Ten-year trends in hospital admissions for adverse drug reactions in England 1999–2009

Abstract

SummaryObjectives Adverse drug reactions (ADR) are an important cause of morbidity and mortality. We analysed trends in hospital admissions associated with ADRs in English hospitals between 1999 and 2008.

Detection of adverse drug reaction (ADR)-related hospital admissions: A pilot study using administrative database for ADR monitoring in Thailand

“…Our findings are in line with that of the previous review in which the rate of ADRs ranged from 0.16% to 15.7% 6 . Our findings are also in line with previous studies that use similar method to identify ADRs but slightly higher: Spain 1.69% 12 , England 0.5% to 0.9% 15,19 , Portugal 1.26%…”

“…As the result, administrative database has substantial potential to be continuously used to monitor ADRs for national perspective as supplement to established methods such as spontaneous report. In fact, the use of hospital administrative data is proven to be a reliable and valid method for monitoring patient's safety in several developed countries [12][13][14][15][16][17][18][19] . To our knowledge, no study has been conducted to determine the prevalence of ADR among hospitalized patients in less developed country using administrative database before.…”

Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

“…In developed countries, drugs account for 20% of community-acquired AKI episodes that result in hospitalization 137,138 . Drug-associated AKI (DA-AKI) occurs in approximately 25% of critically ill patients, making drugs a common cause of AKI in the ICU 28,139,140 .…”

Adverse events recorded in English primary care: observational study using the General Practice Research Database

“…7,8 Research on iatrogenic harm in nonacute care has focused on drug-related events and tended to rely on data from a single care setting and obtained from a limited number of sources, resulting in potential under-estimation of the true rate of patient harm. [9][10][11] A comprehensive estimate of adverse events in primary care is lacking, especially as existing safety monitoring systems such as the National Reporting and Learning System are inadequate for detecting events in the primary care setting, and may be affected by under-reporting. 12,13 Other methods for monitoring and learning from adverse events, at the practice level, include significant event audits and trigger tools but they also have limitations.…”