Ten-year patient survival on maintenance haemodialysis: association with treatment time and dialysis dose

Singh, Seema; Choi, P.; Power, Albert; Ashby, Damien; Cairns, Thomas; Griffith, Megan; McLean, Adam; Palmer, Andrew J.; Taube, David; Duncan, Neill

doi:10.5301/jn.5000234

Cited by 19 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Following reports of centres employing long-term extended daytime HD demonstrating significantly improved five-and ten-year patient survival rates of 73% and 54% respectively (Charra et al 1992, Chazot & Jean 2008, the focus has switched to intensive dialysis regimens (Gotch et al 2013) Our local observational data (Singh et al 2013) concurs with findings from international registries that longer treatment time is associated with lower mortality risk (Tentori et al 2012). Consequently, the Frequent Haemodialysis Network (FHN) (Chertow et al 2010) were commissioned to review the relationships between daily short duration HD and daily long duration nocturnal HD in randomised controlled trials.…”

Section: B I O D a T Asupporting

confidence: 73%

Survey of Staff Opinions About Extended Haemodialysis Treatment Time and Service Implications

Singh

Procter

Power

et al. 2015

Journal of Renal Care

Self Cite

View full text Add to dashboard Cite

There is conflict between the understanding that extended TT is clinically beneficial and its prescription & delivery to patients. Enrolment to studies examining HD delivery strategies may be influenced by service provision and staff attitudes. In centre HD has been designed to maximise patient throughput and we may need to consider more flexible settings in which to deliver longer treatment time: Home HD maybe a solution.

show abstract

Section: B I O D a T Asupporting

confidence: 73%

Survey of Staff Opinions About Extended Haemodialysis Treatment Time and Service Implications

Singh

Procter

Power

et al. 2015

Journal of Renal Care

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another reason for overall high mortality in our study was the long follow-up period in the study. To the best of our knowledge, there have been few studies conducted where the study examined the effect of dialysis efficiency in an incident cohort of hemodialysis patients with long-term follow-up [ 14 – 16 ]. The overall 10-year mortality rate in available studies was 75% [ 16 ] that coincides with the mortality rate reported in our analysis.…”

Section: Discussionmentioning

confidence: 99%

Association of Dose and Frequency on the Survival of Patients on Maintenance of Hemodialysis in China: A Kaplan-Meier and Cox-Proportional Hazard Model Analysis

Sun

Wang

et al. 2018

Med Sci Monit

View full text Add to dashboard Cite

BackgroundDialysis frequency and dose are controversial prognostic factors of hemodialysis morbidity and mortality. The aim of this study was to find out the effect of frequency and dosage of dialysis on mortality and survival in a group of Chinese hemodialysis patients.Material/MethodsIn total, 183 patients seen from February 2008 to January 2018, who were on maintenance hemodialysis for at least 3 months, were included in the study cohort. An anonymized database of age, gender, diabetic status, comorbidities, date of initiation of dialysis, hematological characters, biochemical variables, and status of survived or died was established from DICOM (Digital Imaging and Communications in Medicine) files of patients. Kaplan-Meier and Cox-proportional hazard model was used for calculation of survival over time at 95% confidence level.ResultsOverall, the 10-year survival rate was 27%. Kaplan-Meier analysis showed patient survival as 94% at one-year, 59% at 5-years, and 27% at 10-years. Hemoglobin, serum albumin, calcium, potassium, phosphorous, calcium-phosphorous-products, and hemodialysis frequency and the dose had a significant effect on survival. Cox regression proportional hazard model showed that patients with serum albumin level of >4 g/dL were better associated with survival. Patients who underwent twice-weekly hemodialysis had 4.26 times less chance of survival as compared to patients with thrice-weekly hemodialysis. A higher dialysis dose of >1.2 spKt/V offered better survival as compared to a lower dose of <1.2 spKt/V.ConclusionsHypoalbuminemia, hemodialysis time, and hemodialysis frequency were significantly associated with mortality.

show abstract

“…Kt/V is the commonly used marker for dialysis adequacy [1]. Kt/V can be modified by efficiency of dialyzer, duration of dialysis, dialysis frequency, dialysate flow rate and dialyzer blood flow rate (BFR) [2-4]. …”

Section: Introductionmentioning

confidence: 99%

The impact of blood flow rate during hemodialysis on all-cause mortality

Chang

Kim

et al. 2016

Korean J Intern Med

View full text Add to dashboard Cite

Background/AimsInadequacy of dialysis is associated with morbidity and mortality in chronic hemodialysis (HD) patients. Blood flow rate (BFR) during HD is one of the important determinants of increasing dialysis dose. However, the optimal BFR is unclear. In this study, we investigated the impact of the BFR on all-cause mortality in chronic HD patients.MethodsPrevalent HD patients were selected from Clinical Research Center registry for end-stage renal disease cohort in Korea. We categorized patients into two groups by BFR < 250 and ≥ 250 mL/min according to the median value of BFR 250 mL/min in this study. The primary outcome was all-cause mortality.ResultsA total of 1,129 prevalent HD patients were included. The number of patients in the BFR < 250 mL/min was 271 (24%) and in the BFR ≥ 250 mL/min was 858 (76%). The median follow-up period was 30 months. Kaplan-Meier analysis showed that the mortality rate was significantly higher in patients with BFR < 250 mL/min than those with BFR ≥ 250 mL/min (p = 0.042, log-rank). In the multivariate Cox regression analyses, patients with BFR < 250 mL/min had higher all-cause mortality than those with BFR ≥ 250 mL/min (hazard ratio, 1.66; 95% confidence interval, 1.00 to 2.73; p = 0.048).ConclusionsOur data showed that BFR < 250 mL/min during HD was associated with higher all-cause mortality in chronic HD patients.

show abstract

Ten-year patient survival on maintenance haemodialysis: association with treatment time and dialysis dose

Abstract: Extended treatment times are associated with higher patient survival irrespective of dialysis dose. Further study of extended treatment time and effect on patient outcomes is needed.

Cited by 19 publications

References 0 publications

Survey of Staff Opinions About Extended Haemodialysis Treatment Time and Service Implications

Survey of Staff Opinions About Extended Haemodialysis Treatment Time and Service Implications

Association of Dose and Frequency on the Survival of Patients on Maintenance of Hemodialysis in China: A Kaplan-Meier and Cox-Proportional Hazard Model Analysis

The impact of blood flow rate during hemodialysis on all-cause mortality

Contact Info

Product

Resources

About