Temporal Stability of Individual Differences in Amygdala Reactivity

Manuck, Stephen B.; Brown, Brienne; Forbes, Erika E.; Hariri, Ahmad R.

doi:10.1176/appi.ajp.2007.07040609

Cited by 96 publications

(86 citation statements)

References 9 publications

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“…A canonical face processing task (Hariri et al, 2000) was collected at age 20 (see Supplementary Figure S1). The experimental task included four face processing blocks interleaved with five sensorimotor control blocks (Manuck et al, 2007;Carré et al, 2012;Hyde et al, 2014Hyde et al, , 2015. In the face processing block participants viewed one face in the upper half of the screen and two faces in the bottom half of the screen.…”

Section: Methodsmentioning

confidence: 99%

Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later

Mattson

Hyde

Shaw

et al. 2016

Social Cognitive and Affective Neuroscience

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Depression is linked to increased amygdala activation to neutral and negatively valenced facial expressions. Amygdala activation may be predictive of changes in depressive symptoms over time. However, most studies in this area have focused on small, predominantly female and homogenous clinical samples. Studies are needed to examine how amygdala reactivity relates to the course of depressive symptoms dimensionally, prospectively and in populations diverse in gender, race and socioeconomic status. A total of 156 men from predominately low-income backgrounds completed an fMRI task where they viewed emotional facial expressions. Left and right amygdala reactivity to neutral, but not angry or fearful, facial expressions relative to a non-face baseline at age 20 predicted greater depressive symptoms 2 years later, controlling for age 20 depressive symptoms. Heightened bilateral amygdala reactivity to neutral facial expressions predicted increases in depressive symptoms 2 years later in a large community sample. Neutral facial expressions are affectively ambiguous and a tendency to interpret these stimuli negatively may reflect to cognitive biases that lead to increases in depressive symptoms over time. Individual differences in amygdala reactivity to neutral facial expressions appear to identify those at most risk for a more problematic course of depressive symptoms across time.

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Section: Methodsmentioning

confidence: 99%

Clinical neuroprediction: Amygdala reactivity predicts depressive symptoms 2 years later

Mattson

Hyde

Shaw

et al. 2016

Social Cognitive and Affective Neuroscience

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“…Indeed, other studies have provided decidedly less optimistic results (Johnstone et al, 2005;Manoach et al, 2001;Manuck, Brown, Forbes, & Hariri, 2007). For example, Johnstone et al 2005 investigated the test-retest reliability of amygdala reactivity to neutral and fearful faces across three testing occasions spanning 8 weeks.…”

Section: Reliabilitymentioning

confidence: 99%

“…ICCs peaked around 0.8 in the left amygdala, but were near zero in the right amygdala for several contrasts. Manuck et al 2007 conducted a similar study but with a longer (1 year) test-retest interval. In contrast to Johnstone et al's results, Manuck et al found moderate stability in the right amygdala (r = 0.59) but no stability in the left amygdala (r = −0.08).…”

Section: Reliabilitymentioning

confidence: 99%

Intelligence and Cognitive Control

Chuderski

Nęcka²

2010

Handbook of Individual Differences in Cognition

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“…The collective results of these studies suggest that relatively heightened amygdala activation to environmental threat may mediate the association between the 5-HTTLPR S allele and increased trait negative affect, as well as risk for mood and anxiety disorders, especially in response to chronic or severe stress. Recent evidence of traitlike stability for individual differences in amygdala activation measured with fMRI over both short (2-and 8-week) and long (> 1 year) intervals (23,24) further underscores the possible and potentially unique role of the amygdala in mediating effects of the 5-HTTLPR on enduring aspects of temperament and personality.…”

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confidence: 98%