Temperature regulation and anesthesia

Chinyanga, H. M.

doi:10.1016/0163-7258(84)90014-7

Cited by 4 publications

(1 citation statement)

References 66 publications

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“…Heat loss occurs by four mechanisms: radiation, convection, conduction, and evaporation. For a nude adult in a room at ambient temperature, heat losses from radiation, convection, conduction, and evaporation are approximately 60%, 12%, 3%, and 25%, respectively (78). With the loss of the dry protective skin barrier, evaporative losses become more significant.…”

Section: Anesthetic Considerations For Acute Burn Proceduresmentioning

confidence: 99%

Anesthetic considerations for major burn injury in pediatric patients

Fuzaylov

Fidkowski

2009

Pediatric Anesthesia

118

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Major burn injury remains a significant cause of morbidity and mortality in pediatric patients. With advances in burn care and with the development of experienced multi-disciplinary teams at regionalized burn centers, many children are surviving severe burn injury. As members of the multi-disciplinary care team, anesthesia providers are called upon to care for these critically ill children. These children provide several anesthetic challenges, such as difficult airways, difficult vascular access, fluid and electrolyte imbalances, altered temperature regulation, sepsis, cardiovascular instability, and increased requirements of muscle relaxants and opioids. The anesthesia provider must understand the physiologic derangements that occur with severe burn injury as well as the subsequent anesthetic implications.

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Section: Anesthetic Considerations For Acute Burn Proceduresmentioning

confidence: 99%

Anesthetic considerations for major burn injury in pediatric patients

Fuzaylov

Fidkowski

2009

Pediatric Anesthesia

118

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Influence of Hypo and Hyperthermia on Disposition of Morphine

Bansinath

Turndorf

Puig

1988

The Journal of Clinical Pharma

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Using morphine as a prototype opiate anesthetic, the dispositional changes and cardiovascular effects during hypothermia (30 degrees C) and hyperthermia (40 degrees C) in dogs under isoflurane anesthesia was assessed. Single intravenous bolus injection of 1 mg/kg morphine resulted in a significant and sustained decrease in mean arterial pressure in hypothermic, but not in hyperthermic or normothermic (37 degrees C) conditions. Hypothermic dogs showed significantly higher levels of morphine both in plasma and in cerebrospinal fluid. In contrast, hyperthermia did not affect these levels. Body temperature did not affect the t1/2 alpha, however t1/2 beta and mean residence time were significantly increased while volume of distribution at steady state and total body clearance were decreased during hypothermia. The results provide evidence that hypothermia is likely to be associated with a sustained increase in opiate levels and might be associated with a enhanced side effects. The results suggests the need for a controlled clinical trial to assess the dose of opiate anesthetics during hypothermia.

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Functional mechanisms of temperature regulation, adaptation and fever: Complementary system theoretical and experimental evidence

Werner

1988

Pharmacology & Therapeutics

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Temperature regulation and anesthesia

Cited by 4 publications

References 66 publications

Anesthetic considerations for major burn injury in pediatric patients

Anesthetic considerations for major burn injury in pediatric patients

Influence of Hypo and Hyperthermia on Disposition of Morphine

Functional mechanisms of temperature regulation, adaptation and fever: Complementary system theoretical and experimental evidence

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