Temperature-dependent stability and DPPH scavenging activity of liposomal curcumin at pH 7.0

Niu, Yumeng; Ke, Dan; Yang, Qianqian; Wang, Xiaoyong; Chen, Zhiyun; An, Xueqin; Shen, Weiguo

doi:10.1016/j.foodchem.2012.06.018

Cited by 70 publications

(43 citation statements)

References 31 publications

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“…When DPPH encounters a proton-donating substance, such as an antioxidant, the radical is scavenged and the absorbance of DPPH is reduced [43]. Fig.…”

Section: Dpph Scavenging Activity Of Quercetinmentioning

confidence: 99%

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Zhou

Wang

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…When DPPH encounters a proton-donating substance, such as an antioxidant, the radical is scavenged and the absorbance of DPPH is reduced [43]. Fig.…”

Section: Dpph Scavenging Activity Of Quercetinmentioning

confidence: 99%

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Zhou

Wang

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…16 Liposomes can transport both hydrophilic and hydrophobic components by entrapping them in the inner aqueous phase and incorporating them into the lipid bilayers, respectively. 17 Curcumin-loaded liposomes (CLs) have been prepared mainly by the thin lm method 15,[18][19][20][21][22] or the ethanol injection method, 17 and the properties and stability of these CLs have been widely studied by a number of groups. Our group has also investigated CLs prepared by the thin lm method 14,23 and ethanol injection method.…”

Section: Introductionmentioning

confidence: 99%

Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process

et al. 2017

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“…The ability of the compounds to bleach 1,1-Diphenyl-2-picryl-hydrazyl (DPPH) [13] can be quantified using a spectrophotometric assay. …”

Section: Dpph Scavenging Activitymentioning

confidence: 99%

Targeting biofilm inhibition using Quercetin – Interaction with bacterial cell membrane and ROS mediated biofilm control

Sarangapani¹,

Jayachitra²

2018

FFHD

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Citation: Sreelatha S., Jayachitra A., Targeting biofilm inhibition using Quercetin -Interaction with bacterial cell membrane and ROS mediated biofilm control. Functional Foods in Health and Disease 2018; 8(6): 292-306 ABSTRACT Background: Quercetin is an active nutraceutical ingredient widely distributed in foods, vegetables, fruits, and more. Quercetin is a versatile functional food with extensive protective effects against many infectious and degenerative diseases due to their antioxidant activities. Apsergillus niger is a filamentous fungus and the most abundant mold found in the environment. This fungus has been the source of several bioactive compounds and industrial enzymes through biotransformation. Aim:In this report we emphasized the potential of Aspergillus species for the selective conversion of rutin to quercetin, which involved stereoselective and regiospecific reactions with enhanced production and minimization of the formation of toxic wastes. This fungal microbe was able to transform the complex structure of rutin to quercetin with remarkable catalytic activity for the reaction with high product yield. The quercetin produced demonstrated the ability to inhibit biofilm formation and eradicate established biofilm involving the production of reactive oxygen species (ROS) indicative of membrane activity. These results suggest quercetin may have implications in biofilm control targeting reactive oxygen species as a novel therapeutic strategy. Methods: Quercetin was synthesized by microbial biotransformation recruiting Aspergillus niger.The synthesis of quercetin was compared with the chemical process. Furthermore, the quercetin produced by the biotransformation process was characterized by high performance thin layer liquid chromatography. The quercetin produced was assessed for biological activities. The antimicrobial activity, hemolytic activity, inhibition of biofilm by crystal violet staining, and cell viability by confocal laser scanning microscope was assessed. The membrane interaction effect and oxidant scavenging effect by DPPH, Intracellular ROS release, and lipid peroxidation was measured. Results:Quercetin produced by microbial transformation demonstrated antimicrobial activity against S. aureus by effectively inhibiting the growth and dispersion of preformed biofilms. Quercetin demonstrated a significant free radical scavenging activity and significant inhibition of lipid peroxidation. Significant release of reactive oxygen species was observed in bacterial cells.

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Temperature-dependent stability and DPPH scavenging activity of liposomal curcumin at pH 7.0

Cited by 70 publications

References 31 publications

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Spectrometric study on the interaction of sodium cholate aggregates with quercetin

Improved bioavailability of curcumin in liposomes prepared using a pH-driven, organic solvent-free, easily scalable process

Targeting biofilm inhibition using Quercetin – Interaction with bacterial cell membrane and ROS mediated biofilm control

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