Tempe, Tofu, and Amyloid-β 1–40 Serum Levels in Ovariectomized Rats

Kridawati, Atik; Hardinsyah, Hardinsyah; Sulaeman, Ahmad; Rahardjo, Tri Budi W.; Hogervorst, Eef

doi:10.3233/jad-200220

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Researchers have found that consuming tempeh increases beneficial bacteria in the human intestinal tract [6, 7]. Correlations between tempeh consumption and brain function have also been observed in previous animal studies [8, 9]. Interestingly, Hogervorst et al [10] found that consumption of tofu (a non-fermented soy product) in older Indonesian adults has shown to increase risk of dementia and memory problems, although tempeh consumption seemed to offset this effect.…”

Section: Introductionmentioning

confidence: 78%

“…Second, tempeh supplementation modulates cognitive function through the change in Aβ level, which promotes neuron damage in Alzheimer-related processes. Kridawati et al [9] reported that tempeh and tofu flour supplementation in Sprague-Dawley rats reduced their Aβ level significantly at 2- and 5-week intervals, which is not found in the casein control group [10]. These previous studies also demonstrated that both supplementation of tempeh or the intended microbiota resulted in positive effect on cognitive function [10, 23, 25, 27].…”

Section: Discussion/conclusionmentioning

confidence: 99%

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Tempeh Consumption and Cognitive Improvement in Mild Cognitive Impairment

Handajani

Turana

Yogiara

et al. 2020

Dement Geriatr Cogn Disord

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Introduction: Tempeh consumption has been linked to the improvement of cognitive function in older people. However, to what extent the amount of microorganism or the size of tempeh serving consumed per day influences the benefit to cognitive functions has not yet been studied. Methods: This experimental study involved a total of 90 respondents, who were divided into 3 groups: group A (consuming 100 g of Tempeh A/day), group B (consuming 100 g of Tempeh B/day), and group C (control). Intervention was given for 6 months. Cognitive assessments were done before and after the intervention. Blood uric acid level was checked at the end of intervention to examine the effect of tempeh consumption on this. The inclusion criteria were respondents aged 60 years or over with mild cognitive impairment (MCI) who agreed not to consume other fermented food during the study period. Respondents with diabetes were excluded. Results: There were 84 subjects at the end of the study, majority being female (71.4%) and aged over 65 years (72.6%). An increase in global cognitive scores was found in both groups A and B. The increase in language domain scores was found only in group A. Conclusion: Both Tempeh A or Tempeh B consumption for 6 months appeared to be beneficial in improving global cognitive function of older people with MCI. Consuming Tempeh A, which had a lower number of microorganisms, was also associated with an improvement in the language domain.

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Section: Introductionmentioning

confidence: 78%

Section: Discussion/conclusionmentioning

confidence: 99%

Tempeh Consumption and Cognitive Improvement in Mild Cognitive Impairment

Handajani

Turana

Yogiara

et al. 2020

Dement Geriatr Cogn Disord

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“…In a previous study, consumption of tempeh for 6 months was found to significantly increase cognitive function in the elderly population group with mild cognitive impairment (MCI) (Handajani et al, 2020). Animal studies found that the extract from tempeh can affect brain function through its role in the gastrointestinal system (Hamad et al, 2016;Kridawati et al, 2020). In a study comparing the administration of tempeh and soy milk for 28 days, Stephanie et al (2018) found that tempeh consumption modulated gut microbiota, increasing amounts of Bifidobacterium and A. muciniphila.…”

Section: Probiotics and Cognitive Functionmentioning

confidence: 99%

Effects of Tempeh Probiotics on Elderly With Cognitive Impairment

Handajani

Turana²,

Yogiara³

et al. 2022

Front. Aging Neurosci.

