Temperature-triggered redox-degradable poly(ether urethane) nanoparticles for controlled drug delivery

Synthesis and properties of temperature-sensitive and chemically crosslinkable poly(ether-urethane) hydrogel

“…The swelling ratio were measured by soaking the dried samples in a temperature-controlled bath of deionized water. The temperature of the water bath was adjusted to 20,25,30,33,35,37,40,45, and 50 °C. After 12 h of soaking, the samples were removed from the water bath and gently blotted with filter paper to remove the surface water, followed by immediate weighing.…”

“…Recently, many types of PEU have been used as biomaterials, 41,42 e.g., multi-responsive drug delivery systems, multi-responsive nanoparticles, and injectable hydrogels. [43][44][45][46][47] For multi-responsive PEUs, functional segments are incorporated into the backbone of PEU by a facile one-pot approach for temperature, pH and redox responses. Based on these multi-responsive PEUs, the important mechanism of injectable PEU gel formation is reversible temperatureresponsive physical cross-linking via hydrophobic interactions.…”

Single Polymer-drug Conjugate Carrying Two Drugs for Fixed-dose Codelivery

“…Moreover, for effective therapy, stimuli-responsive disulfide bond was used as a linker between PEG and dual drug conjugate to facilitate tumor relevant glutathione (GSH) triggered release. It is reported that under tumor-relevant reductive conditions, the disulfide-linked PEG could be cleaved and hence the drug release rate could be significantly accelerated from the assembled micelles [14][15][16][17][18][19][20][21].…”

Antifouling and biodegradable poly(N-hydroxyethyl acrylamide) (polyHEAA)-based nanogels

“…Biodegradable cross-linkers in polymer-based delivery systems in response to external stimuli such as temperature, pH, and light are oen used for the sustained release of drugs over a prolonged period. 26,27 All of these strategies have recently attracted signicant attention for the development of effective polymer-based delivery systems for current drugs, which are equally important for the development of new drugs, which is a very time-consuming and costly procedure. [27][28][29] We have recently synthesized a series of poly(N-hydroxyethyl acrylamide) (polyHEAA)-based materials for different bioapplications.…”