Temperature Distribution in the Human Brain During Ultrasound Hyperthermia

Ismail, Nour Eldin; Ibrahim, Ashraf T.

doi:10.1163/156939302x00165

Cited by 7 publications

(6 citation statements)

References 6 publications

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“…In order to address the challenge of noninvasive transcranial delivery of US energy inside human skull various studies have been performed. It includes noninvasive approach in, 32 ex vivo heterogeneous medium optimization in, 33 amplitude and phase correction in, 34 phased array in, 35 cylindrical array applicator in, 36 and time reversal methods in, [37][38][39] in vivo phase aberration correction techniques in, 38,40 and image guided therapeutic approaches in. [41][42][43] To investigate the propagation of acoustic energy inside head phantom, we excite one of the transducers (near to tumor) with frequencies 0.05, 0.5, 1, and 2 MHz and observe the insonation intensity (in Pascal) inside the phantom as shown in Figure 5A-D.…”

Section: Us M Odelmentioning

confidence: 99%

Efficient energy localization for hybrid wideband hyperthermia treatment system

Nizam-Uddin

Elshafiey

2018

Int J RF Microw Comput Aided Eng

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This article presents efficient energy localization approach for hybrid wideband system for hyperthermia treatment of cancer based on a transmission line (TL). A heterogeneous head phantom is built by incorporating frequency dependent tissue properties of head layers considering both electromagnetic and ultrasound treatment. Effective medium properties are derived and used to compensate signal phase and magnitude values based on TL model. The obtained field map results emphasize the feasibility of the developed approach to obtain system parameters that enhance energy localization and eradicate hotspots.

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Section: Us M Odelmentioning

confidence: 99%

Efficient energy localization for hybrid wideband hyperthermia treatment system

Nizam-Uddin

Elshafiey

2018

Int J RF Microw Comput Aided Eng

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“…After SAR has been calculated and recorded, it is utilized as the source term in the transient bioheat equation [3,5,13,14,24],…”

Section: Thermal Simulationsmentioning

confidence: 99%

Assessment of Human Head Exposure to Wireless Communication Devices: Combined Electromagnetic and Thermal Studies for Diverse Frequency Bands

Zygiridis¹,

Tsiboukis²

2008

PIER B

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Abstract-In this paper, an integrated and manifold study of the combined electromagnetic and thermal effects, caused by human exposure to microwave radiation is carried out. In essence, we numerically calculate the amount of electromagnetic power absorbed by biological tissues for various exposure conditions and types of emitting sources, utilizing a detailed model of the human head. The severity of the obtained results is evaluated via comparisons with the guidelines of international safety standards, while further insight is gained by investigating the induced thermal effects. The latter are properly quantified through the solution of the bioheat equation, when combined with the outcome of the electromagnetic simulations. Spatial distributions of the corresponding temperature changes are thus calculated, their relation to the dissipated power is established, and the thermal response of human tissues in marginal cases of exposure is predicted.

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“…Various studies have been performed to investigate the feasibility of focusing ultrasound energy inside the human skull. These include a noninvasive approach in [ 31 ], ex vivo heterogeneous medium optimization in [ 32 ], amplitude and phase correction in [ 33 ], phased array in [ 34 ], cylindrical array applicator in [ 35 ], and time reversal methods in [ 36 – 38 ]. Other advanced techniques depend on in vivo phase aberration correction techniques in [ 37 , 39 ], along with image guided therapeutic approaches [ 40 – 42 ].…”

Section: Introductionmentioning

confidence: 99%

Enhanced Energy Localization in Hyperthermia Treatment Based on Hybrid Electromagnetic and Ultrasonic System: Proof of Concept with Numerical Simulations

Nizam-Uddin

Elshafiey

2017

BioMed Research International

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This paper proposes a hybrid hyperthermia treatment system, utilizing two noninvasive modalities for treating brain tumors. The proposed system depends on focusing electromagnetic (EM) and ultrasound (US) energies. The EM hyperthermia subsystem enhances energy localization by incorporating a multichannel wideband setting and coherent-phased-array technique. A genetic algorithm based optimization tool is developed to enhance the specific absorption rate (SAR) distribution by reducing hotspots and maximizing energy deposition at tumor regions. The treatment performance is also enhanced by augmenting an ultrasonic subsystem to allow focused energy deposition into deep tumors. The therapeutic faculty of ultrasonic energy is assessed by examining the control of mechanical alignment of transducer array elements. A time reversal (TR) approach is then investigated to address challenges in energy focus in both subsystems. Simulation results of the synergetic effect of both modalities assuming a simplified model of human head phantom demonstrate the feasibility of the proposed hybrid technique as a noninvasive tool for thermal treatment of brain tumors.

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Temperature Distribution in the Human Brain During Ultrasound Hyperthermia

Cited by 7 publications

References 6 publications

Efficient energy localization for hybrid wideband hyperthermia treatment system

Efficient energy localization for hybrid wideband hyperthermia treatment system

Assessment of Human Head Exposure to Wireless Communication Devices: Combined Electromagnetic and Thermal Studies for Diverse Frequency Bands

Enhanced Energy Localization in Hyperthermia Treatment Based on Hybrid Electromagnetic and Ultrasonic System: Proof of Concept with Numerical Simulations

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