Proton exchange membrane fuel cell (PEMFC) is thermochemical-electrical device for clean energy utilization as a practical renewable energy resource. Among several types of fuel cells PEMFC has compact size, wide applications, integrated structure and controlled operation conditions for realistic performance. PEMFC operates within temperature range of (25-80 o C) and slightly above, which need special cooling system to maintain harmless thermal operation of the cell. In this simulation study a functional cooling system for PEMFC is proposed, designed and investigated for best PEMFC performance and efficiency. This system is examined for energetic outcome of PEMFC using different materials, geometry, working fluids, operating conditions, and thermal properties of cooling fluids. The results reveals that greatest efficiency of cooling system of PEMFC is associated to higher flow rate and thermal properties of cooling fluid like specific heat (C p ) and convection heat transfer coefficient (h), in addition to thermal emissivity (ε), thermal conductivity (k). Furthermore, the best cooling system efficiency range was 60% to 80% when Argon was used, and 40% to 55% for water, while the least range was 17% to 22% when air was used as a cooling medium.