For now, the open humidification method is applied in the tobacco bulk curing barn, which has some disadvantages, such as the loss of the oil content and aroma components of the tobacco leaves and the waste heat loss of the exhaust air flow. In this context, a tobacco bulk curing barn with totally closed hot air circulation is designed to perfect the curing quality of tobacco and avoid the loss of residual heat in the bulk curing barn. Meanwhile, due to the balance and symmetry of input and output of the curing barn temperature, according to the law of conservation of energy, a mathematical model of the temperature control system of the closed hot air circulation tobacco bulk curing barn is established, and the temperature transfer function of the system is obtained. On this basis, 10 algorithms are used to optimize the full closed hot air circulation tobacco bulk curing barn temperature control system PID parameters. The result of the sobol sequence seeker optimization algorithm (SSOA) is better than the other algorithms. So, the PID control strategy based on the SSOA is used to simulate and experiment the temperature control system of tobacco bulk curing barn. The simulation and experimental results show that for the tobacco bulk curing barn temperature control system, the sobol sequence seeker optimization algorithm PID control has better dynamic characteristics compared with fuzzy PID control, and the temperature control system of tobacco bulk curing barn has fast adjustment and small overshoot. Therefore, the new baking barn with proper PID parameters can improve the tobacco’s curing quality and save energy by reducing the residual heat.