Temocillin Concentrations in Human Tissues1

Gould, Jay; Meikle, G.; Cooper, D L; Horton, R.

doi:10.2165/00003495-198500295-00034

Cited by 8 publications

(2 citation statements)

References 1 publication

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“…Pharmacokinetics are similar to ticarcillin. Temocillin distributes well to most tissues and has relatively high protein binding (70–85%) (Gould et al, 1985). It is primarily eliminated in the urine through glomerular filtration and tubular secretion.…”

Section: Treatment Options For Crementioning

confidence: 99%

Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes

Duin

Kaye

Neuner

et al. 2013

Diagnostic Microbiology and Infectious Disease

303

200

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The emergence of carbapenem resistance in Enterobacteriaceae is an important threat to global health. Reported outcomes of infections with carbapenem-resistant Enterobacteriaceae (CRE) are poor. Very few options remain for the treatment of these virulent organisms. Antibiotics which are currently in use to treat CRE infections include aminoglycosides, polymyxins, tigecycline, fosfomycin, and temocillin. In addition, the role of combination therapy, including carbapenem containing regimens, remains to be defined. There are several important concerns regarding all of these treatment options such as limited efficacy, increasing reports of resistance, and specific toxicities. Data from retrospective studies favor combination therapy over single-agent therapy for the treatment of CRE bloodstream infections. In summary, new antibiotics are greatly needed, as is additional prospective research.

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Section: Treatment Options For Crementioning

confidence: 99%

Carbapenem-resistant Enterobacteriaceae: a review of treatment and outcomes

Duin

Kaye

Neuner

et al. 2013

Diagnostic Microbiology and Infectious Disease

303

200

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“…Gould et al [13] administered temocillin as a single intravenous bolus injection of 1 or 2 g 3-4 h prior to tissue sampling. Peak levels of temocillin in the prostatic tissue were found after 3 h and 45 min at 4.7 mg/kg.…”

Section: Temocillinmentioning

confidence: 99%

Penetration of Antimicrobial Agents into the Prostate

et al. 2003

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In the present review article, the penetration of antimicrobial agents into prostatic fluid and tissue was examined. Three major factors determining the diffusion and concentration of antimicrobial agents in prostatic fluid and tissue are the lipid solubility, dissociation constant (pKa) and protein binding. The normal pH of human prostatic fluid is 6.5–6.7, and it increases in chronic prostatitis, ranging from 7.0 to 8.3. A greater concentration of antimicrobial agents in the prostatic fluid occurs in the presence of a pH gradient across the membrane separating plasma from prostatic fluid. Of the available antimicrobial agents, β-lactam drugs have a low pKa and poor lipid solubility, and thus penetrate poorly into prostatic fluid, expect for some cephalosporins, which achieve greater than or equal to the inhibitory concentration. Good to excellent penetration into prostatic fluid and tissue has been demonstrated with many antimicrobial agents, including tobramycin, netilmicin, tetracyclines, macrolides, quinolones, sulfonamides and nitrofurantoin.

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