Ten-Year Trends in the Morbidity of Diabetes Mellitus and Antidiabetic Drug Utilization in Croatia: A Study Based on Routinely Collected Data

Pavlov, Renata; Topličan, Ivančica; Keglević, Mladenka Vrcić

doi:10.1155/2016/9837496

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Pharmaceutical marketing might have had some influence on prescribing the first choice among the SUs, as pointed out by Pavlov in Croatia. 62 This possible influence should be clarified in future research. DPP-4 and GLP-1 were less frequently used but an increase in their use was also observed.…”

Section: Resultsmentioning

confidence: 98%

The characteristics of the outpatient utilisation of medicines in the Republic of Srpska in the period 2009-2017

Marković-Peković¹,

Bojanić²,

Stoisavljević-Šatara³

2019

Scripta Medica

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Background: Monitoring and measuring of the medicine utilisation enables to assess the quality of use of medicines, providing the evidence-based data for the improvement of the prescribing practice and a more rational use of medicines. The aim of this study was to analyse utilisation patterns of medicines and to compare the results with other countries. Methods: A retrospective, observational study to analyse outpatient medicines utilisation in the Republic of Srpska between 2009 and 2017. Data of medicines utilisation were retrieved from the national database in the Public Health Institute of the Republic of Srpska and calculated and analysed by using the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) methodology. The results were expressed as Defined Daily Doses (DDDs) per 1,000 inhabitants per day. Results: Total medicines utilisation increased, from 448 DDDs in 2009 to 1,036 DDDs in 2017. Cardiovascular medicines (group C) were the most used medicines, and their share in the total utilisation increased from 36.6% in 2009 to 44.4% in 2017. Among them, the most frequently used were angiotensin-converting enzyme inhibitors, plain and in combinations with diuretics, namely enalapril. The share of medicines used in diabetes in the total utilisation increased from 3.9% in 2009 to 5.1% in 2017. Metformin and glimepiride accounted for about 83% of the blood glucose lowering medicines group (A10B). Among the antithrombotic medicines, the most frequently used were platelet aggregation inhibitors (B01AC), mainly acetylsalicylic acid whose use tripled since 2009. Diclofenac was the most frequently used non-steroidal anti-inflammatory and antirheumatic drug (M01). Conclusion: The trend of increased medicines utilisation was observed in this study. This finding is comparable with other countries. Variations between countries in the preferred medicines within a class as well as the extent of medicines use were observed. These differences were probably consistent, but not solely attributable, to differences in local guidelines and reimbursement policies.

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Section: Resultsmentioning

confidence: 98%

The characteristics of the outpatient utilisation of medicines in the Republic of Srpska in the period 2009-2017

Marković-Peković¹,

Bojanić²,

Stoisavljević-Šatara³

2019

Scripta Medica

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“…In our study, 8.8% of subjects had T2DM, which is slightly higher than the prevalence in Europe. In 2010, the prevalence of DM in European regions including Russia was 8.5%, and the global prevalence was 6.6% ( 23 ). Hypothyroidism prior to surgery was present in 13.1% of patients, which is significantly higher than the prevalence in the US.…”

Section: Discussionmentioning

confidence: 99%

The Association Between Type 2 Diabetes Mellitus, Hypothyroidism, and Thyroid Cancer

Zubčić

2020

ACC

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SUMMARY This study aimed to investigate the association between type 2 diabetes mellitus (T2DM), antidiabetic therapy, hypothyroidism, and thyroid cancer. We analyzed data from 320 patients who underwent thyroid surgery for suspicion of cancer. The diagnosis of thyroid cancer was confirmed by histopathological analysis in 95 patients. No significant difference was found in the diagnosis of T2DM and hypothyroidism concerning the presence of thyroid cancer (p=0.13; p=0.85), nor in the gender of patients with T2DM and hypothyroidism with respect to the type of thyroid cancer (p=0.19; p=0.25). Patients with T2DM (Odds ratio [OR] 1.89; 95% CI, 0.856-4.163) and patients with hypothyroidism (OR, 1.05; 95% CI, 0.530-2.164) had higher prevalence of thyroid cancer, as did those who had both diagnoses combined (p=0.37; OR, 2.39; 95% CI, 0.333-17.278), compared with the patients who did not have those diagnoses. Men with T2DM (OR, 6.19; 95% CI, 1.180-32.513) had higher prevalence of thyroid cancer than women. Patients who were on oral antidiabetics (OR, 1.91; 95% CI, 0.804-4.512) had higher prevalence of thyroid cancer than those receiving insulin. According to the results of this study, we can conclude that there is an association between T2DM, hypothyroidism, oral antidiabetics, and thyroid cancer.

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A ten-year study of anti-diabetic drugs utilization in Iran

Yousefi

Hemmati

Jaddi

et al. 2022

J Diabetes Metab Disord

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Ten-Year Trends in the Morbidity of Diabetes Mellitus and Antidiabetic Drug Utilization in Croatia: A Study Based on Routinely Collected Data

Cited by 4 publications

References 40 publications

The characteristics of the outpatient utilisation of medicines in the Republic of Srpska in the period 2009-2017

The characteristics of the outpatient utilisation of medicines in the Republic of Srpska in the period 2009-2017

The Association Between Type 2 Diabetes Mellitus, Hypothyroidism, and Thyroid Cancer

A ten-year study of anti-diabetic drugs utilization in Iran

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