Temporal Expression of TGF-β1, EGF, and PDGF-BB in a Model of Colonic Wound Healing

Buckmire, Michael A.; Parquet, Guido; Greenway, Scott; Rolandelli, Rolando H.

doi:10.1006/jsre.1998.5326

Cited by 41 publications

(32 citation statements)

References 35 publications

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“…Melatonin has been shown to induce production of TGF-β, [4] which plays a significant role in promoting collagen synthesis and healing the colon. [33] In the present study, TGF-β levels were higher in treated rats, corresponding to improved colonic healing. The present findings regarding the effect of melatonin on angiogenesis support those of previous studies.…”

Section: Groupssupporting

confidence: 57%

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Ersoy

Özkan

Özsoy

et al. 2015

Ulus Travma Acil Cerrahi Derg

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BACKGROUND:The present objective was to identify effects of early melatonin application on healing of anastomotic wound and inflammation in an experimental sepsis model. METHODS: A total of 60 Wistar albino rats were divided into 2 groups. Cecal ligation puncture (CLP) and colonic resection anastomosis were performed on both the control group and the melatonin treatment group. Both groups were divided into 3 subgroups consisting of 10 rats each. One subgroup from each group underwent re-laparotomy at the 16 th hour, the next on the 3 rd day, and the final subgroup on the 7 th day. Presently evaluated were effects of melatonin treatment of early sepsis on interleukin-6 (IL-6), interleukin-10 (IL-10), interferon gamma (INF-γ), and C-reactive protein (CRP) levels, as well as burst pressures (BPs), collagen and hydroxyproline (OHP) content of the anastomotic segments, histopathologic healing, immunohistochemical expressions, CD34, and transforming growth factor beta (TGF-β). RESULTS: IL-6 and INF-γ levels of the treatment group showed a significant decrease at the 16 th hour and an increase on the 3 rd and 7 th postoperative days. IL-10 levels were significantly higher at the 16 th hour and significantly lower on the 3 rd and 7 th postoperative days in the control group (p<0.001 for each). The treatment group also showed significantly higher capillary permeability, fibroblast proliferation, and collagen deposits (p<0.001 for each). CD34 expression was significantly increased in the treatment group on the 7

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Section: Groupssupporting

confidence: 57%

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Ersoy

Özkan

Özsoy

et al. 2015

Ulus Travma Acil Cerrahi Derg

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“…It is a member of a large family of structurally-related factors with varying activities and is found in three isomers, 1-3. the most important activities include fibroblast migration, maturation and the synthesis of extracellular matrix (49,50). tGF-β1 appears to play an important role in the metabolism of collagen (51,52). tGF-β is present in most cell types, especially in thrombocytes.…”

Section: Vascular Endothelial Growth Factor (Vegf)mentioning

confidence: 99%

Radiotherapy and wound healing: Principles, management and prospects (Review)

Gieringer

Gosepath²,

Naim³

2011

Oncol Rep

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Abstract. radiation therapy is a major therapeutic modality in the management of cancer patients. Over 60% of these patients receive radiotherapy at some point during their course of treatment and over 90% will develop skin reactions after therapy. problematic wound healing in radiation-damaged tissue constitutes a major surgical difficulty and despite all efforts, irradiated skin remains a therapeutic challenge. this review provides an overview of the fundamental principles of radiation therapy with regards to the wound healing in normal and irradiated skin. Furthermore, it presents techniques that describe how to prevent and manage skin side effects as well as prospects that may improve cutaneous wound repair in general and in irradiated skin.

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“…TGF-β is a member of a large family of structurally-related factors with varying activities and is found in three isomers, 1-3, whose most important activities include fibroblast migration, maturation and the synthesis of extracellular matrix (41). Specifically, TGF-β1 appears to play an important role in the metabolism of collagen (42). TGF is potentially an inhibitor of epithelial cell proliferation as it blocks the G1-phase in the eukaryotic cell cycle (43,44) and promotes angiogenesis (45,46).…”

Section: Growth Factors and Cytokinesmentioning

confidence: 99%

Keloids: Fundamental principles and prospects (Review)

Gieringer

Elliott²,

Gosepath³

et al. 2009

Mol Med Rep

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Abstract. Wound healing is a very complex process of interactions between different cells, growth factors, blood elements and extracellular matrix. Keloids represent one of the possible complications in the fundamental process of cutaneous wound repair. despite all efforts, keloids remain a therapeutic challenge since no treatment is as yet considered 100% effective. Growth factors, discovered in the late 1970s, have been shown to influence dermal regeneration. However, the exogenous application of growth factors to chronic wounds has not proven to be effective in healing them. additionally, genetic analysis has not revealed any single gene that might cause keloids; as such, classic gene therapy is not a feasible option for the treatment of keloids. a new approach is so-called somatic gene therapy. This review provides an overview of the fundamentals of wound healing and of keloids, and presents new possibilities that may improve cutaneous wound repair.

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Temporal Expression of TGF-β1, EGF, and PDGF-BB in a Model of Colonic Wound Healing

Cited by 41 publications

References 35 publications

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Effects of Melatonin on Cytokin Release and Healing of Colonic Anastomoses in an Experimental Sepsis Model

Radiotherapy and wound healing: Principles, management and prospects (Review)

Keloids: Fundamental principles and prospects (Review)

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