Template synthesis of polyazamacrocyclic compounds

Abstract

Compounds containing nitrogen in their cyclic backbone are one of the most representative groups of macrocyclic systems, and are very often synthesised by template reactions. The ligsons participating in the construction of ligand products must have certain groups or positions in moleculeswhich are sometimes concealed, revealing themselves when coordinated and activated by the template.Building up polyazamacrocyclic systems on the appropriate matrices is carried out by the interaction of compounds containing amine or imine groups with aldehydes, ketones, organic halogen derivatives, substituted malonic esters and ligsons containing unsaturated C-C bonds. The process may also be performed by interaction of the appropriate blocks, containing both functional groups necessary for obtaining the final product. Among such template reactions the most frequent is the formation of azomethine construction bonds, then C-N and C-C and in some cases, N=N chelatogene bonds.