Temporal Relations between Cortical Network Oscillations and Breathing Frequency during REM Sleep

Tort, Adriano Bretanha Lopes; Hammer, Maximilian; Zhang, Jiaojiao; Brankačk, Jurij; Draguhn, Andreas

doi:10.1523/jneurosci.3067-20.2021

Cited by 43 publications

(34 citation statements)

References 105 publications

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“…Instead, a recent study has demonstrated that the direction of causality is from theta to respiration and not the reverse. This study also found evidence for a peripheral reafference signal in gamma oscillations, however, [36]. This peripheral reafference as well as studies showing that oral respiration can play a role [34] must be reconciled in this emerging field.…”

Section: Introductionsupporting

confidence: 59%

How the evolution of air breathing shaped hippocampal function

Jacobs

2021

Phil. Trans. R. Soc. B

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To make maps from airborne odours requires dynamic respiratory patterns. I propose that this constraint explains the modulation of memory by nasal respiration in mammals, including murine rodents (e.g. laboratory mouse, laboratory rat) and humans. My prior theories of limbic system evolution offer a framework to understand why this occurs. The answer begins with the evolution of nasal respiration in Devonian lobe-finned fishes. This evolutionary innovation led to adaptive radiations in chemosensory systems, including the emergence of the vomeronasal system and a specialization of the main olfactory system for spatial orientation. As mammals continued to radiate into environments hostile to spatial olfaction (air, water), there was a loss of hippocampal structure and function in lineages that evolved sensory modalities adapted to these new environments. Hence the independent evolution of echolocation in bats and toothed whales was accompanied by a loss of hippocampal structure (whales) and an absence of hippocampal theta oscillations during navigation (bats). In conclusion, models of hippocampal function that are divorced from considerations of ecology and evolution fall short of explaining hippocampal diversity across mammals and even hippocampal function in humans. This article is part of the theme issue ‘Systems neuroscience through the lens of evolutionary theory’.

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Section: Introductionsupporting

confidence: 59%

How the evolution of air breathing shaped hippocampal function

Jacobs

2021

Phil. Trans. R. Soc. B

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“…The temporal relationships between brain activity and the physiological signal are frequency dependent. For example, in mice, theta oscillations precede and are Granger-causal for the variation of respiration rate, whereas it is the opposite for the gamma oscillations (84). Our results support that at frequencies <0.5 Hz, the information mainly flows from brain to heart rate, outweighing the opposite direction.…”

Section: Discussionmentioning

confidence: 99%

Active neural coordination of motor behaviors with internal states

Zhang

Takahashi

Hady

et al. 2021

Preprint

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The brain continuously coordinates skeletomuscular movements with internal physiological states like arousal, but how is this coordination achieved? One possibility is that brain simply reacts to changes in external and/or internal signals. Another possibility is that it is actively coordinating both external and internal activities. We used functional ultrasound imaging to capture a large medial section of the brain, including multiple cortical and subcortical areas, in marmoset monkeys while monitoring their spontaneous movements and cardiac activity. By analyzing the causal ordering of these different time-series, we found that information flowing from the brain to movements and heart rate fluctuations were significantly greater than in the opposite direction. The brain areas involved in this external versus internal coordination were spatially distinct but also extensively interconnected. Temporally, the brain alternated between network states for this regulation. These findings suggest that the brain’s dynamics actively and efficiently coordinate motor behavior with internal physiology.

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“…These relationships between respiration and cognitive processes suggest a specific role for respiration as a timing signal for brain activity 69 . For instance, it has been shown that the respiratory rate shapes olfactory memory 70,71 , emotions 72 , and reaction time 73 , and coordinates the coupling of brain oscillations during sleep [74][75][76] as well as during wakefulness [77][78][79][80][81][82] . These results indicate that cardiorespiratory activity contribute to the shaping of attention and perception, and relative changes in respiration and heart rates are part of ongoing bidirectional brain-heart interplay processes 83 , similar to emotions or stress 84,85 .…”

Section: Monitoring Of Visceral Activitymentioning

confidence: 99%

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

Candia-Rivera

Sappia

Horschig³

et al. 2022

Preprint

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Recent studies have established that cardiac and respiratory phases can modulate perception and related neural dynamics. While heart rate and respiratory sinus arrhythmia are possibly affecting interoception biomarkers, such as heartbeat-evoked potentials, the relative changes in heart rate and cardiorespiratory dynamics in interoceptive processes have not yet been investigated. In this study, we investigated the variation in heart and respiration rates, as well as higher functional dynamics including cardiorespiratory correlation and frontal hemodynamics, during cardiac awareness tasks. To further investigate the functional physiology linked to changes in vagal activity caused by specific respiratory rates, we studied cardiac awareness and controlled respiration rate. The results demonstrate that focusing on heartbeats decreases respiration and heart rates in comparison, which may be part of the physiological mechanisms related to 'listening' to the heart, the focus of attention, and self-awareness. Focusing on heartbeats was also observed to increase frontal connectivity, supporting the role of frontal structures in the neural monitoring of visceral inputs. However, cardiorespiratory correlation is affected by both interoceptive and controlled respiration. Based on these results, we concluded that variations in heart and respiratory rates are confounding factors in the assessment of interoceptive abilities and relative fluctuations in respiration and heart rates should be considered to be a mode of covariate measurement of interoceptive processes.

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Temporal Relations between Cortical Network Oscillations and Breathing Frequency during REM Sleep

Cited by 43 publications

References 105 publications

How the evolution of air breathing shaped hippocampal function

How the evolution of air breathing shaped hippocampal function

Active neural coordination of motor behaviors with internal states

Confounding effects of heart rate, breathing rate, and frontal fNIRS on interoception

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