Temperature‐responsiveness and sustained delivery properties of macroporous PEG‐<i>co</i>‐PNIPAAm‐<i>co</i>‐PCL hydrogels

Li, Zhao Xia; Lu, Maoping; Wu, Kun; Zhang, Yun Fei; Miao, Lei; Li, Yin Wen; Guo, Hui; Zheng, Jian

doi:10.1002/pen.23877

Cited by 6 publications

(5 citation statements)

References 43 publications

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“…Li et al., proposed the use of poly(ethylene glycol) (PEG)-PNIPAAm-poly(e-caprolactone) (PCL) hydrogels with LCST around 31 °C as potential systems for long-term drug delivery. 27 In addition, PCL-PNIPAAm amphiphilic graft copolymers were also synthesized for the same drug delivery application. 28 …”

Section: Results and Discussionmentioning

confidence: 99%

“…Due to its thermal gelling properties allowing minimally invasive applications, PNIPAAm has gained significant interest for injectable materials in drug and cell delivery systems. Li et al., proposed the use of poly(ethylene glycol) (PEG)-PNIPAAm-poly(e-caprolactone) (PCL) hydrogels with LCST around 31 °C as potential systems for long-term drug delivery . In addition, PCL-PNIPAAm amphiphilic graft copolymers were also synthesized for the same drug delivery application …”

Section: Results and Discussionmentioning

confidence: 99%

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Biomimetic Polymers for Cardiac Tissue Engineering

et al. 2016

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Heart failure is a morbid disorder characterized by progressive cardiomyocyte (CM) dysfunction and death. Interest in cell-based therapies is growing, but sustainability of injected CMs remains a challenge. To mitigate this, we developed an injectable biomimetic Reverse Thermal Gel (RTG) specifically engineered to support long-term CM survival. This RTG biopolymer provided a solution-based delivery vehicle of CMs, which transitioned to a gel-based matrix shortly after reaching body temperature. In this study we tested the suitability of this biopolymer to sustain CM viability. The RTG was biomolecule-functionalized with poly-l-lysine or laminin. Neonatal rat ventricular myocytes (NRVM) and adult rat ventricular myocytes (ARVM) were cultured in plain-RTG and biomolecule-functionalized-RTG both under 3-dimensional (3D) conditions. Traditional 2D biomolecule-coated dishes were used as controls. We found that the RTG-lysine stimulated NRVM to spread and form heart-like functional syncytia. Regarding cell contraction, in both RTG and RTG-lysine, beating cells were recorded after 21 days. Additionally, more than 50% (p value < 0.05; n = 5) viable ARVMs, characterized by a well-defined cardiac phenotype represented by sarcomeric cross-striations, were found in the RTG-laminin after 8 days. These results exhibit the tremendous potential of a minimally invasive CM transplantation through our designed RTG-cell therapy platform.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Biomimetic Polymers for Cardiac Tissue Engineering

et al. 2016

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“…PNIPAM is a thermo‐responsive polymer, its volume phase transition temperature is slightly higher than room temperature. This polymer is hydrophilic when the temperature is below the lower critical solution temperature (about 32°C) 29 . Upon heating, PNIPAM becomes hydrophobic‐contractive chains and precipitates from the solution 30 .…”

Section: Introductionmentioning

confidence: 99%

“…This polymer is hydrophilic when the temperature is below the lower critical solution temperature (about 32 C). 29 Upon heating, PNIPAM becomes hydrophobic-contractive chains and precipitates from the solution. 30 If PDMAEMA and PNIPAM are introduced into the membranes simultaneously, it is possible to prepare polymeric membranes with both pH and thermal response.…”

Section: Introductionmentioning

confidence: 99%

One‐pot three‐step synthesis of PDMAEMA‐b‐PMMA‐b‐PNIPAM triblock block copolymer for preparing pH and thermal dual‐responsive PVDF blend membranes

Luo,

Wang,

Yan

et al. 2023

Polymer Engineering & Sci

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Functional membranes based on stimuli‐responsive block copolymers have attracted significant attention in the field of membrane separations, which can adjust the pore sizes and the surface properties in response to environmental stimuli. However, it was inconvenient to synthesize stimuli‐responsive block copolymers due to the complexity and inefficiency of the synthesis process. In this work, pH‐ and thermal‐responsive triblock copolymers were synthesized by the one‐pot method to modify PVDF membranes. The modified membranes exhibit good hydrophilicity, and the contact angle of M2 decreased from 74° to 0° within 20 s. Surprisingly, the water flux of the blend membrane is approximately 24 times and 33 times higher than that of the pure membrane, respectively. Besides, the modified membranes also exhibit good pH and thermal response, and superior fouling‐tolerant performance. Overall, these multi‐responsive block copolymers synthesized by a simple one‐pot method have enormous potential for controlled size separation, flux regulation, and many other fields.

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“…Noteworthily, temperature‐responsive polymers are the most appealing and well‐studied ones in the area of stimuli‐responsive polymers . Many of these polymers exhibit a lower critical solution temperature (LCST), below which the polymers are completely soluble in the solutions, while above which the polymers become insoluble .…”

Section: Introductionmentioning

confidence: 99%

A temperature‐responsive polyurethane and its biocompatible and biodegradable nanohydrogels with uniform cross‐linking networks

Xiao

Jiang

et al. 2019

Polymer Engineering & Sci

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We prepared a temperature‐responsive polyurethane (PU) with a coil‐to‐globule transition temperature of 36°C in aqueous media, by using polyethylene glycol‐4,000 (PEG‐4000), polycaprolactone diol‐1,000 (PCL‐1000), diphenylmethane diisocyanate‐50, and hydroxyethyl acrylate. Nanohydrogels were synthesized from temperature‐responsive PU through precipitation polymerization without employing a crosslinker. Due to the unique molecular structure of temperature‐responsive PU, PU nanohydrogels have uniform cross‐linking networks resulting in narrow volume phase transition temperature range, showing sensitive temperature responsiveness. Additionally, PEG and PCL segments provide PU nanohydrogels excellent biocompatibility and biodegradability, respectively. POLYM. ENG. SCI., 59:1517–1523 2019. © 2019 Society of Plastics Engineers

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Temperature‐responsiveness and sustained delivery properties of macroporous PEG‐co‐PNIPAAm‐co‐PCL hydrogels

Cited by 6 publications

References 43 publications

Biomimetic Polymers for Cardiac Tissue Engineering

Biomimetic Polymers for Cardiac Tissue Engineering

One‐pot three‐step synthesis of PDMAEMA‐b‐PMMA‐b‐PNIPAM triblock block copolymer for preparing pH and thermal dual‐responsive PVDF blend membranes

A temperature‐responsive polyurethane and its biocompatible and biodegradable nanohydrogels with uniform cross‐linking networks

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