Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors

Akimoto, Jun; Nakayama, Masamichi; Okano, Teruo

doi:10.1016/j.jconrel.2014.06.062

Cited by 181 publications

(94 citation statements)

References 75 publications

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“…1 Various nanomaterials have been used in drug delivery research fields as they can effectively deliver drugs to target sites and thus increase the therapeutic benefit while minimizing the side effects. [3][4][5] Among these stimuli, pH response has been widely employed in designing novel smart nanomaterials for drug delivery and disease therapy. [3][4][5] Among these stimuli, pH response has been widely employed in designing novel smart nanomaterials for drug delivery and disease therapy.…”

mentioning

confidence: 99%

High quality β-FeOOH nanostructures constructed by a biomolecule-assisted hydrothermal approach and their pH-responsive drug delivery behaviors

et al. 2015

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mentioning

confidence: 99%

High quality β-FeOOH nanostructures constructed by a biomolecule-assisted hydrothermal approach and their pH-responsive drug delivery behaviors

et al. 2015

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“…97 Physically entrapped and covalently bonded micelles drug conjugate play an important role in controlled drug release system. 98 Drug loading to micelles generally depends on upon the physiochemical property of drug, the chemical composition of core forming polymers, and physical state of micelles core. 99 The release is generally affected by temperature, pH, and environment.…”

Section: Micellesmentioning

confidence: 99%

Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Soni¹,

Ruhela²,

Medhi³

2016

Adv Pharm Bull

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“…To avoid its side effects and improve the therapeutic outcome, various delivery systems that are responsive to different stimuli (e.g., pH, redox environment, magnetic field, heat and light, electric field) have been developed to enable effective control over the delivery of cancer therapeutic payloads (drugs and biomolecules) [113, 150–152]. Among all the above stimuli, light activated delivery systems allow temporal and spatial control over the delivery process.…”

Section: Applications Of Upconversion-based Photoactivated Cancer Tmentioning

confidence: 99%

Near-infrared light activated delivery platform for cancer therapy

Lin

Gao

Hornicek

et al. 2015

Advances in Colloid and Interface Science

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Cancer treatment using conventional drug delivery platforms may lead to fatal damage to normal cells. Among various intelligent delivery platforms, photoresponsive delivery platforms are becoming popular, as light can be easily focused and tuned in terms of power intensity, wavelength, and irradiation time, allowing remote and precise control over therapeutic payload release both spatially and temporally. This unprecedented controlled delivery manner is important to improve therapeutic efficacy while minimizing side effects. However, most of the existing photoactive delivery platforms require UV/visible excitation to initiate their function, which involves the issues of phototoxicity and low level of tissue penetration limiting their practical applications in biomedicine. With the advanced optical property of converting near infrared (NIR) excitation to localized UV/visible emission, upconversion nanoparticles (UCNPs) have emerged as a promising photoactive delivery platform that provides practical applications for remote spatially and temporally controlled release of therapeutic payload molecules using low phototoxic and high tissue penetration NIR light as the excitation source. This article reviews the state-of-the-art design, synthesis and therapeutic molecular payload encapsulation strategies of UCNP-based photoactive delivery platforms for cancer therapy. Challenges and promises for engineering of advanced delivery platforms are also highlighted.

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Temperature-responsive polymeric micelles for optimizing drug targeting to solid tumors

Cited by 181 publications

References 75 publications

High quality β-FeOOH nanostructures constructed by a biomolecule-assisted hydrothermal approach and their pH-responsive drug delivery behaviors

High quality β-FeOOH nanostructures constructed by a biomolecule-assisted hydrothermal approach and their pH-responsive drug delivery behaviors

Nanomedicine in Central Nervous System (CNS) Disorders: A Present and Future Prospective

Near-infrared light activated delivery platform for cancer therapy

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