2008
DOI: 10.1016/j.bbrc.2007.12.078
|View full text |Cite
|
Sign up to set email alerts
|

Telomere length inversely correlates with radiosensitivity in human carcinoma cells with the same tissue background

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

3
16
0

Year Published

2009
2009
2015
2015

Publication Types

Select...
8
1

Relationship

1
8

Authors

Journals

citations
Cited by 26 publications
(19 citation statements)
references
References 32 publications
3
16
0
Order By: Relevance
“…Our results from earlier studies indicated that telomere length was inversely correlated with radiosensitivity in human carcinoma cells (8)(9)(10), which is consistent with other studies showing that there is an association between telomere length and radiosensitivity in human cells (11)(12)(13). Indeed, radiosensitive human cells show shorter telomeres than normal cells, and short telomeres increase cell radiosensitivity, so telomere has great appeal as a clinical target.…”
Section: Discussionsupporting
confidence: 81%
“…Our results from earlier studies indicated that telomere length was inversely correlated with radiosensitivity in human carcinoma cells (8)(9)(10), which is consistent with other studies showing that there is an association between telomere length and radiosensitivity in human cells (11)(12)(13). Indeed, radiosensitive human cells show shorter telomeres than normal cells, and short telomeres increase cell radiosensitivity, so telomere has great appeal as a clinical target.…”
Section: Discussionsupporting
confidence: 81%
“…Cells in G2/M are most sensitive and cells in S phase are mostly radioresistant, which may partially account for the increase in the radioresistance of Hep-2R cells induced by radiation. Furthermore, the magnitude of G2 delay has been shown to detect the degree of radiation-induced DNA damage and cellular radiosensitivity (7), it may be speculated that Hep-2R had less residual DNA damage due to longer telomere length than Hep-2, which was consistent with our previous research suggesting that short telomere length may lead to an impaired DNA repair (8).…”
Section: Discussionsupporting
confidence: 89%
“…A great number of studies manifest that cellular radiosensitivity is related to the cellular reproductive ability, so there should be some kind of intrinsic correlation between the telomere length and radiosensitivity (11)(12)(13). Our previous research also indicated that radiosensitivity is negatively correlated with telomere length, the longer the telomere length, the lower the radiosensitivity (8). Telomere maintenance has been implicated in cancer and ageing, and requires cooperation between a multitude of telomeric factors, including telomerase, TRF1, TRF2, RAP1, TIN2, Tankyrase, PINX1 and POT1 (14)(15)(16).…”
Section: Discussionmentioning
confidence: 99%
“…The HBV transcriptional transactivator oncoprotein HBV stimulates viral gene and cellular transformation of hepatocytes. HBV increases telomerase expression and activity in hepatoma cells [69]. Nonetheless, hepatocellular carcinomas have shortened telomeres.…”
Section: Telomere Length and Gastrointestinal Tract Cancersmentioning
confidence: 99%