Temperature- and pH-sensitive interpenetrating polymer networks grafted on PP: Cross-linking irradiation dose as a critical variable for the performance as vancomycin-eluting systems

Muñoz‐Muñoz, Franklin; Ruíz, Juan-Carlos; Alvarez‐Lorenzo, Carmen; Concheiro, Ángel; Bucio, Emilio

doi:10.1016/j.radphyschem.2012.01.007

Cited by 34 publications

(21 citation statements)

References 34 publications

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“…Some IPN systems have been designed to switch drug release on and off as a function of temperature. Despite the abundant information about IPNs, few papers report the use of ionizing radiation for preparing smart IPNs [190][191][192]. IPNsbased on poly (NIPAAm), and poly (N-acryloxysuccinimide), PNAS, were prepared by a sequential method.…”

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

“…PNIPAAm, which was polymerized and crosslinked by gamma irradiation, was swelled in a solution of PNAS/polylysine. The phase transition or LCST of PNIPAAm was not affected with the introduction of PNAS in the structure, but compared to PNAS networks the IPN showed a fast response rate to external changes of temperature, improving their potential in field of high performance devices or systems such as rapid actuators and artificial organs [190][191][192]. …”

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

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Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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By definition, nanomaterials are multifunctional due to the co-incorporation of both therapeutic and bioimaging agents. Among the therapeutic applications of the polymeric nanomaterials are found drug, protein or gene delivery, tissue engineering. Other advances in bioapplications include cell-labeling, cell membrane modeling, agent delivery and targeting. Additionally, imaging nanobiotechnology is applied to sensorization and diagnosis with biosensors and biomarkers for biodetection and bioimaging, respectively. In this chapter are described the different polymeric nanostructures applied to therapy and diagnosis such as polymeric-based core-shell colloid, proteins and peptides, drug conjugates and complexes with synthetic polymers, dendrimers, vesicles, micelles, carbon nanotubes, biopolymers, smart nano polymers, metal-polymer complexes, enzyme-responsive nanoparticles, and hybrid polymeric nanomaterials. The different types of polymers are fabricated using several approaches ranging from conventional chemical methods to more sophisticated processes such as surface modification using ionizing radiation to obtain layers free of pollutants without purification and isolation processes among other advantages.

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Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

Section: Interpenetrating Polymer Networkmentioning

confidence: 99%

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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“…Antimicrobials, anti-inflammatory and anti-proliferative drugs, and anticoagulant agents are suitable candidates for delivery by means of medical devices for both prophylactic and therapeutic purposes (Mao et al, 2004). Once in the target site, drug release can occur by simple diffusion (Nava-Ortíz et al, 2009), in response to environmental stimuli such as temperature (Li et al, 1999) and/or pH (Muñoz-Muñoz et al, 2012), or can be triggered by the presence of microbes (Segura et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

Magaña¹,

Palomino²,

Cornejo-Bravo³

et al. 2015

Radiation Physics and Chemistry

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“…Recientemente se evaluó el efecto de la dosis y la inclusión de agente reticulante (MBAAm) sobre la síntesis de la primera red (net-PP-g-PNIPAAm), encontrándose que la irradiación a 10 kGy y en ausencia de MBAAm conduce a IPNs con una mayor respuesta inteligente y una mayor capacidad de carga y liberación de vancomicina [94]. Entre las aplicaciones que se buscan para este polímero se destaca su uso como dispositivo biomédico implantable con la capacidad de inhibir el crecimiento y la colonización bacteriana, riesgos presentes desde el momento de su inserción.…”

Section: Redes Inteligentes Interpenetradas (Ipns)unclassified

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

Muñoz‐Muñoz¹,

Contreras-García²,

Bucio³

et al.

Biomateriais Aplicados Ao Desenvolvimento De Sistemas Terapêuticos Avançados

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Temperature- and pH-sensitive interpenetrating polymer networks grafted on PP: Cross-linking irradiation dose as a critical variable for the performance as vancomycin-eluting systems

Cited by 34 publications

References 34 publications

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Radiation-grafting of acrylamide onto silicone rubber films for diclofenac delivery

Radiación gamma para el diseño de sistemas inteligentes en liberación controlada de fármacos e ingeniería de tejidos

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