Ten new glycosides, carissaedulosides A–J from the root barks of Carissa edulis and their cytotoxicities

Kaunda, Joseph Sakah; Qin, Xu‐Jie; Yang, Xuebo; Mwitari, Peter; Zhu, Hongtao; Wang, Dong; Zhang, Yingjun

doi:10.1016/j.bioorg.2020.104097

Cited by 6 publications

(8 citation statements)

References 41 publications

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“…The free TCG showed 25, 22, and 17 % cytotoxicity compared with 26, 20, and 11 % for LMWC‐Cbl‐TCG at a concentration of 100, 10, and 1 μg/ml, respectively (Figure 6). The half‐maximal inhibitory concentration (IC50) values expressing the concentrations responsible for 50 % growth inhibition were also calculated [29] . The results indicated insignificant cytotoxicity, in which the IC50 obtained for all samples containing TCG, LMWC‐Cbl, and LMWC‐Cbl‐TCG was >200 μg/ml against the HEK 293 cell lines.…”

Section: Resultsmentioning

confidence: 99%

Design and Characterization of Ticagrelor‐Loaded Chitosan Biopolymer to Improve Chemical and Biological Properties of the Drug

Hosseini-Ashtiani

Tadjarodi

2021

ChemistrySelect

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The present study aimed at proposing a safe drug delivery system comprising of chitosan, as a natural polymer, and cyanocobalamin (Cbl) in compliance with the biological system to improve oral administration of ticagrelor (TCG). To this end, the drug loading, in‐vitro drug release, and in‐vitro cytotoxicity were assessed after fabricating the drug‐loaded carrier. Drug transfer could be improved due to the inherent features of mucoadhesive chitosan and the existence of a specific receptor for Cbl in the intestine. Given the results, a maximum drug loading efficiency of 80 % was obtained for TCG, and a controlled release profile was achieved for the drug‐loaded carrier in 0.2 % w/v polysorbate 80 in water. Biocompatibility studies of the TCG‐loaded carrier showed similar cytotoxicity compared to the free drug. The proposed safe drug delivery system has the potentials to overcome the constraints that might preclude the use of the TCG formulation in oral dosage forms.

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Section: Resultsmentioning

confidence: 99%

Design and Characterization of Ticagrelor‐Loaded Chitosan Biopolymer to Improve Chemical and Biological Properties of the Drug

Hosseini-Ashtiani

Tadjarodi

2021

ChemistrySelect

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“…Kaunda et al [94] isolated three furofuran lignans (carissaeduloside H, carissaeduloside I, and carissaeduloside J ( 26)) together with 12 analogues (sarhamnoloside (22)…”

Section: Lignansmentioning

confidence: 99%

“…C. spinarum). Out of these compounds, sarhamnoloside (22) and [(1S,2S,3S)-1,2,3,4tetrahydro-3,7-dihydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-(hydroxyl-methyl)-6-methoxy-2naphthalen-yl] methyl β-D-glucopyranoside (51) exhibited anticancer activity against lung and breast cancer cell lines [94] (Table 5).…”

Section: Lignansmentioning

confidence: 99%

“…A coumarin-secoirdoid hybrid named carissaeduloside G was isolated from the root bark of C. edulis (syn. C. spinarum) [94].…”

Section: Coumarinsmentioning

confidence: 99%

“…Six glycosides (carissaeduloside A (24), carissaeduloside B, carissaeduloside C, carissaeduloside D (25), carissaeduloside E, and carissaeduloside F) were isolated from the root bark of C. edulis (syn. C. spinarum) [94]. Out of all of these, carissaedulosides A (24) and carissaedulosides D (25) have been reported for their cytotoxic effects (Table 5) against cancer cell lines [94].…”

Section: Cardiac Glycosidesmentioning

confidence: 99%

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Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review

et al. 2021

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Carissa, a genus of the Apocynaceae family, consists of evergreen species, such as shrubs as well as small trees that are native to Asia, Africa, and Oceania’s subtropical and tropical regions. Most of the Carissa species are traditionally used to treat various diseases, such as chest pain, headaches, gonorrhoea, rheumatism, syphilis, oedema, rabies, stomach pain, hepatitis, cardiac diseases, and asthma. The pharmacological studies on Carissa species revealed its antioxidant, antimicrobial, anticancer, cardioprotective, antipyretic, analgesic, wound healing, anticonvulsant, antiarthritic, adaptogenic, anti-inflammatory, and antidiabetic activities, thus validating its use in indigenous medicine systems. The review article summarised the comprehensive literature available, including morphology, indigenous uses, bioactive composition, nutraceutical, and pharmacological activities of Carissa species. A total of 155 research papers were cited in this review article. The Carissa fruits are rich in dietary fibre, lipids, proteins, carbohydrates, vitamin C, and macro- and micro-elements. A total of 121 compounds (35 polyphenols (flavonoids and phenolic acids), 30 lignans, 41 terpenoids, 7 steroids, 2 coumarins, and 6 cardiac glycosides) have been extracted from C. spinarum, C. carandas, and C. macrocarpa. Among all chemical constituents, lupeol, carissol, naringin, carisssone, scopoletin, carissaeduloside A, D, J, carandinol, sarhamnoloside, carissanol, olivil, carinol, 3β-hydroxyolean-11-en-28,13β-oilde, ursolic acid, and carissone are the key bioactive constituents responsible for pharmacological activities of genus Carissa. The gathered ethnopharmacological information in the review will help to understand the therapeutic relevance of Carissa as well as paving a way for further exploration in the discovery of novel plant-based drugs.

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In vitro cytotoxic activities of selected Saudi medicinal plants against human malignant melanoma cells (A375) and the isolation of their active principles

Alqathama

Bader

Al‐Rehaily

et al. 2022

European Journal of Integrative Medicine

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Ten new glycosides, carissaedulosides A–J from the root barks of Carissa edulis and their cytotoxicities

Cited by 6 publications

References 41 publications

Design and Characterization of Ticagrelor‐Loaded Chitosan Biopolymer to Improve Chemical and Biological Properties of the Drug

Design and Characterization of Ticagrelor‐Loaded Chitosan Biopolymer to Improve Chemical and Biological Properties of the Drug

Phytochemistry, Pharmacology, and Nutraceutical Profile of Carissa Species: An Updated Review

In vitro cytotoxic activities of selected Saudi medicinal plants against human malignant melanoma cells (A375) and the isolation of their active principles

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