Temazepam as premedication in elderly patients

Clark, G. Heather; Erwin, Diana; Yate, P.M.; Burt, D. E. R.; Major, E.

doi:10.1111/j.1365-2044.1982.tb01152.x

Cited by 11 publications

(4 citation statements)

References 6 publications

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“…Our general opinion is that temazepam is a useful premedicant when given either on the evening before surgery or 1.5-2 hours before surgery, decreasing the patients' anxiety and fear. It provides a rapid but short duration of action, facilitating rapid postoperative recovery (51)(52)(53). Consequently, temazepam appears to be preferable to longer acting benzodiazepines for short operative procedures when rapid recovery and swift return to fitness are essential ( Table 3).…”

Section: Temazepam the Night Before Surgerymentioning

confidence: 99%

“…Temazepam has proved to be a useful sedative-anxiolytic agent in children (54), adults (4548, 51, 52) and the elderly (53). When administered in a novel dosage form (Expidet@ Wyeth) which dissolves instantaneously on contact with the tongue, temazepam 0.5 mg/kg produced satisfactory sedation and anxiolysis with few side-effects in 93.6 percent of children between 4 and 11 years of age (54).…”

Section: Temazepam the Night Before Surgerymentioning

confidence: 99%

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The use of oral benzodiazepines as premedications: the usefulness of temazepam

Kanto

1986

Acta Psychiatr Scand

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The primary aim of premedication is to relieve the patient's anxiety/restlessness before anaesthesia and to ensure optimum quantity and quality of sleep on the night preceding surgery. With these objectives in mind, oral benzodiazepines offer a good alternative to traditional parenteral premedicants, especially as the clear anxiolytic and sedative effects of the former are of great clinical value.Oral temazepam has proven to be a valuable premedicant given on the evening before operation andor the following morning, before surgery. Administered as a sedative in a single 20 mg oral dose the night before surgery, temazepam provided a good night's sleep in 77 percent of gynaecological surgical patients; patients slept for 7.6 hours and had no significant residual effects. As a premedicant, temazepam was as effective as parenteral diazepam or papaveretum. Temazepam's short duration of action facilitates rapid postoperative recovery in children, adults, and in the elderly. Thus, it is indicated especially for short operative procedures when rapid recovery and swift return to fitness are essential.Collins (1) has concluded that the aim of premedication is to establish mental and emotional relaxation, reduce sensory input and metabolic rate, and antagonize adverse reactions of the autonomic nervous system.

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Section: Temazepam the Night Before Surgerymentioning

confidence: 99%

Section: Temazepam the Night Before Surgerymentioning

confidence: 99%

The use of oral benzodiazepines as premedications: the usefulness of temazepam

Kanto

1986

Acta Psychiatr Scand

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“…Because of central depression, and even confusion, the use of strong sedative premedicants has been abandoned by some anaesthesists (4). Generally, however, patients expect sedative premedication as a necessary part of their anaesthesia (5).…”

mentioning

confidence: 99%

“…In earlier studies oral temazepam has proved an excellent sedative anxiolytic benzodiazepine for premedication in minor gynaecological and urological surgery, gastrointestinal endoscopy, bronchoscopy and in a variety of day-case surgery where a short duration of action facilitating a rapid postoperative recovery is desirable (5)(6)(7)(8)(9)(10). The use of oral temazepam in elderly patients has also been suggested, primarily because of its good sedative-anxiolytic properties and short duration (5). It is expected to cause few postoperative problems due to its short elimination phase half-life and lack of active metabolites (1 1, 12).…”

mentioning

confidence: 99%

Oral temazepam as a premedicant in elderly general surgical patients

Salonen

Kanto

Hovi-Viander

et al. 1986

Acta Anaesthesiol Scand

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In elderly, general surgical patients, oral temazepam 20 mg given in a soft gelatin capsule proved to be a useful light premedicant when given before spinal anaesthesia. In comparison with placebo, it caused preoperative subjective sedation, prevented an increase in heart rate and decreased serum cortisol, but not serum antidiuretic hormone levels. However, simple devices (linear analogue scale, Maddox wing test, critical flicker fusion apparatus) appeared to be quite ineffective in differentiating the clinical effects of temazepam from those of placebo. Temazepam given in a soft gelatin capsule to patients in the supine position had a reasonably fast gastrointestinal absorption, but its blood-lumbar cerebrospinal fluid penetration rate appeared to be quite slow.

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Plasma and cerebrospinal fluid concentrations of temazepam following oral drug administration

Badcock

Osborne

Nyman

et al. 1990

Eur J Clin Pharmacol

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Thirteen male patients were administered 20 mg of temazepam orally 1 to 2 h prior to undergoing spinal anaesthesia for a urological procedure. Samples of blood and CSF were drawn just before insertion of the spinal and the concentration of drug estimated in these two media. The results obtained indicated that a highly significant correlation existed between the unbound concentration of temazepam in plasma and the concentration of drug present in CSF. Temazepam appeared to be an effective light pre-medicant in all of the subjects studied.

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Temazepam as premedication in elderly patients

Abstract: SummaryOne hundred and jorty,five men were rundom1.y allocated on u double-blind busis 10

Cited by 11 publications

References 6 publications

The use of oral benzodiazepines as premedications: the usefulness of temazepam

The use of oral benzodiazepines as premedications: the usefulness of temazepam

Oral temazepam as a premedicant in elderly general surgical patients

Plasma and cerebrospinal fluid concentrations of temazepam following oral drug administration

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