Temperature Management and Health-Related Quality of Life in Children 3 Years After Cardiac Arrest

Magee, Aidan; Deschamps, Rachel; Delzoppo, Carmel; Pan, Kevin C; Butt, Warwick; Dagan, M.; Forrest, Anri; Namachivayam, Siva P.

doi:10.1097/pcc.0000000000002821

Cited by 5 publications

(9 citation statements)

References 23 publications

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“…Magee A, Deschamps R, Delzoppo C, et al: Temperature Management and Health-Related Quality of Life in Children 3 Years After Cardiac Arrest (1).…”

Section: What Hrqol Outcomes After Out-of-hospital Cardiac Arrest Are...mentioning

confidence: 99%

Editor’s Choice Articles for January

Tasker¹

2022

Pediatric Critical Care Medicine

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W elcome to January 2022 and volume 23 of Pediatric Critical Care Medicine (PCCM). All of our articles are topical and interesting, and it is a privilege to see such good and informed writing. That said, I must draw your attention to only three Editor's Choices articles: temperature management and health-related quality of life (HRQoL) 3-years after cardiac arrest (1); a PCCM Special Article on standardized training for physicians practicing pediatric cardiac critical care medicine (PCCCM) (2); and, the executive summary from the Transfusion and Anemia Expertise Initiative-Control/Avoidance of Bleeding (TAXI-CAB) collaborative reporting their consensus for plasma and platelet transfusion in critically ill children (3). All three of these open reports have additional supporting articles (4-12).

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“…Magee A, Deschamps R, Delzoppo C, et al: Temperature Management and Health-Related Quality of Life in Children 3 Years After Cardiac Arrest (1).…”

Section: What Hrqol Outcomes After Out-of-hospital Cardiac Arrest Are...mentioning

confidence: 99%

Editor’s Choice Articles for January

Tasker¹

2022

Pediatric Critical Care Medicine

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“…but did not receive an answer. After review, 14 studies [10,11,[13][14][15][16][17][18][19][20][21][22][23][24] were included in the qualitative analysis and 7 studies [10,11,[13][14][15][16][17] in the quantitative synthesis (NMA). The reasons for not including 7 studies [18][19][20][21][22][23][24] in the quantitative analysis are given in Table 2.…”

Section: Study Selectionmentioning

confidence: 99%

“…After review, 14 studies [ 10 , 11 , 13 - 24 ] were included in the qualitative analysis and 7 studies [ 10 , 11 , 13 - 17 ] in the quantitative synthesis (NMA). The reasons for not including 7 studies [ 18 - 24 ] in the quantitative analysis are given in Table 2 .…”

Section: Reviewmentioning

confidence: 99%

“…A systematic review/meta-analysis published in 2019 did not find any results that supported or rejected the use of hypothermia [12]. Although the duration of therapeutic hypothermia is considered important, previous studies have shown that therapeutic hypothermia is conducted for various durations, including 24 h, 48 h, and 72 h [10,11,[13][14][15][16][17][18][19][20][21][22][23][24]. While current guidelines recommend TTM, there is no mention of the appropriate temperature or length of the treatment [7,8].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Target Temperature Management Following Pediatric Cardiac Arrest: A Systematic Review and Network Meta-Analysis to Compare the Effectiveness of the Length of Therapeutic Hypothermia

Amagasa¹,

Yasuda²,

Oishi³

et al. 2022

Cureus

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We aimed to compare the efficacy of therapeutic hypothermia for 24, 48, and 72 h, and normothermia following pediatric cardiac arrest. We searched the Cochrane Central Register of Controlled Trials, MEDLINE via Ovid, World Health Organization International Clinical Trials Platform Search Portal, and ClinicalTrials.gov. from their inception to December 2021. We included randomized controlled trials and observational studies evaluating target temperature management (TTM) in children aged < 18 years with the return of spontaneous circulation (ROSC) after cardiac arrest. We compared four intervention groups (normothermia, therapeutic hypothermia for 24 h (TTM 24h), therapeutic hypothermia for 48 h (TTM 48h), and therapeutic hypothermia for 72 h (TTM 72h)) using network meta-analysis. The outcomes were survival and favorable neurological outcome at 6 months or more. Seven studies involving 1008 patients and four studies involving 684 patients were included in the quantitative synthesis of survival and neurological outcome, respectively. TTM for 72 h was associated with a higher survival rate, compared to normothermia (RR 1.75 (95% CI 1.27-2.40)) (very low certainty), TTM 24h (RR 1.53 (95% CI 1.06-2.19)) (low certainty), and TTM 48h (RR 1.54 (95% CI 1.06-2.22)) (very low certainty). TTM for 72 h was also associated with favorable neurological outcomes compared with normothermia (RR 9.36 (95% CI 2.04-42.91)), or TTM 48h )) (all very low certainty). TTM for 24 h was associated with favorable neurological outcome, compared with normothermia (RR 8.02 (95% CI 1.28-50.50)) (very low certainty). In the ranking analysis, the hierarchies for efficacy for survival and favorable neurological outcome were TTM 72h > TTM 48h > TTM 24h > normothermia. Although prolonged therapeutic hypothermia might be effective in pediatric patients with ROSC after cardiac arrest, the evidence to support this result is only weak to very weak. There is no conclusive evidence regarding the effectiveness and length of therapeutic hypothermia and high-quality RCRs comparing long-length therapeutic hypothermia to short-length hypothermia and normothermia are needed.

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“…Although physical summary scores were also lower than population norms in the TH group, psychosocial summary scores were not different. Magee et al (11) contend that children who receive TH may be close to the normal population, whereas children who did not receive TH have poorer outcomes than their peers. Their results suggest that the therapeutic effects of hypothermia may extend beyond hospital discharge.…”

mentioning

confidence: 99%