Temperature-dependent shape-responsive fluorescent nanospheres for image-guided drug delivery

Abstract

Temperature-responsive nanoparticles used in conjunction with hyperthermia promise to provide synergistic effects for increasing drug efficacy. We propose a near-infared (NIR) fluorescent system based on a upper critical solution temperature (UCST) polymer, ISP2, integrated with a NIR fluorescent dye HITC for in vivo tracking. The system forms a nanoparticle that increases its volume as temperature increases, similar to the expansion of a Hoberman sphere. The nanospheres nearly doubled in size, from 80 nm to 140 nm, during a temperature increase from 40°C to 60°C

Novel Eye Drop Delivery Systems: Advance on Formulation Design Strategies Targeting Anterior and Posterior Segments of the Eye

“…The transition occurs at either the lower critical solution temperature (LCST) or the upper critical solution temperature (UCST), depending on the type of polymer used. There are three common types of temperaturesensitive gels, namely positive temperature-sensitive gels [77], negative temperaturesensitive gels, and thermally reversible gels [78]. Positive temperature-sensitive gels undergo a transition below UCST.…”

Ratiometric Afterglow Nanothermometer for Simultaneous in Situ Bioimaging and Local Tissue Temperature Sensing

“…To overcome the aforementioned drawback, a NIR light reexcitation strategy was performed when the NIR afterglow intensity of the ZGGO:Cr 3+ RANTH was undetectable after a long-term detection. Here, an 808 nm laser was used as a reexcitation source because of its high level of penetration as reported by He et al 51 The photostimulatable luminescence spectrum of the ZGGO:Cr 3+ RANTH covered by a 3 mm thick pork tissue under 808 nm excitation (200 mW/cm 2 ) with a 30 min delay time after stopping UV irradiation is shown in Figure 10a. It can be found that the intense NIR emission intensity (λ em = 696 nm) can be acquired when the 808 nm laser is on (duration time, 30 s).…”

Colloidal (Gd0.98Nd0.02)2O3 nanothermometers operating in a cell culture medium within the first and second biological windows

“…In the last five years, significant progress has been made in the development of biocompatible, efficient and accurate nanoprobes for applications in nanomedicine and nanotechnology, [1][2][3][4] such as intracellular temperature sensing, 5 in vivo/in vitro imaging, 6 clinical diagnosis, 7 drug delivery, 8 and cancer therapy. 9 The widely employed probing materials include quantum dots, 10 carbon nanomaterials, 11 plasmonic nanostructures, 12 nanodiamonds, 13 polymeric nanoparticles, 14 and luminescent nanocrystals.…”