Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study

Spigoni, Valentina; Aldigeri, Raffaella; Picconi, Angela; Derlindati, Eleonora; Franzini, Laura; Haddoub, Silvia; Prampolini, Giorgia; Vigna, Giovanni Battista; Zavaroni, Ivana; Bonadonna, Riccardo C.; Dei, Alessandra

doi:10.1007/s00592-016-0857-x

Cited by 17 publications

(6 citation statements)

References 31 publications

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“…In the Cox regression analysis using z score of rLTL and other risk factors for predicting CVD, the effect size of rLTL was similar to that of HbA 1c per SD change in risk factor. Other reports have demonstrated an association of rLTL with CVD risk factorsd including elevated LDL-C, raised blood pressure, poor glucose control, and carotid intima-media thicknessdin patients with diabetes (27,28). Cross-sectional studies of patients with type 2 diabetes showed that patients with previous MI or atherosclerotic plaques had shorter rLTL than did those without either (8,9,12).…”

Section: Discussionmentioning

confidence: 89%

Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register

et al. 2020

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Several studies support potential links between relative leukocyte telomere length (rLTL), a biomarker of biological aging, and type 2 diabetes. This study investigates relationships between rLTL and incident cardiovascular disease (CVD) in patients with type 2 diabetes. RESEARCH DESIGN AND METHODSConsecutive Chinese patients with type 2 diabetes (N 5 5,349) from the Hong Kong Diabetes Register for whom DNA obtained at baseline was stored and follow-up data were available were studied. rLTL was measured by using quantitative PCR. CVD was diagnosed on the basis of ICD-9 code. RESULTSMean follow-up was 13.4 years (SD 5.5 years). rLTL was correlated inversely with age, diabetes duration, blood pressure, HbA 1c , and urine albumin-to-creatinine ratio (ACR), and positively with estimated glomerular filtration rate (eGFR) (all P < 0.001). Subjects with CVD at baseline had a shorter rLTL (4.3 6 1.2 DDCt) than did subjects without CVD (4.6 6 1.2 DDCt) (P < 0.001). Of the 4,541 CVD-free subjects at baseline, the 1,140 who developed CVD during follow-up had a shorter rLTL (4.3 6 1.2 DDCt) than those who remained CVD-free after adjusting for age, sex, smoking, and albuminuria status (4.7 6 1.2 DDCt) (P < 0.001). In Cox regression models, shorter rLTL was associated with higher risk of incident CVD (for each unit decrease, hazard ratio 1.252 [95% CI 1.195-1.311], P < 0.001), which remained significant after adjusting for age, sex, BMI, systolic blood pressure, LDL cholesterol, HbA 1c , eGFR, and ACR (hazard ratio 1.141 [95% CI 1.084-1.200], P < 0.001). CONCLUSIONSrLTL is significantly shorter in patients with type 2 diabetes and CVD, is associated with cardiometabolic risk factors, and is independently associated with incident CVD. Telomere length may be a useful biomarker for CVD risk in patients with type 2 diabetes.

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Section: Discussionmentioning

confidence: 89%

Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register

et al. 2020

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“…Studies have proved that telomere length acts as an independent predictor of atherosclerosis, which is an early marker of vascular burden. [ 39 ] Other studies have suggested that there is a close relationship between carotid atherosclerosis and the occurrence of progressive ischemic stroke. [ 40 ] Besides, telomere length plays an important role in different stages of atherosclerosis, which is likely to cause stroke.…”

Section: Discussionmentioning

confidence: 99%

Relationship between short telomere length and stroke

et al. 2018

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Background:Several epidemiological studies had been carried out in different population cohorts to estimate the relationship between the shortened telomere length and stroke. However, the results still remained dispute. Consequently, we conducted this meta-analysis to estimate the relationship between them.Methods:PubMed, EMBASE, and Web of Science were systematically searched for related articles to evaluate the association between “stroke” and “telomere length. STATA 12.0 software was used to perform the meta-analysis. The Cochran Q test and inconsistency index (I2) were used to assess the heterogeneity. Begg funnel plot and Egger test were used to assess publication bias.Results:The meta-analysis was composed of 11 studies, consisting of 25,340 participants. We found a significant relationship between shortened telomere length and stroke (OR: 1.50, 95% CI: 1.13–2.0; P = .005); however, in the prospective and retrospective study subgroup, we did not find a statistical significant relationship between shortened telomere length and stroke (the prospective subgroup: OR: 1.41, 95% CI: 1–1.98; P = .051) (the retrospective subgroup: OR: 1.89, 95% CI: 0.96–3.72; P = .067).

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“…Indeed, vascular telomere length is lower in T2D patients ( 162 ). This is also important as a recent cross-sectional study demonstrated that telomere length is independently associated with subclinical atherosclerosis in subjects with T2D ( 152 ). However, accelerated telomere attrition was recently reported in circulating leukocytes, but not arteries, in T2D compared to control rats ( 156 ).…”

Section: Accelerated Vascular Aging In Diabetesmentioning

confidence: 98%

Epigenetics and Immunometabolism in Diabetes and Aging

Guzik

Cosentino

2018

Antioxidants & Redox Signaling

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Significance: A strong relationship between hyperglycemia, impaired insulin pathway, and cardiovascular disease in type 2 diabetes (T2D) is linked to oxidative stress and inflammation. Immunometabolic pathways link these pathogenic processes and pose important potential therapeutic targets.Recent Advances: The link between immunity and metabolism is bidirectional and includes the role of inflammation in the pathogenesis of metabolic disorders such as T2D, obesity, metabolic syndrome, and hypertension and the role of metabolic factors in regulation of immune cell functions. Low-grade inflammation, oxidative stress, balance between superoxide and nitric oxide, and the infiltration of macrophages, T cells, and B cells in insulin-sensitive tissues lead to metabolic impairment and accelerated aging.Critical Issues: Inflammatory infiltrate and altered immune cell phenotype precede development of metabolic disorders. Inflammatory changes are tightly linked to alterations in metabolic status and energy expenditure and are controlled by epigenetic mechanisms.Future Directions: A better comprehension of these mechanistic insights is of utmost importance to identify novel molecular targets. In this study, we describe a complex scenario of epigenetic changes and immunometabolism linking to diabetes and aging-associated vascular disease. Antioxid. Redox Signal. 29, 257–274.

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Telomere length is independently associated with subclinical atherosclerosis in subjects with type 2 diabetes: a cross-sectional study

Abstract: LTL is an independent predictor of subclinical atherosclerosis pointing to a role of LTL as an early marker of vascular burden and cardiovascular disease also in type 2 diabetes.

Cited by 17 publications

References 31 publications

Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register

Shortened Relative Leukocyte Telomere Length Is Associated With Prevalent and Incident Cardiovascular Complications in Type 2 Diabetes: Analysis From the Hong Kong Diabetes Register

Relationship between short telomere length and stroke

Epigenetics and Immunometabolism in Diabetes and Aging

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