Ten-m2 Is Required for the Generation of Binocular Visual Circuits

Young, T. R.; Bourke, Michael J.; Zhou, Xin; Oohashi, Toshitaka; Sawatari, Atomu; Fässler, Reinhard; Leamey, Catherine A.

doi:10.1523/jneurosci.4708-12.2013

Cited by 67 publications

(88 citation statements)

References 56 publications

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“…Both the ipsilateral and ectopic patches were eliminated upon pharmacological blockade of retinal waves, indicating that their refinement was activity-dependent. This finding is contrast with a study lacking Ten-m2 (Ten-m2 KO), a member of the teneurin family of glycoproteins, which show a decrease number of ipsilateral projections but normal segregation of ipsi- and contralateral inputs (Young et al, 2013). It would be interesting to combine these genetic manipulations with reconstructions of single axon termination zones to observe whether the process of axon branch refinement occurs in a similar manner to wild type mice.…”

Section: Learning Rules Of Activity-dependent Circuit Maturationcontrasting

confidence: 97%

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

Kirkby

Sack

Firl

et al. 2013

Neuron

297

251

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Before the onset of sensory transduction, developing neural circuits spontaneously generate correlated activity in distinct spatial and temporal patterns. During this period of patterned activity, sensory maps develop and initial coarse connections are refined, which are critical steps in the establishment of adult neural circuits. Over the last decade there has been substantial evidence that altering the pattern of spontaneous activity disrupts refinement, but the mechanistic understanding of this process remains incomplete. In this review, we discuss recent experimental and theoretical progress towards the process of activity-dependent refinement, focusing on circuits in the visual, auditory and motor systems. While many outstanding questions remain, the combination of several novel approaches have brought us closer to a comprehensive understanding of how complex neural circuits are established by patterned spontaneous activity during development.

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Section: Learning Rules Of Activity-dependent Circuit Maturationcontrasting

confidence: 97%

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

Kirkby

Sack

Firl

et al. 2013

Neuron

297

251

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“…In the absence of Ten‐m3, projections from the lateral PF remained strictly ipsilateral and confined to the matrix, as in WT mice, suggesting that laterality and compartmentalisation cues are preserved in the thalamostriatal pathway of KOs. Similarly, no changes in laterality were observed in projections within the visual pathway of Ten‐m3 KO mice, although some usually ipsilaterally projecting retinal axons were found to project contralaterally following the deletion of the closely‐related Ten‐m2 protein (Young et al ., ). The observation that compartmentalisation of thalamostriatal projections was unaltered in KOs is consistent with our findings that the presence and positioning of striosomes were not significantly altered in the absence of Ten‐m3.…”

Section: Discussionmentioning

confidence: 98%

The glycoprotein Ten‐m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice

Tran

Sawatari

Leamey

2014

Eur J of Neuroscience

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The striatum is the key input nucleus of the basal ganglia, and is implicated in motor control and learning. Despite the importance of striatal circuits, the mechanisms associated with their development are not well established. Previously, Ten-m3, a member of the Ten-m/teneurin/odz family of transmembrane glycoproteins, was found to be important in the mapping of binocular visual pathways. Here, we investigated a potential role for Ten-m3 in striatal circuit formation. In situ hybridisation revealed a patchy distribution of Ten-m3 mRNA expression superimposed on a high-dorsal to low-ventral gradient in a subregion of the striatal matrix. A survey of afferent/efferent structures associated with the matrix identified the parafascicular thalamic nucleus (PF) as a potential locus of action. Ten-m3 was also found to be expressed in a high-dorsal to low-ventral gradient in the PF, corresponding topographically to its expression in the striatum. Further, a subset of thalamic terminal clusters overlapped with Ten-m3-positive domains within the striatal matrix. Studies in wild-type (WT) and Ten-m3 knockout (KO) mice revealed no differences in overall striatal or PF structure. Thalamostriatal terminals in KOs, however, while still confined to the matrix subregion, lost their clustered appearance. Topography was also altered, with terminals from the lateral PF projecting ectopically to ventral and medial striatum, rather than remaining confined dorsolaterally as in WTs. Behaviorally, Ten-m3 KOs displayed delayed motor skill acquisition. This study demonstrates that Ten-m3 plays a key role in directing the formation of thalamostriatal circuitry, the first molecular candidate reported to regulate connectivity within this pathway.

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“…Complementary but nonoverlapping expression of TEN in the Drosophila olfactory system and the mice cerebellum, hippocampus, and visual pathway (retina, dorsal lateral geniculate nucleus, superior culiculus, and visual cortex) suggests that their homophilic interactions could instruct interneuronal connections (75,76). Indeed, this role has been substantiated by studies done on the Drosophila olfactory system and the mouse visual system, in which they are suspected to direct axon targeting events (72,73,77,78). The function of TEN in the nervous system also involves the promotion of neurite outgrowth, cell adhesion, dendritic morphology, and synapse formation.…”

Section: Heterophilic Interactions Teneurinsmentioning

confidence: 98%

Latrophilins updated

Meza-Aguilar

Boucard

2014

Biomolecular Concepts

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Latrophilins (LPHN) are part of a yet unexplored family of receptors comprising three isoforms, LPHN1-3, and belonging to a unique branch of G protein-coupled receptors (GPCR) named adhesion GPCR (aGPCR). LPHN are considered to be prototypical models for the study of aGPCR as they are one of the most evolutionary conserved members. Previously described as the target for a potent neurotoxin from the black widow spider venom, LPHN are now being studied under a whole new perspective. Indeed, recent advances have provided a better understanding of different aspects of this prototypical family of receptors: 1) elucidation of LPHN ectodomain organization by crystallography has unveiled a new functional domain with great repercussion on all the other members of the aGPCR family, 2) proteomic approaches have opened the gate to unsuspected functional characteristics of LPHN cellular role, and 3) genetic approaches have provided hints into the physiological functions of LPHN in specific systems and organisms. Moreover, genomic linkage studies screening human patients from diverse genetic backgrounds have involved LPHN gene defects in human disorders such as attention-deficit hyperactivity disorder and cancer. In this review, we will provide a historical perspective addressing experimental research on these receptors while highlighting the new advances and discoveries concerning LPHN functions. As GPCR still represent the most studied targets for the development of pharmacological approaches aiming at alleviating human disorders, the relevance of studying LPHN retains a high pertinence to better understand these receptors for the treatment of human diseases.

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Ten-m2 Is Required for the Generation of Binocular Visual Circuits

Cited by 67 publications

References 56 publications

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

A Role for Correlated Spontaneous Activity in the Assembly of Neural Circuits

The glycoprotein Ten‐m3 mediates topography and patterning of thalamostriatal projections from the parafascicular nucleus in mice

Latrophilins updated

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