Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

Berkhout, M.C.; Rooden, Cornelis J. van; Aalbers, Ralph C.; Bouazzaoui, Lahssan H. el; Fokkens, Wytske J.; Rijntjes, E.; Heijerman, H.G.M.

doi:10.1002/lary.24575

Cited by 10 publications

(8 citation statements)

References 19 publications

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“…In PCD patients, who have otitis media with abnormal mucosal migration, the usual delayed pneumatization does not occur. In contrast to PCD, CF patients have a lower incidence of otitis media hyperpneumatization of the temporal bones . Without the inhibitory effect of otitis media in CF, delayed pneumatization does not occur.…”

Section: Resultsmentioning

confidence: 89%

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

et al. 2015

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Section: Resultsmentioning

confidence: 89%

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

et al. 2015

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“…Overall, the median survival time for CF patients is around 30 years, but children born in the United States in 1990 are projected to live longer than 40 years [1]. In 1989, the CF transmembrane conductance regulator (CFTR) gene was identified in the long arm of chromosome 7; its mutations can result in abnormal chloride ion transport [1–3]. …”

Section: Introductionmentioning

confidence: 99%

Changes in the inner ear structures in cystic fibrosis patients

Pauna

Monsanto

Kurata

et al. 2017

International Journal of Pediatric Otorhinolaryngology

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Objective Although prolonged use of antibiotics is very common in cystic fibrosis (CF) patients, no studies have assessed the changes in both cochlear and peripheral vestibular systems in this population. Methods We used human temporal bones to analyze the density of vestibular dark, transitional, and hair cells in specimens from CF patients who were exposed to several types of antibiotics, as compared with specimens from an age-matched control group with no history of ear disease or antibiotic use. Additionally, we analyzed the changes in the elements of the cochlea (hair cells, spiral ganglion neurons, and the area of the stria vascularis). Data was gathered using differential interference contrast microscopy and light microscopy. Results In the CF group, 83% of patients were exposed to some ototoxic drugs, such as aminoglycosides. As compared with the control group, the density of both type I and type II vestibular hair cells was significantly lower in all structures analyzed; the number of dark cells was significantly lower in the lateral and posterior semicircular canals. We noted a trend toward a lower number of both inner and outer cochlear hair cells at all turns of the cochlea. The number of spiral ganglion neurons in Rosenthal’s canal at the apical turn of the cochlea was significantly lower; furthermore, the area of the stria vascularis at the apical turn of the cochlea was significantly smaller. Conclusions Deterioration of cochlear and vestibular structures in CF patients might be related to their exposure to ototoxic antibiotics. Well-designed case-control studies are necessary to rule out the effect of CF itself.

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“…Temporal bone histology and mastoid pneumatization in patients with CF has also been studied. In general, it has been shown that patients with CF have well pneumatized mastoids [5,6,25,26]. Todd et al studied 20 patients and found that patients with cystic fibrosis had significantly less otitis media and better pneumatized mastoids than the population without CF [6].…”

Section: Discussionmentioning

confidence: 99%

Audiometric assessment of pediatric patients with cystic fibrosis

Kreicher

Bauschard

Clemmens

et al. 2018

Journal of Cystic Fibrosis

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This is the largest comprehensive analysis of all types of hearing loss in pediatric patients with CF. Our data suggest that children with more severe sinus disease may be at lower risk for inflammatory middle ear disease and subsequent hearing loss. Patients who develop complications of CF such as diabetes should be monitored frequently, and the use of ototoxic drugs should be limited if possible.

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Temporal bone pneumatization in cystic fibrosis: A correlation with genotype?

Abstract: 4.

Cited by 10 publications

References 19 publications

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

A new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction

Changes in the inner ear structures in cystic fibrosis patients

Audiometric assessment of pediatric patients with cystic fibrosis

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