Temporomandibular joint forces measured at the condyle of Macaca arctoides

Boyd, Robert L.; Gibbs, Charles H.; Mahan, Parker E.; Richmond, Arthur F.; Laskin, Jeffrey L.

doi:10.1016/s0889-5406(05)80027-7

Cited by 95 publications

(34 citation statements)

References 10 publications

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“…5,6 Induced modifications in functional loading by softening the ingredients of daily food consumption or suppression of biting capacity through the induction of constant disocclusion of teeth (trimming of incisors) have been well recognized as common epigenetic factors, contributing to reduced masticatory force levels being delivered to the temporomandibular joint (TMJ) and the mandibular condyles. [7][8][9] Research in the direction of collagen disorders (rheumatoid arthritis, osteogenesis imperfecta, Ehlers-Danlos syndrome, Stickler syndrome, Marfan syndrome) has shed light on the involvement of genetic factors in the bone/cartilage architectural alterations. 10,11 Collagen represents the most abundant matrix protein, either as type I (bone) or type II (cartilage), and comprises three major polypeptide chains, resulting in fibril formation cross-linked to each other.…”

Section: Introductionmentioning

confidence: 99%

The effect of rheumatoid arthritis and functional loading on the structure of the mandibular condyle in a transgenic mouse model: An FTIR study

Koletsi

Eliades

Zinelis

et al. 2016

Archives of Oral Biology

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OBJECTIVE: The objective of the present study was to investigate the effect of rheumatoid arthritis and functional loading through diet modification on the biochemical properties of the mandibular condyle in a transgenic mouse model and compare with healthy littermates. DESIGN: Twenty three, 4-week old hybrid male mice were used. Eleven were of transgenic line hTNF 197 (Tg 197 -with rheumatoid arthritis -RA) and 12 healthy littermates, both from mixed background CBAxC57BL/6. Four groups of mice were formed. Group 1 [n =5, RA-hard] included transgenic mice and received ordinary (hard) diet; group 2 [n=6, RA-soft] included transgenic line and received soft diet; group 3 [n=6, control-hard] were healthy littermates receiving ordinary (hard) diet and group 4 [n=6, control-soft] were healthy littermates with soft diet. Experimental period was 28 days. Following sacrifice, the mandibular condyles were subjected to micro-attenuated reflection Fourier transform infrared spectroscopy (micro-ATR FTIR) to reveal collagen/proteoglycan conformation of the condylar cartilage, while resin-embedded and metallographically polished specimens were evaluated through reflection FTIR microscopy to identify mineralization status of the corresponding condylar bone. RESULTS: The multivariable analysis revealed significantly lower a-helix to amide I percentage area ratio for the transgenic animals after adjusting for diet (=-4.29, 95% CIs: -8.52, -0.06; p=0.04). Mineral phase indices did not differ significantly between RA and control groups regardless the type of diet. CONCLUSIONS: Internal derangement of the anatomical structure with denaturation in the collagen structural components of the mandibular condyles of the RA animals was found, while no association with functional loading through diet modification was recorded. Following sacrifice, the mandibular condyles were subjected to micro-attenuated reflection Fourier transform infrared spectroscopy (micro-ATR FTIR) to reveal collagen/proteoglycan conformation of the condylar cartilage, while resin-embedded and metallographically polished specimens were evaluated through reflection FTIR microscopy to identify mineralization status of the corresponding condylar bone. Results:The multivariable analysis revealed significantly lower a-helix to amide I percentage area ratio for the transgenic animals after adjusting for diet p=0.04).Mineral phase indices did not differ significantly between RA and control groups regardless the type of diet. Conclusions:Internal derangement of the anatomical structure with denaturation in the collagen structural components of the mandibular condyles of the RA animals was found, while no association with functional loading through diet modification was recorded.

