The Sangha River basin is the largest sub-basin of the Congo River basin, which drains the northern part of the Republic of the Congo-Brazzaville. It is the most important economic zone in this part of the country, with a strong timber industry, agriculture and hydroelectricity. The catchment also boasts the country's third-largest river port, located in the town of Ouesso. Unfortunately, increasingly frequent low-water levels in recent years have led to a decline in river navigation and economic activities. So, the aim of this study is to show the effects of climate change over the last six decades in the Sangha watershed at Ouesso hydrological station, located in the north of the Republic of the Congo-Brazzaville, and elucidate its impact on water resources. To achieve this, several statistical and hydrological methods were used. The application of change-point or shift detection tests to flow series from 1961 to 2020 revealed variability in the hydrological cycle, characterized by two major phases of homogeneous flows: a wet surplus phase and a dry deficit phase. The results show one shift in flood flows in 1971 (Buishand test), one shift in yearly average flows or modules in 1971 (Pettitt test and Buishand test), and one shift in low-water flows in 1976, with all two tests. These disruptions were accompanied by a drop in flow of around 15.63%, 21.70% and 35.67%, on average, for floods, modules, and low-water, respectively, a drop in rainfall of around 9.6% and a rise in temperature of around 0.76˚C. These flows show an overall downward trend. The calculated recession coefficients show that, over the entire study period, a recession occurred in March 1985.