Section: Discussioncontrasting

confidence: 58%

Relative Telomere Length in Cervical Exfoliated Cells among Women with High-Risk Human Papillomavirus

Al-Awadhi,

Alwehaidah,

AlRoomy

et al. 2023

Pathobiology

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“…This correlates with dysplasia and telomerase activity. Furthermore, it increases with the progression of lesions [20,[33][34][35][36][37].…”

Section: Primer/oligomer Sequencementioning

confidence: 97%

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells

Albosale

Машкина

2021

Balkan Journal of Medical Genetics

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Importunate high-risk HPV (HR-HPV) infection is the most common trigger for the cervical carcinogenesis process. In this respect, the presence of cancer can be imputed to telomere lengthening or shortening. This paper explores the possible correlation between relative telomere length and viral load in two groups of women, namely: those with high-risk HPV infection and those who do not have this infection. Thus, samples comprising of 50 women in each group were evaluated for this research. The Amplisens HPV HCR screen-titre-FRT PCR kite was employed for quantitative analysis. Relative telomere length was quantified by real-time PCR. In each of the two HPV load groups, there was no correlation between age and telomere length. Telomere shortening was found in the cervical cell samples of women with high HPV loads, compared with women in the control group. Telomere shortening is associated with elevated HPV loads.

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“…While some infections have been studied in relation to telomere length, existing studies differ in the types and severities of infections studied, definitions used and use differing measures of telomere length, making pooling evidence across studies challenging 9 11–15…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, cross-sectional studies are the most abundant study type in this field; meaning there is a potential for reverse causality. Despite the heterogeneity, some evidence suggests that associations between some persistent viral infections such as cytomegalovirus and herpes simplex virus type-1 were associated with reduced telomere length or telomere attrition 9 10 12 13 15. Current gaps in research include establishing whether infections as a whole are risk factors for reduced telomere length and whether pathogen type, severity and infection site are associated with telomere length.…”

Section: Introductionmentioning

confidence: 99%

Infection and telomere length: a systematic review protocol

Tunnicliffe,

Muzambi,

Bartlett

et al. 2024

BMJ Open

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IntroductionTelomeres are a measure of cellular ageing with potential links to diseases such as cardiovascular diseases and cancer. Studies have shown that some infections may be associated with telomere shortening, but whether an association exists across all types and severities of infections and in which populations is unclear. Therefore we aim to collate available evidence to enable comparison and to inform future research in this field.Methods and analysisWe will search for studies involving telomere length and infection in various databases including MEDLINE (Ovid interface), EMBASE (Ovid interface), Web of Science, Scopus, Global Health and the Cochrane Library. For grey literature, the British Library of electronic theses databases (ETHOS) will be explored. We will not limit by study type, geographical location, infection type or method of outcome measurement. Two researchers will independently carry out study selection, data extraction and risk of bias assessment using the ROB2 and ROBINS-E tools. The overall quality of the studies will be determined using the Grading of Recommendations Assessment, Development and Evaluation criteria. We will also evaluate study heterogeneity with respect to study design, exposure and outcome measurement and if there is sufficient homogeneity, a meta-analysis will be conducted. Otherwise, we will provide a narrative synthesis with results grouped by exposure category and study design.Ethics and disseminationThe present study does not require ethical approval. Results will be disseminated via publishing in a peer-reviewed journal and conference presentations.PROSPERO registration numberCRD42023444854.

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Telomere length in leukocytes and cervical smears of women with high-risk human papillomavirus (HR HPV) infection

Cited by 10 publications

References 28 publications

Relative Telomere Length in Cervical Exfoliated Cells among Women with High-Risk Human Papillomavirus

Relative Telomere Length in Cervical Exfoliated Cells among Women with High-Risk Human Papillomavirus

Association of Relative Telomere Length and Risk of High Human Papillomavirus Load in Cervical Epithelial Cells

Infection and telomere length: a systematic review protocol

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