Temperature-responsive poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) nanogels for controlled release studies of curcumin

Abstract

(2015) Temperature-responsive poly(N-vinylcaprolactam-co-hydroxyethyl methacrylate) nanogels for controlled release studies of curcumin, Designed Monomers and Polymers, 18:8, 705-713, DOI: 10.1080/15685551.2015 A series of nanogels (NGs) were developed from N-vinylcaprolactam and hydroxyethyl methacrylate through free radical emulsion polymerization using methylene bis acrylamide as cross-linker. Curcumin, an anticancer agent was successfully loaded into these NGs via equilibrium in situ method. These NGs were characterized by Fourier transform spectroscopy (FTIR), differential scanning calorimetry (DSC), transmission electron microscopy (TEM), and dynamic light-scattering experimental (DLS) techniques. The formation of co-polymeric NGs was confirmed by FTIR analysis. DSC results reveal that the drug was molecularly dispersed in the NG networks. TEM results indicate the formation of NGs, in a spherical shape, with the size of 150 nm. The DLS results also support the formation and size of NGs. An in vitro release study indicates that the NGs may be potentially useful for targeted drug delivery applications.

Stimuli Responsive Poly(Vinyl Caprolactam) Gels for Biomedical Applications

“…From in vitro release, the nanogels showed pH and thermoresponsive behavior (Figure 4). Sudhakar et al used the same emulsion polymerization for the incorporation of hydrophilic 2-hydroxyethyl methacrylate (HEMA) chains into PNVCL nanogels and produced a spherical shape, 150 nm in size [86]. In this study, a hydrophobic curcumin (CUR) model drug was encapsulated successfully during the polymerization process.…”

<p>Review of Curcumin Physicochemical Targeting Delivery System</p>

“…At 25°C (below LCST), the release of CUR from gels increased (about 88%), but at 37°C (above LCST) the cumulative release decreased (about 70%). 117 Therefore, the topical administration of nanogels are potentially useful for targeted drug delivery.…”

Micro and Nanogels for Biomedical Applications

“…Thermosensitive micro and nanogels are another type of versatile particles widely employed in stimuli responsive drug release applications [113][114][115][116]. Temperature sensitivity can be steadily imparted through micro and nanogels with various temperature responsive polymers that are included during particle synthesis are p(NIPAM) and poly(N-vinyl caprolactam) (p(NVCL)) as the most commonly used thermosensitive polymers [116,117]. For example, lower critical solution temperature (LCST) of p(NIPAM) lies approximately at 32°C, below this temperature p(NIPAM) polymers are well hydrated in water via hydrogen bonding due to increased hydrophilicity of polymers whereas above LCST, the hydrophobicity of the polymer increases further where the polymer undergoes a volume phase transition and shrinks because of the decreased polymer-solvent interactions (i.e.…”