Temporal trend of circulating trans-fatty acids and risk of long-term mortality in general population

Wang, Shanjie; Tian, Wei; Liu, Yige; Yan, Guangcan; Fang, Shaohong; Wang, Ya-Feng; Yu, Bo

doi:10.1016/j.clnu.2020.07.010

Cited by 24 publications

(24 citation statements)

References 31 publications

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“…All data were extracted from the National Health and Nutrition Examination Surveys (NHANES) conducted by the Center for Disease Control and Prevention of the United States. As described in our previous reports [ 19 ], NHANES is an ongoing, national, stratified, and multistage probability sample to investigate the health status of the non-institutionalized civilian population of all ages. In the current study, 26,661 participants 20 years or older in five 2-year NHANES cycles (1999–2000, 2001–2002, 2003–2004, 2011–2012, and 2013–2014) were included.…”

Section: Methodsmentioning

confidence: 99%

“…Ever smokers were defined as participants who ever smoked at least 100 cigarettes but quitting now. Leisure physical activity during the past month was classified as vigorous, moderate, and less exercise as our previous described [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

“…All participants aged 18 years or older in NHANES were linked to the National Death Index with a unique sequence number until December 31, 2015 [ 19 ]. The leading cause of death was ascertained according to the codes of International Classification of Diseases 10th Revision (ICD-10).…”

Section: Methodsmentioning

confidence: 99%

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Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Wang

Liu

et al. 2020

Redox Biology

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Background Inherited methylmalonic acidemia is characterized by mitochondrial dysfunction, oxidative stress, and damage of mitochondria-rich organs in children. It is unclear whether methylmalonic acid (MMA) is related to poor prognosis in adults. The study aims to investigate the associations of MMA with all-cause and cause-specific mortality in the general population. Methods Overall, 23,437 adults from the US National Health and Nutrition Examination Survey (NHANES) were enrolled. NHANES 1999–2004 and 2011–2014 were separately used as primary and validation subsets (median follow-up 13.5 and 2.8 years, respectively). Circulating MMA was measured with gas chromatography/mass spectrophotometry. Hazard ratios (HR) were estimated using weighted Cox regression models. Results During 163,632 person-years of follow-up in NHANES 1999–2004, 3019 deaths occurred. Compared with participants with MMA <120 nmol/L, those with MMA≥250 nmol/L had increased all-cause and cardiovascular mortality in the multivariable-adjusted model [HR(95%CI), 1.62 (1.43–1.84) and 1.66 (1.22–2.27), respectively]. The association was especially significant among participants with normal cobalamin. MMA remained an independent predictor of all-cause mortality occurring whether within 5-year, 5–10 years, or beyond 10-year of follow-up (each p for trend≤0.007). That association was repeatable in NHANES 2011–2014. Moreover, baseline MMA improved reclassiﬁcation for 10-year mortality in patients with cardiovascular disease (net reclassification index 0.239, integrated discrimination improvement 0.022), overmatched established cardiovascular biomarkers C-reactive protein or homocysteine. Conclusions Circulating level of mitochondrial-derived MMA is strongly associated with elevated all-cause and cardiovascular mortality. Our results support MMA as a surrogate biomarker of mitochondrial dysfunction to predict poor prognosis in adults. The biological mechanisms under cardiovascular disease warrant further investigation.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Wang

Liu

et al. 2020

Redox Biology

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“…Demographic and lifestyle factors at baseline, including age, gender, race/ethnicity, smoke, alcohol intake, and physical activity, and family income level were recorded during personal interviews via standardized questionnaires [ 21 , 22 ]. Physical examinations were performed according to standardized protocols and processes at a mobile examination center.…”

Section: Methodsmentioning

confidence: 99%

“…The outcomes of this study were total and cause-specific mortality. All participants were linked to the National Death Index in the National Center for Health Statistics of the US [ 21 , 22 ]. Mortality data were available through December 31, 2015.…”

Section: Methodsmentioning

confidence: 99%

U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study

et al. 2020

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Background Serum uric acid (UA) is involved in the development of hypertension. However, its impact on mortality in hypertension remains unclear. We aimed to assess the association of cardiovascular and all-cause mortality with UA in a hypertensive population. Material/Methods This study included 15 583 hypertensive patients from the NHANES study during 1999–2014. Weighted Cox regression analyses and cubic spline fitting were used to assess the relationship between UA and mortality risk. Results Over a median follow-up of 7.4 years (116 351 person-years), a total of 3291 deaths occurred. Mortality was examined according to 5 predefined UA levels: ≤3.5, 3.5–5, 5–6, 6–7.5, and >7.5 mg/dL. In multivariable analysis with 5–6 mg/dL as a reference, the hazard ratios (95% confidence interval) of total mortality across the 5 groups were 1.40 (1.05–1.88), 1.08 (0.95–1.21), 1.00 (reference), 1.14 (1.02–1.29), and 1.74 (1.50–2.02), respectively. According to a restricted cubic spline, we noted a U-shaped relationship between UA and total mortality. The U-shaped relationship between UA and cardiovascular mortality remained in both females and males. The increased cardiovascular mortality in the lowest and highest UA groups was attributed to stroke and heart-specific mortality, respectively. However, serum UA was not significantly associated with cancer mortality. Conclusions Our findings showed a U-shaped relationship between serum UA levels and total and cardiovascular mortality in patients with hypertension. Furthermore, low UA was associated with stroke mortality, while higher UA was associated with heart-related mortality. Further research is needed to identify the potential mechanisms of UA in hypertension.

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Evidence-based European recommendations for the dietary management of diabetes

Aas¹,

Axelsen²,

Churuangsuk³

et al. 2023

Diabetologia

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Temporal trend of circulating trans-fatty acids and risk of long-term mortality in general population

Cited by 24 publications

References 31 publications

Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

Mitochondria-derived methylmalonic acid, a surrogate biomarker of mitochondrial dysfunction and oxidative stress, predicts all-cause and cardiovascular mortality in the general population

U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study

Evidence-based European recommendations for the dietary management of diabetes

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