Temperature-Controlled 830-nm Low-Level Laser Therapy of Experimental Pressure Ulcers

Lanzafame, Raymond J.; Stadler, István; Coleman, J.; Haerum, Belinda; Oskoui, Philip; Whittaker, Megan; Zhang, Renyu

doi:10.1089/pho.2004.22.483

Cited by 33 publications

(21 citation statements)

References 10 publications

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“…Near-infrared low-level laser therapy (LLLT) under temperature-controlled conditions have been tested for their influences on ulcer healing [140]. No evidence was found that justifies using low-level laser therapy as an adjuvant to the consensus decubitus ulcer treatment [140].…”

Section: Laser Treatmentmentioning

confidence: 99%

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Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Kuffler¹

2012

TOCVJ

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Pressure ulcers, also called decubitus ulcers, are a common challenge of humanity. They are wounds initiated by pressure on the skin that blocks circulation causing the skin and underlying tissues to die. Without care, pressure ulcers continue to grow in diameter and depth and are exceptionally difficult to heal. They have probably always existed, and are present on Egyptian mummies. Pressure ulcers are a serious health issue, very painful, a significant physiological challenge, can shorten the life of a patient, are an emotional and financial burden to the patient, those who deal with them, and in the United States alone annually costs in excess over $10 billion dollars for care and prolonged hospitalization. Pressure ulcers can develop with as little as two hours of pressure, and because even a brief lapse in avoidance of pressure leads to ulcers, they are frequently impossible to prevent, even for the most conscientious patient with an extensive support group and unlimited financial resources. Therefore, enormous effort is required to find effective and reliable techniques for preventing the initiation of ulcers and eliminating them once they develop. This review looks at the various approaches presently used and in development for the treatment of pressure ulcers, evaluates which may be best in eliminating ulcers, and discusses combinations of techniques that may be most effective in eliminating pressure ulcers.

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Section: Laser Treatmentmentioning

confidence: 99%

“…No evidence was found that justifies using low-level laser therapy as an adjuvant to the consensus decubitus ulcer treatment [140].…”

Section: Laser Treatmentmentioning

confidence: 99%

Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Kuffler¹

2012

TOCVJ

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“…• C and complete wound closure at 25 ± 6 days [12]. The results also showed that the group receiving incandescent light had a 36.3 ± 4.8% wound closure at day 14 while the group receiving laser therapy showed a significantly higher rate of wound closure at 75.4 ± 7.2% [12].…”

Section: Laser Chemistrymentioning

confidence: 78%

“…Little information is available regarding the potential thermal effects of near-infrared photoradiation during lowlevel laser therapy (LLLT) [12]. Lanzafame et al [12] studied the effect of temperature-controlled 830 nm LLLT on experimental pressure ulcers created in C57BL mice and reported that the group receiving laser therapy (830 nm 5 J/cm 2 , CW) showed a maximum temperature change during therapy of 2.0 ± 0.64…”

Section: Laser Chemistrymentioning

confidence: 99%

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Changes in Cell Viability of Wounded Fibroblasts following Laser Irradiation in Broad‐Spectrum or Infrared Light

Hawkins

Abrahamse

2006

Laser Chemistry

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Objective. This study aimed to establish if broad-spectrum or infrared (IR) light in combination with laser therapy can assist phototherapy to improve the cell function of wounded cells. Background. The effect of laser light may be partly or completely reduced by broad-spectrum light. Methods. Wounded human skin fibroblasts were irradiated with 5 J/cm 2 using a helium-neon laser, a diode laser, or an Nd:YAG laser in the dark, in the light, or in IR. Changes in cell viability were evaluated by cell morphology, ATP cell viability, LDH membrane integrity, and caspase 3/7 as an early marker of apoptosis. Results. Wounded cells exposed to 5 J/cm 2 using 632.8 nm in the dark or 830 nm in the light or 1064 nm in the dark showed an increase in ATP viability, an increase in cytokine expression, and a decrease in LDH cytotoxicity indicating that the metabolic activity of the wounded cells was stimulated. Conclusion. Wounded cells irradiated in IR light showed an undesirable thermal effect that was proportional to the duration of exposure.

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Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model

et al. 2007

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Temperature-Controlled 830-nm Low-Level Laser Therapy of Experimental Pressure Ulcers

Abstract: These results demonstrate that the salutary effects of LLLT on wound healing are temperature independent in this model.

Cited by 33 publications

References 10 publications

Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Changes in Cell Viability of Wounded Fibroblasts following Laser Irradiation in Broad‐Spectrum or Infrared Light

Reciprocity of exposure time and irradiance on energy density during photoradiation on wound healing in a murine pressure ulcer model

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