Temperature effect on contractile activity of the Ambystoma dumerilii heart previously treated with isoproterenol

Cano-Martı́nez, Agustina; Vargas-González, Álvaro; Guarner-Lans, Verónica

doi:10.1016/j.cbpa.2006.10.030

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…High doses of isoproterenol overstimulate the heart and induce cardiac hypertrophy, cardiomyocyte death and fibrosis. 43 , 44 A. dumerilii is able to gradually recover cardiac function from days 5–90 after this pharmacological intervention. However, an analysis of cardiomyocyte proliferation and myocardial regeneration in this injury model has not been undertaken.…”

Section: Heart Regeneration In Non-mammalian Vertebratesmentioning

confidence: 97%

“…However, an analysis of cardiomyocyte proliferation and myocardial regeneration in this injury model has not been undertaken. 43 In contrast, cryoinjury and resection injury induce a more well-defined structural damage to the myocardium. Following cryoinjury or ventricular resection, A. mexicanum has the ability to structurally and functionally regenerate within 60–90 days.…”

Section: Heart Regeneration In Non-mammalian Vertebratesmentioning

confidence: 99%

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Evolution, comparative biology and ontogeny of vertebrate heart regeneration

2016

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There are 64,000 living species of vertebrates on our planet and all of them have a heart. Comparative analyses devoted to understanding the regenerative potential of the myocardium have been performed in a dozen vertebrate species with the aim of developing regenerative therapies for human heart disease. Based on this relatively small selection of animal models, important insights into the evolutionary conservation of regenerative mechanisms have been gained. In this review, we survey cardiac regeneration studies in diverse species to provide an evolutionary context for the lack of regenerative capacity in the adult mammalian heart. Our analyses highlight the importance of cardiac adaptations that have occurred over hundreds of millions of years during the transition from aquatic to terrestrial life, as well as during the transition from the womb to an oxygen-rich environment at birth. We also discuss the evolution and ontogeny of cardiac morphological, physiological and metabolic adaptations in the context of heart regeneration. Taken together, our findings suggest that cardiac regenerative potential correlates with a low-metabolic state, the inability to regulate body temperature, low heart pressure, hypoxia, immature cardiomyocyte structure and an immature immune system. A more complete understanding of the evolutionary context and developmental mechanisms governing cardiac regenerative capacity would provide stronger scientific foundations for the translation of cardiac regeneration therapies into the clinic.

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Section: Heart Regeneration In Non-mammalian Vertebratesmentioning

confidence: 97%

Section: Heart Regeneration In Non-mammalian Vertebratesmentioning

confidence: 99%

Evolution, comparative biology and ontogeny of vertebrate heart regeneration

2016

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“…Evidence clearly points to a link between metabolism and cardiac performance in adult vertebrates, and this link represents the main driver for adaptions and adjustments of cardiac activity in response to changing environmental conditions. However, it is unclear whether this relationship exists in embryonic and early larval stages of ectothermic vertebrates, in which the circulatory system does not initially play a primary role in oxygen delivery (Burggren, 2005, 2013; Cano-Martínez et al, 2007; Mirkovic and Rombough, 1998; Pelster and Burggren, 1996). In the natural environment, these physiological and morphological changes are influenced by temperature changes, which may cause significant fluctuations in productivity and distribution of fish populations, therefore leading to important ecological and evolutionary consequences (Pörtner, 2001; Pörtner et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Morphology and cardiac physiology are differentially affected by temperature in developing larvae of the marine fish mahi-mahi (Coryphaena hippurus)

et al. 2017

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Cardiovascular performance is altered by temperature in larval fishes, but how acute versus chronic temperature exposures independently affect cardiac morphology and physiology in the growing larva is poorly understood. Consequently, we investigated the influence of water temperature on cardiac plasticity in developing mahi-mahi. Morphological (e.g. standard length, heart angle) and physiological cardiac variables (e.g. heart rate fH, stroke volume, cardiac output) were recorded under two conditions by imaging: (i) under acute temperature exposure where embryos were reared at 25°C up to 128 h post-fertilization (hpf) and then acutely exposed to 25 (rearing temperature), 27 and 30°C; and (ii) at two rearing (chronic) temperatures of 26 and 30°C and performed at 32 and 56 hpf. Chronic elevated temperature improved developmental time in mahi-mahi. Heart rates were 1.2–1.4-fold higher under exposure of elevated acute temperatures across development (Q10≥2.0). Q10 for heart rate in acute exposure was 1.8-fold higher compared to chronic exposure at 56 hpf. At same stage, stroke volume was temperature independent (Q10∼1.0). However, larvae displayed higher stroke volume later in stage. Cardiac output in developing mahi-mahi is mainly dictated by chronotropic rather than inotropic modulation, is differentially affected by temperature during development and is not linked to metabolic changes.

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Isoprenaline Impairs Contractile Function of Ventricular Myocardium in Common Frog (Rana temporaria)

Kibler¹,

Nuzhny²,

Shmakov³

2018

Bull Exp Biol Med

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The contractile function of the heart was studied in adult frogs Rana temporaria under the influence of a toxic dose of isoprenaline under conditions of natural sinoatrial rhythm and during heart pacing. The dynamics of ventricular pressure was recorded with a Prucka MacLab 2000 instrument via a catheter introduced into the ventricle through the ventricular wall. Reduced (p<0.05) parameters of the pump function (HR, maximum ventricular systolic pressure, isovolumic indices dP/dt and dP/dt) and lengthening of QRS complex and QT interval on ECG attested to impairment of contractile function and electrical processes after exposure to isoprenaline. Electrical stimulation of the right atrium improved myocardial contractility and ECG parameters after the administration of isoprenaline.

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Temperature effect on contractile activity of the Ambystoma dumerilii heart previously treated with isoproterenol

Cited by 4 publications

References 37 publications

Evolution, comparative biology and ontogeny of vertebrate heart regeneration

Evolution, comparative biology and ontogeny of vertebrate heart regeneration

Morphology and cardiac physiology are differentially affected by temperature in developing larvae of the marine fish mahi-mahi (Coryphaena hippurus)

Isoprenaline Impairs Contractile Function of Ventricular Myocardium in Common Frog (Rana temporaria)

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