Telomeres and essential hypertension

Ma, Lina; Li, Yun; Wang, Jieyu

doi:10.1016/j.clinbiochem.2015.07.013

Cited by 17 publications

(11 citation statements)

References 38 publications

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“…Our findings were similar to another related study on an association in PES and control groups ( 6 ), but our study is the first to report in humans that exposure to earthquake stress in different trimesters during pregnancy is associated with a shorter LTL. “Biological embedding” is commonly proposed as possible potential mechanism to explain how fetal development adversely affect health, such as prenatal stress and developmental programming leading to adult cardiometabolic disease ( 34 , 35 ), and telomere length may be the basis for this association ( 12 , 36 , 37 ). A study suggested that a shorter LTL in adulthood largely contributes to crucial factors that exert their influence during the fetal period ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Wang

et al. 2017

Front. Psychiatry

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Leukocyte telomere length (LTL) is a predictor of age-related diseases, cancer, and even early mortality. Prenatal stress experience has been suggested to associate with short LTL and an increased disease risk in adult life. The present study aimed to evaluate the 39-year effects of prenatal earthquake stress (PES) exposure on LTL and increased age-related disease risk in adulthood. Here, we compared the LTL in the subjects who were exposed to PES to healthy controls (CN) and evaluated whether stress exposure at different times during pregnancy is associated with a shorter LTL and long-term health conditions in adulthood. LTL was measured in 100 adults who experienced the 1976 7.8 Richter scale Tangshan earthquake of the Hebei province in utero and divided them into first, second, and third trimester groups according to the exposure timing during pregnancy. A total of 80 healthy volunteers from Shijiazhuang of the Hebei province were also assessed for their LTL. The telomere-to-single copy gene (T/S) ratio of the PES group (0.78 ± 0.06, p = 0.04) showed a significantly lower LTL than the CN group (0.97 ± 0.08). The results of the LTL analysis indicated that the subjects who experienced PES in the second (0.69 ± 0.09, p = 0.04) or third trimester (0.67 ± 0.76, p = 0.02) showed significantly shorter LTLs compared with those in the first trimester group (0.99 ± 0.12). A fully adjusted regression model indicated the same conclusions. In addition, we found that systolic pressure (SBP; 129.32 ± 14.86 mmHg, p = 0.041), body mass index (BMI; 22.54 ± 2.71, p = 0.046), and low-density lipoprotein (LDL; 3.09 ± 0.98 mmol/L, p = 0.048) in the subjects with PES were significantly higher than those measurements in the CN subjects (SBP; 122.06 ± 10.55 mmHg; BMI; 20.24 ± 2.13; LDL; 2.91 ± 0.76 mmol/L), and there was a significant negative correlation between an increased adult hypertension risk and a shorter LTL.

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Section: Discussionmentioning

confidence: 99%

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Wang

et al. 2017

Front. Psychiatry

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“…In addition, studies on diseases' risk factors, such as obesity, lipid profiles and hypertension have shown some inconsistent results. However, new evidences of correlation of these factors with TL are arising (59)(60)(61). The determination of epigenetic regulation of TL homeostasis with or without life style risk factors (eg obesity and smoking) remains an interesting area to be explored in telomeres biology (62)(63)(64), especially since genetic and epigenetic alterations seem important for a normal cell to suppress the telomere attrition and become malignant (65).…”

Section: Determinants Of Tlmentioning

confidence: 99%

The future of telomere length in personalized medicine

Visvikis‐Siest¹

2018

Front Biosci

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Telomere length has been subject of studies for many decades, aiming to elucidate its role in physiological processes, in process of aging and in diverse pathologies. Yet today, there is still no "big title" discovery that would lead to a practical use of telomeres as a reliable biomarker or target for a new drug. However, therapies for chronic disease patients are being tested and companies are already offering commercial tests for telomere length measurement. The strong genetic heritability of telomeres is opening the place for pharmacogenomics researches that could promote the personalized treatment of diverse diseases. In this article, we present the recent knowledge of telomeres genetic determination obtained by genome-wide association studies (GWAS), important biomarkers related to telomere length and review the possibilities of telomere's practical implementation in the medical treatment of diverse diseases and as a potential biomarker in personalized medicine. Furthermore, we summarise commercial offers of telomere length measurements available and we discuss the actions that should be taken to make steps forward into final application of the accumulated knowledge into practical use.

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“…In our previous review, we reported that telomeres and telomerase activity have played an important role in the occurrence and development of hypertension in both animal and human studies. 10 Short leukocyte telomere length (LTL) and low telomerase activity are associated with plaque instability, leading to senescent cell accumulation and finally contributing to heart failure. 11 Another study of patients with hypertension showed that a higher apnea-hypopnea index in polysomnographic examinations was associated with lower telomerase activity.…”

Section: Introductionmentioning

confidence: 99%

Telomere length and associated factors in older adults with hypertension

Liu

Zhang

2019

J Int Med Res

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Telomeres and telomerase play important roles in the occurrence and development of hypertension. This review was performed to clarify the factors that influence telomere length and telomerase activity in older patients and elucidate the association of these factors with hypertension. A PubMed search and critical review of studies assessing the risk factors underlying the association of hypertension with telomere length and telomerase activity was performed. Telomere length and telomerase activity were found to be associated with hypertension. The factors that influence telomere length and telomerase activity in older patients with hypertension include genetics, demographics, social and environmental factors, chronic disease, psychological factors, and antihypertensive drug treatment. A better understanding of the molecular mechanisms underlying the association of hypertension with telomere length and telomerase activity may help to reduce the incidence of hypertension.

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Telomeres and essential hypertension

Cited by 17 publications

References 38 publications

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

Earthquake Experience at Different Trimesters during Pregnancy Is Associated with Leukocyte Telomere Length and Long-term Health in Adulthood

The future of telomere length in personalized medicine

Telomere length and associated factors in older adults with hypertension

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