Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model

Zhang, Beiyuan; Gu, Qing; Chen, Xiancheng; Yong, You; Chen, Ming; Qian, Yajun; Yan, Chen; Yu, Wenkui

doi:10.1007/s12028-020-01083-2

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…Moreover, with the exception of one experiment realized in the setting of CS, 40 all other studies were conducted in CA models. 33 , 34 , 35 , 36 , 37 , 38 , 39 …”

Section: Induced Hypothermia In Animal Models Of Ecmomentioning

confidence: 99%

“…These studies showed several benefits from IH compared with the NT group. Regardless of the animal species, six studies demonstrated positive effects of IH on brain physiology by either resulting in better neurological outcomes (evaluated by neurological scores such as Neurologic Deficit Score or Overall Performance Category), 33 , 34 , 38 reducing neuronal deaths (assessed by histology and molecular biology), 33 , 36 , 39 or improving cerebral oxygenation. 36 IH was also associated with reduced myocardial necrosis on histological and blood samples 33 , 35 and improved haemodynamics.…”

Section: Induced Hypothermia In Animal Models Of Ecmomentioning

confidence: 99%

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The use of induced hypothermia in extracorporeal membrane oxygenation: A narrative review

et al. 2023

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“…Moreover, with the exception of one experiment realized in the setting of CS, 40 all other studies were conducted in CA models. 33 , 34 , 35 , 36 , 37 , 38 , 39 …”

Section: Induced Hypothermia In Animal Models Of Ecmomentioning

confidence: 99%

Section: Induced Hypothermia In Animal Models Of Ecmomentioning

confidence: 99%

The use of induced hypothermia in extracorporeal membrane oxygenation: A narrative review

et al. 2023

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“…Hypothermia can reduce CBF, reduce cerebral edema, decrease brain metabolism, reduce the production of ROS, reduce the release of excitatory amino acids and pro-inflammatory mediators, and inhibit apoptosis (82)(83)(84). TTM reduces endoplasmic reticulum stress-induced neuronal apoptosis, and changes in temperature within a certain sub-cold range do not diminish this protective effect (85,86). In a study in CA rats, it was shown that both TTM alone and inhaled molecular H 2 alone inhibited neuronal degeneration and microglia activation in vulnerable brain regions, with the combination of TTM and H 2 inhalation being the most effective treatment (87).…”

Section: Ttmmentioning

confidence: 99%

The effects of ECMO on neurological function recovery of critical patients: A double-edged sword

et al. 2023

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Extracorporeal membrane oxygenation (ECMO) played an important role in the treatment of patients with critical care such as cardiac arrest (CA) and acute respiratory distress syndrome. ECMO is gradually showing its advantages in terms of speed and effectiveness of circulatory support, as it provides adequate cerebral blood flow (CBF) to the patient and ensures the perfusion of organs. ECMO enhances patient survival and improves their neurological prognosis. However, ECMO-related brain complications are also important because of the high risk of death and the associated poor outcomes. We summarized the reported complications related to ECMO for patients with CA, such as north–south syndrome, hypoxic–ischemic brain injury, cerebral ischemia–reperfusion injury, impaired intracranial vascular autoregulation, embolic stroke, intracranial hemorrhage, and brain death. The exact mechanism of ECMO on the role of brain function is unclear. Here we review the pathophysiological mechanisms associated with ECMO in the protection of neurologic function in recent years, as well as the ECMO-related complications in brain and the means to improve it, to provide ideas for the treatment of brain function protection in CA patients.

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“…Therapeutic hypothermia (TH) (core temperature, 33-35°C) protects the endoplasmic reticulum from ultrastructural changes and reduces apoptosis of the cerebral cortex following cardiac arrest (CA) in experimental pigs. The reduction of neuronal apoptosis might occur through suppression of ER stress [ 29 ].…”

Section: Hypothermia and Endoplasmic Reticulummentioning

confidence: 99%

Research Progress of the Application of Hypothermia in the Eye

2020

Oxidative Medicine and Cellular Longevity

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Hypothermia is widely used in the medical field to protect organs or tissues from damage. Different research fields have different explanations of the protection mechanism of hypothermia. Hypothermia is also widely used in the field of ophthalmology, for example, in the eye bank, the preservation of corneal tissue and the preservation of the eyeball. Low temperature can also be applied to some ophthalmic diseases, such as allergic conjunctivitis, retinal ischemia, and retinal hypoxia. It is used to relieve eye symptoms or reduce tissue damage. Hypothermic techniques have important applications in ophthalmic surgery, such as corneal refractive surgery, vitrectomy surgery, and ciliary body cryotherapy for end-stage glaucoma. Hypothermia can reduce the inflammation of the cornea and protect the retinal tissue. The eyeball is a complex organ, including collagen tissue of the eyeball wall and retinal nerve tissue and retinal blood vessels. The mechanism of low temperature protecting eye tissue is complicated. It is important to understand the mechanism of hypothermia and its applications in ophthalmology. This review introduces the mechanism of hypothermia and its application in the eye banks, eye diseases (allergic conjunctivitis, retinal ischemia, and hypoxia), and eye surgeries (corneal transplant surgery, corneal refractive surgery, and vitrectomy).

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Temperature Variability Does Not Attenuate the Beneficial Effects of Therapeutic Hypothermia on Cellular Apoptosis and Endoplasmic Reticulum Stress in the Cerebral Cortex of a Swine Cardiac Arrest Model

Cited by 6 publications

References 28 publications

The use of induced hypothermia in extracorporeal membrane oxygenation: A narrative review

The use of induced hypothermia in extracorporeal membrane oxygenation: A narrative review

The effects of ECMO on neurological function recovery of critical patients: A double-edged sword

Research Progress of the Application of Hypothermia in the Eye

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