Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening

Kurtovic-Kozaric, Amina; Mehinović, Lejla; Malesevic, Radmila; Mešanović, Semir; Jaroš, Tijana; Stomornjak-Vukadin, Meliha; Mackic-Djurovic, Mirela; Ibrulj, Slavica; Kurtovic-Basic, Ilvana; Kozaric, Mirza

doi:10.1016/j.ejogrb.2016.08.038

Cited by 20 publications

(16 citation statements)

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“…Down syndrome (DS) is the most common human genetic disorder (Lubec & Engidawork 2002) and one of the leading causes of intellectual disabilities (IDs) (Handen et al 2012) with 20-22 individuals per 10 000 births affected (Kurtovic-Kozaric et al 2016;Loane et al 2013). More than 99% of individuals with DS have an extra copy of the entire chromosome 21.…”

Section: Introductionmentioning

confidence: 99%

Designed game situations enhance fundamental movement skills in children with Down syndrome

Regaieg

Kermarrec

Sahli

2020

J intellect Disabil Res

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Background This study aimed to compare the effects of a designed program based on games situations with those of a conventional one, the Adapted Physical Education (APE) program, on the fundamental movement skills (FMS) in children with Down Syndrome (DS), aged 6 to 10. Methods Twenty‐eight children (13 girls and 15 boys; age 8.84 ± 1.06) with DS participated in this study. The participants were divided into two groups as the experimental group (EG) with 13 children (3 girls and 10 boys) and the control group (CG) composed with 15 children (10 girls and 5 boys). The EG participated in a conceived training program based on games situations along 10 weeks, while the CG took part in an APE conventional program based on football, long Jump and sprint adapted exercises. The FMS (locomotor and object control skills) were evaluated using the Gross Motor Development‐2 Test at pretraining and posttraining for both groups. Results The results revealed that both programs improve significantly locomotor skills with significantly better improvement in the EG. However, a significant object control skills improvement was observed only among the EG. Conclusions In light of our findings, a training program based on adapted games situations during 10 weeks may be recommended for FMS improvement, specifically object control skills.

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Section: Introductionmentioning

confidence: 99%

Designed game situations enhance fundamental movement skills in children with Down syndrome

Regaieg

Kermarrec

Sahli

2020

J intellect Disabil Res

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“…Even though Down syndrome is the most common chromosomal cause of intellectual disability, with 20–22 individuals per 10,000 births affected (e.g., Kurtovic-Kozaric et al, 2016, Loane et al, 2013), studies on early development are scarce. Infants with Down syndrome are known to be socially competent but show a delay in the acquisition of motor milestones and deficits in early gesture production (Grieco, Pulsifer, Seligsohn, Skotko, & Schwartz, 2015; Özcaliskan, Adamson, Dimitrova, Bailey, & Schmuck, 2016; Saito & Watanabe, 2016).…”

Section: Introductionmentioning

confidence: 99%

The motor repertoire in 3- to 5-month old infants with Down syndrome

Herrero

Einspieler

Aizawa

et al. 2017

Research in Developmental Disabilities

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BackgroundEven though Down syndrome is the most common chromosomal cause of intellectual disability, studies on early development are scarce.AimTo describe movements and postures in 3- to 5-month-old infants with Down syndrome and assess the relation between pre- and perinatal risk factors and the eventual motor performance.Methods and proceduresExploratory study; 47 infants with Down syndrome (26 males, 27 infants born preterm, 22 infants with congenital heart disease) were videoed at 10–19 weeks post-term (median = 14 weeks). We assessed their Motor Optimality Score (MOS) based on postures and movements (including fidgety movements) and compared it to that of 47 infants later diagnosed with cerebral palsy and 47 infants with a normal neurological outcome, matched for gestational and recording ages.Outcomes and resultsThe MOS (median = 13, range 10–28) was significantly lower than in infants with a normal neurological outcome (median = 26), but higher than in infants later diagnosed with cerebral palsy (median = 6). Fourteen infants with Down syndrome showed normal fidgety movements, 13 no fidgety movements, and 20 exaggerated, too fast or too slow fidgety movements. A lack of movements to the midline and several atypical postures were observed. Neither preterm birth nor congenital heart disease was related to aberrant fidgety movements or reduced MOS.Conclusions and implicationsThe heterogeneity in fidgety movements and MOS add to an understanding of the large variability of the early phenotype of Down syndrome. Studies on the predictive values of the early spontaneous motor repertoire, especially for the cognitive outcome, are warranted.What this paper addsThe significance of this exploratory study lies in its minute description of the motor repertoire of infants with Down syndrome aged 3–5 months. Thirty percent of infants with Down syndrome showed age-specific normal fidgety movements. The rate of abnormal fidgety movements (large amplitude, high/slow speed) or a lack of fidgety movements was exceedingly high. The motor optimality score of infants with Down syndrome was lower than in infants with normal neurological outcome but higher than in infants who were later diagnosed with cerebral palsy. Neither preterm birth nor congenital heart disease were related to the motor performance at 3–5 months.

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“…However, its prevalence was lower than reported in other studies, likely as a result of the high prevalence of young pregnant in the region. Developed countries have shown late pregnancy in women older than 35-years old increases the prevalence of Down syndrome [23].…”

Section: Discussionmentioning

confidence: 99%

Major birth defects in the Brazilian side of the triple border: a population-based cross-sectional study

2020

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Background: Major birth defects increase the risk of fetal death and pediatric hospitalization, which also impact on healthcare costs. Sociodemographic factors can drastically affect reproductive health and be used to discriminate the exposure to hidden risk factors. Foz do Iguassu is a Brazilian city located in the triple-border region of Brazil / Paraguay / Argentina with high rates of birth defects. However no study aimed to verify factors associated with this incidence or preventive care is reported. The current work investigated the prevalence of major birth defects and its association with maternal sociodemographic factors in Foz do Iguassu. Methods: In this population-based cross-sectional study we used data of all live births occurred in Foz do Iguassu from 2012 to 2017. The associated sociodemographic variables such as maternal age, maternal education, maternal race, country of residence, maternal parity and onset of prenatal care were analyzed. Each major birth defect was described according to absolute and relative frequencies, Kruskal-Wallis and logistic regression models were used to evaluate variables associated with selected birth defects. Results: The most prevalent major birth defects were Cleft Lip and/or Palate (9.5/10,000), gastroschisis (6.93/10,000), spina bifida (5.53/10,000), hydrocephalus (5.53/10,000), hypospadias (4.55/10,000), Down syndrome (4.23/10,000), anencephaly (2.93/10,000), anorectal atresia / stenosis (1.95/10,000), undetermined sex (1.95/10,000), esophageal atresia / stenosis with or without fistula (1.63/10,000) and limb reduction defects (1.30/10,000). Maternal age was associated with gastroschisis and Down syndrome. Only maternal education up to 7 years was statistically associated with major birth defects considering all other sociodemographic variables. Conclusion: Cleft Lip and/or Palate and Gastroschisis prevalence were higher than those found in the literature. This findings may suggest a distinct epidemiological behavior regarding major birth defects in the region. The work opens new perspectives for birth defects risk factors in the triple-border.

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Ten-year trends in prevalence of Down syndrome in a developing country: impact of the maternal age and prenatal screening

Cited by 20 publications

References 16 publications

Designed game situations enhance fundamental movement skills in children with Down syndrome

Designed game situations enhance fundamental movement skills in children with Down syndrome

The motor repertoire in 3- to 5-month old infants with Down syndrome

Major birth defects in the Brazilian side of the triple border: a population-based cross-sectional study

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