Temperature‐Sensitive Artificial Channels through Pillar[5]arene‐based Host–Guest Interactions

Abstract

In living systems, temperature-sensitive ion channels play a vital role in numerous cellular processes and can be controlled by biological ion channels in response to specific temperature stimuli. Facile pillar[5]arene-based host-guest interactions are introduced into a nanochannel pattern for constructing a temperature-sensitive artificial channel. Ion transport was switched from cations to anions by controlling the extent of the host bound to the guest with temperature stimuli. This efect is mainly due to the changing of the inner surface charge and wettability of the nanochannel during the process. This study paves a new way for better understanding the mechanism of temperature-sensitive properties and shows great promise for biomedical research.

Applications of Pillar[n]arene‐Based Supramolecular Assemblies

“…Additionally,heating the host-guest complex crystals resulted in the encapsulated isooctane being recovered at ah igh purity (> 99 %), and the re-activated crystals H16 could be reused for octane-number improvement. [34] An anionic pillar [5]arene possessing 10 carboxylate groups H11 was used as ah ost. [31] Separation of these two compounds using conventional distillation is also difficult because of the small difference in b.p.…”

“…[33] Suitable guest moieties,that is,ionic liquid moieties were immobilized onto the surface of gold. [34].C opyright2 017 Wiley-VCH Verlag GmbH & Co.KGaA. Ah ydrophobic surface was induced by complexation with hydrophobic pillar [5]arene possessing anthracene groups H17 (Figure 13 b).…”

Surface Potential/Charge Sensing Techniques and Applications

“…Nanopores take advantage of the electrostatic effects inside nano-confined space in the presence of surface charges, which gives them high sensitivity and new sensing mechanisms [82]. The change in surface charge regulates the ionic conductance of nanopores through pH [83], divalent cations and anions [84], ionic concentrations [85], temperature [86], surface chemistry and biomolecules [87], gas [88], salt gradient and voltage polarity [13], and can be characterized by the current-voltage (I-V) curve due to the conductance change that is related to the inner wall surface charge regulation, or the instant current change related to the passing of charged particles through nanopores. The non-uniform distribution of surface charge inside the nanopore greatly affects the current rectification ratio.…”

One-, Two-, and Three-Dimensional Supramolecular Assemblies Based on Tubular and Regular Polygonal Structures of Pillar[ n ]arenes

“…Based on a temperature-responsive host-guest system, a temperature-regulated ion nanochannel was constructed (Figure 4c). 24 The host-guest interaction between an ionic liquid guest and watersoluble anionic pillar [5]arene host P[5]4 was thermally responsive. The complexation occurred at 25°C, but dissociation took place upon heating to 55°C.…”