Temporal changes in foveal contour after macular hole surgery

Abstract

Background To investigate the changes in inner foveal contour after surgery for macular hole (MH) and its clinical implications.

Arrested Foveal Development in Preterm Eyes: Thickening of the Outer Nuclear Layer and Structural Redistribution Within the Fovea

“…The inter-OPL distance, that is, the distance between the edges of the OPL, seems to have relevance as a clinical parameter as shown by Kim and colleagues. 39,40 They used the inter-OPL distance in clinical studies of the foveal structure following macular hole surgery to define the asymmetric elongation of foveal tissue central to the OPL edge as a possible effect of decreased postoperative foveolar stability after ILM peeling. In a recent study by another group the inter-OPL distance of the fellow eye was used to adjust for macular hole diameter and morphologic variations assuming that eyes with larger foveolar floor have larger hole diameter.…”

Asymmetrical steepening of the foveal contour after macular hole surgery with internal limiting membrane peeling

“…However, in the limited number of eyes without ILM peeling, the foveal slopes were steeper than that of the normal fellow eyes (data not shown). Recently, Kim et al measured the angle between an imaginary line parallel to the ELM and a line connecting the innermost retinal region of the foveal center and the edge of the outer plexiform layer (OPL) [23]. They also found an abrupt alteration of the inner contour of the foveal tissue, which they termed notching.…”

Outcome of Full-Thickness Macular Hole Surgery in Choroideremia

“…We described a FTMH in a patient with genetically confirmed CHM, which was successfully managed with pars plana vitrectomy, and ERM and ILM peeling, leading to a mild subjective improvement as well as improvement of retinal structure and function on OCT and microperimetry, respectively. The postoperative abnormal temporal foveal contour is a common occurrence following macular hole surgery [ 7 ], and may point to mechanical trauma, or to changes in the retinal microstructural stability due to ILM peeling. Central structural abnormalities on SD-OCT associated with CHM in this patient included outer retinal tubulations and a transition zone in relatively close proximity to the foveal centre, both of which have generally been noted to dictate caution when considering potential gene therapy trial inclusion [ 8 ], as mechanical trauma may further damage the already fragile photoreceptors.…”