Temporal Bone and Sinonasal Inverted Papilloma

Abstract

The expression of progesterone receptor in 1 of our 2 cases and in the only other case reported in the literature may imply some degree of hormonal dependence of temporal bone inverted papilloma. Our analysis of the expression of apoptosis-related proteins, markers of cell proliferation activity, and sex hormone receptors does not allow us to demonstrate that temporal bone and sinonasal inverted papilloma are different pathological entities.

Schneiderian papilloma of the temporal bone

“…Sex steroid hormones have been hypothesised to influence TBSP proliferation, because a rapid tumour growth has been observed during pregnancy 3. Until now, only four patients have been tested for oestrogen and progesterone receptor status, including the current case.…”

“…In TBSP, a degree of progesterone dependence has been suggested 3. Furthermore, higher recurrence and malignancy rates have been reported for TBSP as compared to sinonasal SP 1.…”

Sinonasal inverted papilloma: narrative review

“…The expression of progesterone receptors in some cases of temporal bone inverted papilloma may imply a certain degree of hormonal dependence. 18,19 There are conflicting reports in the literature as to whether sinonasal and middle-ear inverted papilloma involve the same pathology, as middle-ear inverted papilloma has higher rates of recurrence and of association with squamous cell carcinoma, compared with sinonasal inverted papilloma. 20,21 Aetiology The entire Schneiderian membrane (the embryological origin of the mucous membranes of the sinonasal cavity) are at risk of developing inverted papilloma.…”

Pathologie de l’oreille

“…Lésions exceptionnelles, elles sont morphologiquement semblables aux lésions du même nom des cavités nasosinusiennes [75,76]. Ils peuvent être associés à une localisation nasale ou nasopharyngée [77,78].…”