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IntroductionOral consumption of probiotics can alter Gut Microbiota by causing changes in the production of probiotic derivatives. Therefore, by utilizing Gut-Brain-Axis (GBA), probiotics could provide an opportunity for central nervous system (CNS) modulation, including cognitive function. Tempeh is a traditional Indonesian food rich in probiotics and beneficial for cognitive function. However, the type of probiotics that play a role in cognitive improvement and the number of probiotics needed for the benefits of increasing cognitive function was unknown.MethodThis experimental study involved a total of 93 subjects, divided into 3 groups: A, B and C/control (n: 33, 32, and 28), who were provided with probiotic supplementation isolated from tempeh for 12 weeks intervention. Inclusion criteria were age > 60 years, and memory impairment with the third repetition value of Word List Memory Immediate Recall (WLMIR) < 7. Subjects with diabetes were excluded. Cognitive function examinations were carried out before and after treatment. The tempeh-derived probiotics were prepared trough several processes. Genomic isolation, detection of GABA-encoding genes, and species identification using the 16S-rRNA gene encoding were performed.ResultsThe probiotics isolate used in the intervention was identified as Limosilactobacillus fermentum. We assigned this isolate as L. fermentum A2.8. The presence of the gene encoding GABA was found on this isolate. There was an increase in the cognitive domains of memory, learning process, and verbal fluency (p < 0.05) in group A (probiotics at concentration of 108 CFU/mL). Memory function, visuospatial, and verbal fluency improved (p < 0.05) in group B (probiotics at concentration of 107 CFU/mL). Only an increase in the memory domain was observed in the control group. Improvement of the learning process occurred only in group A (p = 0.006).ConclusionAdministration of probiotics derived from L. fermentum A2.8 increased the cognitive domains of memory, language and visuospatial function. However, probiotic supplementation at a concentration of 108 CFU/mL was better in improving the learning process. This study succeeded in detecting Lactic Acid Bacterial isolates L. fermentum A2.8 that enclosed gene encoding glutamate decarboxylase (gad) which is involved in the synthesis of -aminobutyric acid (GABA), a neurotransmitter vital for cognitive function.

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Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise

Chelucci,

Scarfò,

Piccarducci

et al. 2024

J Mol Neurosci

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Physical activity has been demonstrated to improve cognitive function, thereby preventing/slowing neurodegenerative diseases (NDs). Biological responses to physical activity and vulnerabilities to NDs are emerging to be gender-related. Herein, known ND-associated markers (β-amyloid, tau, α-synuclein), main sex steroid hormones, antioxidant responses, and key gene transcription modulators were evaluated in the blood of physically active and sedentary women and men. In our hands, females presented higher basal erythrocytes β-amyloid and α-synuclein amounts than males. Regular physical activity was able to significantly reduce the erythrocyte content of β-amyloid in females and the tau levels in males, suggesting that these differences may be mediated by organizational actions of sex steroid hormones during development. Furthermore, despite a comparable plasma antioxidant capability (AOC) between males and females, in the latter group, physical activity significantly enhances AOC versus peroxynitrite radicals only. Finally, regular physical activity modulated the levels of transcription factor Nrf2 in erythrocytes, as well as the plasma concentration of the microRNA miR-195 and miR-153, suggesting the promotion of antioxidant/autophagic processes associated with ND-related proteins. Overall, these results could shed light on how cerebral adaptations to physical activity differ between males and females, especially with regard to blood accumulation of ND proteins and mechanisms of antioxidant responses to regular exercise.

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Tempe, Tofu, and Amyloid-β 1–40 Serum Levels in Ovariectomized Rats

Cited by 5 publications

References 39 publications

Tempeh Consumption and Cognitive Improvement in Mild Cognitive Impairment

Tempeh Consumption and Cognitive Improvement in Mild Cognitive Impairment

Effects of Tempeh Probiotics on Elderly With Cognitive Impairment

Sex Differences in Blood Accumulation of Neurodegenerative-Related Proteins and Antioxidant Responses to Regular Physical Exercise

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