Ten-year stability of self-reported schizotypal personality features in patients with psychosis and their healthy siblings

Moreno-Izco, Lucía; Sánchez‐Torres, Ana M.; Lorente-Omeñaca, Ruth; Fañanás, Lourdes; Rosa, Araceli; Salvatore, Paola; Peralta, Víctor; Cuesta, Manuel J.

doi:10.1016/j.psychres.2015.02.020

Cited by 16 publications

(7 citation statements)

References 58 publications

(89 reference statements)

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“…PDs are defined as being “stable over time,” 28 so it is possible that PD symptoms are similarly stable, which has been corroborated by recent evidence in schizotypal PD. 39 Since PDs are not typically diagnosed for young teenagers, their stability between adolescence and adulthood has not been ascertained. Some work has shown moderate stability in schizotypal PD symptoms between early (ages 11–13) and middle (ages 14–16) adolescence.…”

Section: Discussionmentioning

confidence: 99%

Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms

Watsky

Pollard

Greenstein

et al. 2016

Journal of the American Academy of Child & Adolescent Psych

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Objective This study investigated the relationship between regional cortical gray matter thinning and symptoms of schizophrenia spectrum personality disorders (PDs) in siblings of patients with childhood-onset schizophrenia (COS). Method 66 siblings of patients with COS were assessed for symptoms of schizophrenia spectrum PDs (avoidant, paranoid, schizoid, schizotypal). Structural magnetic resonance images were obtained at approximately 2-year intervals from the siblings and from 62 healthy volunteers, matched for age, sex, ethnicity, and handedness. Cortical thickness measures were extracted. Mixed effect regression models were used to test the relationship between symptoms and cortical gray matter thickness. Cortical thinning was also tested longitudinally in healthy volunteers and siblings. Results Cortical thinning was found to correlate with symptoms of schizotypal and, to a lesser extent, schizoid PDs. Thinning was most pronounced in the left temporal and parietal lobes and right frontal and parietal regions. Gray matter loss was found to be continuous with that measured in COS. Longitudinal thinning trajectories were found not to differ between siblings and healthy volunteers. Conclusion The present investigation of cortical thinning in siblings of patients with COS indicates that symptoms of schizophrenia spectrum PDs correlate with regional gray matter loss. This finding supports the idea of cortical thinning as a schizophrenia endophenotype.

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Section: Discussionmentioning

confidence: 99%

Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms

Watsky

Pollard

Greenstein

et al. 2016

Journal of the American Academy of Child & Adolescent Psych

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“…As both the SPQ and SPQ-B are intended for adults, an equivalent reliable 22-item version SPQ-C with minor modifications is available for children ( α = 0.91; [ 19 •]). The three-factor structure of schizotypy is found to be stable across time and instrument for the SPQ [ 15 ] and SPQ-B [ 20 ], international populations of psychiatric patients [ 21 – 24 ], community adults [ 25 – 27 ], and adolescents [ 19 •, 28 ] and is invariant across gender, religion, ethnicity, and social backgrounds [ 26 , 29 ]. The SPQ and its subsequent brief versions are psychometrically robust, where a higher score often reflects greater neurobiological and genetic vulnerabilities [ 30 , 31 ], thus offering researchers a tool to assess the etiology of schizotypy across development.…”

Section: Assessmentsmentioning

confidence: 99%

Developmental Aspects of Schizotypy and Suspiciousness: a Review

Wong

Raine

2018

Curr Behav Neurosci Rep

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Purpose of the ReviewThis review identifies the early developmental processes that contribute to schizotypy and suspiciousness in adolescence and adulthood. It includes the most recent literature on these phenomena in childhood.Recent FindingsThe early developmental processes that affect schizotypy and paranoia in later life are complex. In contrast to existing studies of psychiatric patients and clinical/nonclinical adult populations, the study of schizotypy and suspiciousness in young children and adolescents is possible due to new child-appropriate dimensional assessments. New assessments and the advancement of technology (e.g., virtual reality in mental health) as well as statistical modeling (e.g., mediation and latent-class analyses) in large data have helped identified the developmental aspects (e.g., psychosocial, neurocognitive and brain factors, nutrition, and childhood correlates) that predict schizotypy and suspiciousness in later life.SummaryProspective longitudinal designs in community youths can enhance our understanding of the etiology of schizophrenia-spectrum disorders and, in the future, the development of preventive interventions by extending adult theories and interventions to younger populations.

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“…The SPQ-B has been used with patients and relatives of patients with schizophrenia-spectrum disorders (Compton et al, 2007;Moreno-Izco et al, 2015), adolescents (Fonseca-Pedrero et al, 2009), twins (Ericson et al, 2011), outpatients (Axelrod et al, 2001), and college students (Compton et al, 2009a;Fonseca-Pedrero et al, 2011;Mata et al, 2005;Raine and Benishay, 1995). The psychometric properties of the SPQ-B have been examined previously.…”

Section: Introductionmentioning

confidence: 99%

Brief assessment of schizotypal traits: A multinational study

Fonseca‐Pedrero

Ortuño‐Sierra

Lucas‐Molina

et al. 2018

Schizophrenia Research

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The Schizotypal Personality Questionnaire-Brief (SPQ-B) was developed with the aim of examining variations in healthy trait schizotypy, as well as latent vulnerability to psychotic-spectrum disorders. No previous study has studied the cross-cultural validity of the SPQ-B in a large cross-national sample. The main goal of the present study was to analyze the reliability and the internal structure of SPQ-B scores in a multinational sample of 28,426 participants recruited from 14 countries. The mean age was 22.63years (SD=7.08; range 16-68years), 37.7% (n=10,711) were men. The omega coefficients were high, ranging from 0.86 to 0.92 for the total sample. Confirmatory factor analysis revealed that SPQ-B items were grouped either in a theoretical structure of three first-order factors (Cognitive-Perceptual, Interpersonal, and Disorganized) or in a bifactor model (three first-order factors plus a general factor of schizotypal personality). In addition, the results supported configural but not strong measurement invariance of SPQ-B scores across samples. These findings provide new information about the factor structure of schizotypal personality, and support the validity and utility of the SPQ-B, a brief and easy tool for assessing self-reported schizotypal traits, in cross-national research. Theoretical and clinical implications for diagnostic systems, psychosis models, and cross-national mental health strategies are derived from these results.

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Ten-year stability of self-reported schizotypal personality features in patients with psychosis and their healthy siblings

Cited by 16 publications

References 58 publications

Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms

Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms

Developmental Aspects of Schizotypy and Suspiciousness: a Review

Brief assessment of schizotypal traits: A multinational study

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