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Section: Introductionmentioning

confidence: 99%

The effect of rheumatoid arthritis and functional loading on the structure of the mandibular condyle in a transgenic mouse model: An FTIR study

Koletsi

Eliades

Zinelis

et al. 2016

Archives of Oral Biology

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“…The mandibular condyle is subject to a complex set of loading conditions during chewing as it translates and rotates on the glenoid region of the temporal bone (Hylander, 1979;Boyd et al, 1990;Herring and Liu, 2001). The trabecular bone of the condyle transfers these condylar reaction forces to the cortical shell of the ramus during masticatory and ingestive behaviors (Herring and Liu, 2001).…”

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confidence: 99%

Trabecular bone structure in the mandibular condyles of gouging and nongouging platyrrhine primates

Ryan

Colbert

Ketcham

et al. 2009

American J Phys Anthropol

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The relationship between mandibular form and biomechanical function is a topic of significant interest to morphologists and paleontologists alike. Several previous studies have examined the morphology of the mandible in gouging and nongouging primates as a means of understanding the anatomical correlates of this feeding behavior. The goal of the current study was to quantify the trabecular bone structure of the mandibular condyle of gouging and nongouging primates to assess the functional morphology of the jaw in these animals. High-resolution computed tomography scan data were collected from the mandibles of five adult common marmosets (Callithrix jacchus), saddle-back tamarins (Saguinus fuscicollis), and squirrel monkeys (Saimiri sciureus), respectively, and various three-dimensional morphometric parameters were measured from the condylar trabecular bone. No significant differences were found among the taxa for most trabecular bone structural features. Importantly, no mechanically significant parameters, such as bone volume fraction and degree of anisotropy, were found to vary significantly between gouging and nongouging primates. The lack of significant differences in mechanically relevant structural parameters among these three platyrrhine taxa may suggest that gouging as a habitual dietary behavior does not involve significantly higher loads on the mandibular condyle than other masticatory behaviors. Alternatively, the similarities in trabecular architecture across these three taxa may indicate that trabecular bone is relatively unimportant mechanically in the condyle of these primates and therefore is functionally uninformative.

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“…Joint function remains normal as long as its adaptive capacity is not compromised [11, 49, 50, 51, 52, 53, 54, 55, 56]. Parafunction such as clenching is a good example of repetitive jaw motion associated with possible high TMJ impact loading that leads to the conversion of shearing stresses into compressive stresses [52, 54].…”

Section: Joint Overloading and Impaired Lubricationmentioning

confidence: 99%

“…Very little is known about the actual forces involved in TMJ function in situ, but weights of up to 17.7 kg have been recorded in Macaca monkeys [55, 56]. Chen and Xu [56]found contact stress in human TMJ reached a maximum of 1,650 lb/inch 2 , which is similar to that in the hip and knee joints.…”

Section: Control Of Tmj Overloadingmentioning

confidence: 99%

‘Friction and Adhesive Forces’ – Possible Underlying Causes for Temporomandibular Joint Internal Derangement

Nitzan

2003

Cells Tissues Organs

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Since normal temporomandibular joint (TMJ) movements depend primarily on the disc freely sliding down the slope of the eminence, understanding how aberrations in the lubrication system contribute to TMJ dysfunction is clearly critically important. It provides a possible explanation for the genesis of disc displacement and helps make us familiar with the clinical appearance and ways of treating limited mouth opening caused by the anchored disc phenomenon (ADP) versus disc displacement without reduction, TMJ open lock versus dislocation and osteoarthritis. This understanding clarifies the efficiency of procedures such as joint hydraulic pump, arthrocentesis and arthroscopic lavage and lysis particularly in ADP, open lock and osteoarthritis.

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Temporomandibular joint forces measured at the condyle of Macaca arctoides

Cited by 95 publications

References 10 publications

The effect of rheumatoid arthritis and functional loading on the structure of the mandibular condyle in a transgenic mouse model: An FTIR study

The effect of rheumatoid arthritis and functional loading on the structure of the mandibular condyle in a transgenic mouse model: An FTIR study

Trabecular bone structure in the mandibular condyles of gouging and nongouging platyrrhine primates

‘Friction and Adhesive Forces’ – Possible Underlying Causes for Temporomandibular Joint Internal Derangement

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