Temporomandibular disorders in immune-mediated rheumatic diseases of the adult: A systematic review

Hysa, Elvis; Lercara, Adriano; Cere, A.; Gotelli, Emanuele; Gerli, Veronica; Paolino, Sabrina; Pizzorni, Carmen; Sulli, Alberto; Smith, Vanessa; Cutolo, Maurizio

doi:10.1016/j.semarthrit.2023.152215

“…The candidate mediators included nine psychology‐related traits (depression, feeling lonely, miserable, guilty, fed‐up, nervous, worry, hurt, and tense), 19,20 four smoking and dietary behaviours (ever smoked, smoking initial, cigarettes smoked per day, alcohol intake frequency), 21 three adiposity traits (body mass index [BMI], waist‐to‐hip ratio [WHR], body fat percentage), 22 five sleep‐related traits (apnea, snoring, insomnia, daytime sleepiness, sleep duration), 23,24 one physical activity (moderate to vigorous physical activity levels), 19 two autoimmune disorders (systemic lupus erythematosus [SLE], Sjogren's syndrome [SS]), 25 insufficient Vitamin D (vitamin D supplement, serum 25‐Hydroxyvitamin D levels), 25 estradiol levels in females and males, 26 lower back pain 27 and average total household income 28 . Detailed information on all GWAS included in our study is shown in Table S2.…”

Section: Methodsmentioning

confidence: 99%

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Chen,

Cheng,

Xu

et al. 2024

J of Oral Rehabilitation

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BackgroundAs one of the most important indicators of socioeconomic status, educational attainment (EA) exhibits a strong association with temporomandibular disorders (TMDs). Despite this link, there is a lack of evidence regarding the causal role of EA in either facilitating or preventing TMDs.ObjectiveThis study aimed to investigate the causal effect of education on TMDs and explore potential mediating pathways.MethodsUtilizing summary statistics from genome‐wide association studies on years of schooling (N = 766 345) and TMDs (N = 211 023), we conducted Mendelian randomization (MR) to assess the overall effect of education. Additionally, a two‐step MR approach was employed to evaluate 30 potential mediators and calculate the mediation proportions in the association. Comprehensive sensitivity analyses were used to verify the robustness, heterogeneity, and pleiotropy.ResultsUnivariable MR analyses revealed a causal effect of lower EA on an increased risk of TMDs (OR: 0.53, 95% CI: 0.43–0.66, p < .001). Five out of 30 modifiable factors were identified as causal mediators in the associations of EA with TMDs, including feeling nervous (mediation proportion: 11.6%), feeling tense (10.2%), depression (9.6%), feeling worry (7.6%) and daily smoking (8.9%). Meanwhile, no pleiotropy was detected in the analyses (p > .05).ConclusionOur findings supported that higher EA has a protective effect on the onset of TMDs, with partial mediation by psychological disorders and daily smoking. Interventions on these factors thus have the potential of substantially reducing the burden of TMDs attributed to low education.

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“…The temporomandibular joint (TMJ) is one of the most complex structures to study, requiring that the occlusion, joint, muscles, ligaments, and psychological factors are in complete harmony. In line with this, the person mustn't have harmful habits to all of these structures cited [1,2]. In this sense, the TMJ can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis [2,3].…”

Section: Introductionmentioning

confidence: 97%

“…In line with this, the person mustn't have harmful habits to all of these structures cited [1,2]. In this sense, the TMJ can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis [2,3].…”

Section: Introductionmentioning

confidence: 97%

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Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review

Gubert,

Mercante,

Polidoro

et al. 2024

MedNEXT

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Introduction: The temporomandibular joint (TMJ) can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis. Around 70% of the general population has suffered at least one symptom of temporomandibular disorder (TMD), which constitutes TMJ disease that may be related to the joints, muscles, ligaments, bones, teeth, and psychological aspects. As a treatment, the implantation of a total alloplastic TMJ prosthesis is an innovative approach. Objective: It was to present the main considerations and outcomes of clinical studies on the treatments of temporomandibular disorders using customized or prefabricated prostheses. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from February to April 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 121 articles were found, 40 articles were evaluated in full and 21 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 22 studies with a high risk of bias and 10 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=57.8%>50%. It was concluded that stock and CAD/CAM prostheses suggested great improvements in mouth opening and pain reduction as a result of the rehabilitation of TMJ function. The results showed comparable data for both types of prosthesis design at 6 months postoperatively. However, the additional advantages of custom prosthetics, along with increasing access to digital technology, will likely result in custom devices dominating the market in TMJ total joint replacement systems. The custom-made combined prosthesis with custom design and 3D printing fabrication represents a safe and reliable implantable reconstruction method for combined TMJ-skull base injuries.

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“…The temporomandibular joint (TMJ) is one of the most complex structures to study, requiring that the occlusion, joint, muscles, ligaments, and psychological factors are in complete harmony. In line with this, the person mustn't have harmful habits to all of these structures cited [1,2]. In this sense, the TMJ can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis [2,3].…”

Section: Introductionmentioning

confidence: 97%

Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review

Gubert,

Mercante,

Polidoro

et al. 2024

MedNEXT

0

View full text Add to dashboard Cite

Introduction: The temporomandibular joint (TMJ) can be affected by end-stage pathologies, such as arthritic disease, trauma, and ankylosis. Around 70% of the general population has suffered at least one symptom of temporomandibular disorder (TMD), which constitutes TMJ disease that may be related to the joints, muscles, ligaments, bones, teeth, and psychological aspects. As a treatment, the implantation of a total alloplastic TMJ prosthesis is an innovative approach. Objective: It was to present the main considerations and outcomes of clinical studies on the treatments of temporomandibular disorders using customized or prefabricated prostheses. Methods: The PRISMA Platform systematic review rules were followed. The search was carried out from February to April 2024 in the Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar databases. The quality of the studies was based on the GRADE instrument and the risk of bias was analyzed according to the Cochrane instrument. Results and Conclusion: A total of 121 articles were found, 40 articles were evaluated in full and 21 were included and developed in the present systematic review study. Considering the Cochrane tool for risk of bias, the overall assessment resulted in 22 studies with a high risk of bias and 10 studies that did not meet GRADE and AMSTAR-2. Most studies did not show homogeneity in their results, with X2=57.8%>50%. It was concluded that stock and CAD/CAM prostheses suggested great improvements in mouth opening and pain reduction as a result of the rehabilitation of TMJ function. The results showed comparable data for both types of prosthesis design at 6 months postoperatively. However, the additional advantages of custom prosthetics, along with increasing access to digital technology, will likely result in custom devices dominating the market in TMJ total joint replacement systems. The custom-made combined prosthesis with custom design and 3D printing fabrication represents a safe and reliable implantable reconstruction method for combined TMJ-skull base injuries.

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Temporomandibular disorders in immune-mediated rheumatic diseases of the adult: A systematic review

Cited by 10 publications

References 81 publications

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Causal effects of educational attainment on temporomandibular disorders and the mediating pathways: A Mendelian randomization study

Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review

Major considerations and outcomes of clinical studies on the treatment of temporomandibular disorders using prostheses: a systematic review

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