Temporal relationships among uterine pituitary adenylate cyclase-activating polypeptide, decidual prolactin-related protein and progesterone receptor mRNAs expressions during decidualization and gestation in rats

Spencer, Fitzgerald; Chi, Limen; Zhu, Maoshu

doi:10.1016/s1532-0456(01)00177-6

Cited by 14 publications

(11 citation statements)

References 30 publications

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“…17,18) It has been reported that PR is expressed in the rat placenta, and that both PR-A and PR-B are in JEG-3 cells, a subclone of BeWo cells. 19,20) Taking all of these facts into consideration, it is thought that progesterone might be involved in the inhibition of other steroid receptors that induces ABCG2 in the placenta through PR-A activation.…”

Section: Discussionmentioning

confidence: 99%

Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation

Yasuda

Itagaki

Hirano

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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The aim of this study was to elucidate the expression pattern of ABCG2 in the placenta from the mid stage to the end of gestation. rABCG2 expression was investigated in rats on the 14th gestation day (gd) and the 20th gd. Expression of the rABCG2 gene and expression of rABCG2 protein in the placenta were detected on gd 14 by RT-PCR and Western blot analysis respectively. The expression level of rABCG2 on gd 20 was less than that on gd 14. We investigated whether progesterone, secreted from the placenta, regulates the expression of ABCG2 in BeWo cells. Expression levels of the ABCG2 gene and protein in BeWo cells were decreased by progesterone treatment. We conclude that progesterone plays a role in reduction in the expression level of ABCG2 in the placenta with the advance of gestation from the mid stage to the end of gestation.

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Section: Discussionmentioning

confidence: 99%

Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation

Yasuda

Itagaki

Hirano

et al. 2005

Bioscience, Biotechnology, and Biochemistry

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“…In the ovary, the concentration of PACAP is much lower than in the testis, and the peptide seems to be contained in nerve fibers (Steenstrup et al, 1995). In the uterus, decidual endometrium contains significant amounts of PACAP mRNA (Spencer et al, 2001). The occurrence of PACAP and PACAP mRNA has been reported in both rat and human placenta.…”

Section: F Distribution Of Pituitary Adenylate Cyclaseactivating Polmentioning

confidence: 99%

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

et al. 2009

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“…These observations indicate that PACAP may be involved in the regulation of the uteroplacental blood flow. The time-related localization of endometrial/ uterine PACAP was described by Spencer et al [45]. PACAP mRNA pattern showed similarity with that of the progesterone receptor during decidualization, but it was consistently lower during gestation.…”

Section: Effects Of Pacap In Vessels Of the Placentamentioning

confidence: 67%

“…Butadiene diepoxide is a reactive metabolite of 1,3-butadiene that is an important industrial chemical and causes a dose-dependent inhibition of deciduoma development in rats [44,45]. Placental expression of PACAP mRNA significantly decreased in rats pretreated with 1,3-butadiene, a chemical toxin for reproduction in rats [44,46].…”

Section: Expression Of Pacap In Pathological Pregnanciesmentioning

confidence: 99%

Occurrence and Functions of PACAP in the Placenta

Horváth

Németh

Brubel

et al. 2016

Current Topics in Neurotoxicity

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Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide with a widespread distribution both in the nervous system and peripheral organs. The peptide is also present in the female gonadal system, indicating its role in reproductive functions. While a lot of data are known on PACAP-induced effects in oogenesis and in the regulation of gonadotropin secretion at pituitary level, its placental effects are somewhat neglected in spite of the documented implantation deficit in mice lacking endogenous PACAP. The aim of the present review is to give a brief summary on the occurrence and actions of PACAP and its receptors in the placenta. Radioimmunoassay (RIA) measurements revealed increased serum PACAP levels during the third trimester and several changes in placental PACAP content in obstetrical pathological conditions, further supporting the function of PACAP during pregnancy. Both the peptide and its receptors have been shown in different parts of the placenta and the umbilical cord. PACAP influences blood vessel and smooth muscle contractility of the uteroplacental unit and is involved in regulation of local hormone secretion. The effects of PACAP on trophoblast cells have been mainly studied in vitro. Effects of PACAP on cell survival, angiogenesis and invasion/proliferation have been described in different trophoblast cell lines. PACAP increases proliferation and decreases invasion in proliferative extravillous trophoblast cells, but not in primary trophoblast cells, where PACAP decreased the secretion of various angiogenic markers. PACAP pretreatment enhances survival of non-tumorous primary trophoblast cells exposed to oxidative stress, but it does not influence the cell death-inducing effects of methotrexate in proliferative extravillous cytotrophoblast cells. Interestingly, PACAP has pro-apoptotic effect in choriocarcinoma cells suggesting that the effect of PACAP depends on the type of trophoblast cells. These data strongly support that PACAP plays a role in normal and pathological pregnancies and our review provides an overview of currently available experimental data worth to be further investigated to elucidate the exact role of this peptide in the placenta. Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) is an endogenous neuropeptide with a widespread distribution both in the nervous system and peripheral organs. The peptide is also present in the female gonadal system, indicating its role in reproductive functions. While a lot of data are known on PACAP-induced effects in oogenesis and in the regulation of gonadotropin secretion at pituitary level, its placental effects are somewhat neglected in spite of the documented implantation deficit in mice lacking endogenous PACAP. The aim of the present review is to give a brief summary on the occurrence and actions of PACAP and its receptors in the placenta. Radioimmunoassay (RIA) measurements revealed increased serum PACAP levels during the third trimester and several changes in placental PACAP conten...

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Temporal relationships among uterine pituitary adenylate cyclase-activating polypeptide, decidual prolactin-related protein and progesterone receptor mRNAs expressions during decidualization and gestation in rats

Cited by 14 publications

References 30 publications

Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation

Expression Level of ABCG2 in the Placenta Decreases from the Mid Stage to the End of Gestation

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

Occurrence and Functions of PACAP in the Placenta

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